Microscopic infrared mapping of chloromethylated polystyrene resin beads

In solid-phase combinatorial chemistry, analyses are performed using a wide range of analytical techniques ranging from gel-phase nuclear magnetic resonance (NMR) to colorimetric tests to elemental analysis. However, these techniques cannot be used to interrogate functional group distribution at the single-bead level. This paper explores the feasibility of using Fourier transform infrared (FTIR) microscopy to examine site distribution on chloromethylated polystyrene resin beads and to quantify the loading after coupling with 4-cyanophenol, an IR tagging agent. FT-IR microscopy also provides a unique opportunity to better understand the reactivity of highly cross-linked polymer beads under a range of chemical conditions

Re-evaluation of the outcome of a multiple component reaction - 2- and 3-amino-imidazo[1,2-a]pyrimidines?

Multi-component reactions between aldehydes, isonitriles and 2-aminoazines do not always give the expected products