All is Well - A diagnostic and management challenge

Ganglioglioma are rare, slow-growing neoplasm with high predilection for temporal lobe. Low-grade gangliogliomas typically curable by surgery and has excellent prognosis. High-grade gangliogliomas managed with total resection and sometimes followed by radiation. The cases reported in literature with edema in the optic chiasm and tract were secondary to sellar/suprasellar tumors, high grade gliomas, aneurysm and had visual dysfunction

Retinal Venule Coverage by Pericytes Decreases in Multiparous Mice in a Time-Dependent Manner Post-Delivery

Structural changes in the retinal vasculature have been linked to increased cardiovascular risks and also change as a function of age. Because multiparity has been associated with poorer cardiovascular health scores, we hypothesized that changes in retinal vascular caliber would be observed in multiparous, compared to nulliparous, females and retired breeder males. Age-matched nulliparous (n = 6) and multiparous (n = 11, retired breeder females with 4 ± 1 litters), and male breeder (n = 7) SMA-GFP reporter mice were included for assessment of retinal vascular structure. Multiparous females had higher body mass, heart weight, and kidney weight compared to nulliparous mice, with lower kidney and higher brain weight compared to male breeders. There was no difference in number of retinal arterioles or venules, or arteriole or venule diameter among groups; however, venous pericyte density (number per venule area) decreased in multiparous vs. nulliparous mice and was negatively associated with the time since last litter and with age. Our results suggest that the time elapsed since delivery is an important factor to be considered in multiparity studies. Taken together, changes in vascular structure and potentially function, are time- and age-dependent. Ongoing and future work will determine whether structural changes are associated with functional consequences at the blood–retinal barrier

Erdheim-Chester Disease Presenting with Diplopia; A Challenging Diagnosis and Effective Treatment

Erdheim-Chester Disease (ECD) is an infiltrative disease which can involve the CNS and presents with different symptoms. Herein, we present a patient with ECD who presented with sixth nerve palsy, with a challenging course of diagnosis and successful treatment with two specific protein-targeting agents