Design and Implementation of Modified Zeta Converter for Solar Water Pumping Application

The linear increase in the growth of the population demands a requisite for energy resources. Knowing the loathsome truth that non-renewable sources will ultimately exhaust, the significance of renewable sources cannot be undervalued. Considering various factors, many work areas are reliant upon fossil fuels for the generation of electricity. The use of fossil fuels will increase the quality of power production but will drain one day, and industries must change to renewable sources. The earliest system that strikes a chord with regard to renewable energy is the photovoltaic (PV) energy system. In this specific circumstance, interest in solar systems is expanding step by step, and its installations are becoming broad. The implementation of the solar water pumping method used for irrigation purposes using a Zeta converter was best suited for small and minor farmers, but still, the efficiency of the system can be upgraded with the use of filters. The vantage of the ZETA converter has less result voltage ripple and smooth water pumping application. The PV-based system has reached the point where it is used in Electric vehicles by enhancing the standard operating condition of the converter under the steady and dynamic behavior of a PV system. Eventually, it can be worked considerably under minimum solar irradiance. Maximum power point tracking (MPPT) of the signal had dominant performance in a zeta converter circuit while sign levels ripple current, and voltage on the output side was compact

Pairwise comparison of hydrochlorothiazide and chlorthalidone responses among hypertensive patients

Abstract This study conducted a pairwise comparison of antihypertensive and metabolic effects of hydrochlorothiazide (HCTZ) and chlorthalidone (CTD) at 25 mg/day in the same individuals to address the clinical dilemma on preferred thiazide for hypertension (HTN) management. We included 15 African American (AA) and 35 European American (EA) patients with HTN treated with HCTZ and CTD as part of the Pharmacogenomic Evaluation of Antihypertensive Responses (PEAR) and PEAR‐2 trials, respectively. Mean reduction in systolic/diastolic blood pressure (SBP/DBP) with HCTZ versus CTD was 8/5 versus 16/8 mmHg among EA patients (p < 1.0e−5 SBP, p = 0.002 DBP) and 11/8 versus 20/11 mmHg among AA patients (p = 0.03 SBP, p = 0.22 DBP). While CTD showed clinically meaningful benefit over HCTZ in two‐thirds of participants with respect to SBP reduction and half of EA patients with respect to DBP reduction, a majority of AA patients (53%) showed similar DBP reduction with both thiazides. Sixty percent of AA patients and 29% of EA patients attained blood pressure (BP) <140/90 mmHg with both thiazides. Mean potassium (K+) reduction was greater with CTD compared to HCTZ both in EA patients (mean difference = 0.35, p = 0.0002) and AA patients (0.49, p = 0.043). While 31% of AA patients developed severe hypokalemia on CTD, <5% of others developed severe hypokalemia. Although 46% of AA patients on CTD required K+ supplementation, only 6%–11% of others required supplementation. Overall, in the majority of EA patients, CTD was superior to HCTZ, whereas among AA patients, it was superior in a minority, and was associated with significant potassium‐related risk, suggesting that guideline preferences for CTD over HCTZ are reasonable in EA patients but may be less reasonable in AA patients, particularly if the target is <140/90 mmHg

Circulating microRNA Biomarkers of Thiazide Response in Hypertension

Background: Thiazide diuretics are the second most frequently prescribed class of antihypertensives, but up to 50% of patients with hypertension have minimal antihypertensive response to thiazides. We explored circulating microRNAs (miRNAs) in search of predictive biomarkers of thiazide response. Methods and results: We profiled 754 miRNAs in baseline plasma samples of 36 hypertensive European American adults treated with hydrochlorothiazide, categorized into responders (n=18) and nonresponders (n=18) on the basis of diastolic blood pressure response to hydrochlorothiazide. miRNAs with ≥2.5-fold differential expression between responders and nonresponders were considered for validation in 3 cohorts (n=50 each): hydrochlorothiazide-treated European Americans, chlorthalidone-treated European Americans, and hydrochlorothiazide-treated Black individuals. Different blood pressure phenotypes including categorical (responder versus nonresponder) and continuous diastolic blood pressure and systolic blood pressure were tested for association with the candidate miRNA expression using multivariate regression analyses adjusting for age, sex, and baseline blood pressure. After quality control, 74 miRNAs were available for screening, 19 of which were considered for validation. In the validation cohort, miR-193b-3p and 30d-5p showed significant associations with continuous SBP or diastolic blood pressure response or both, to hydrochlorothiazide in European Americans at Benjamini-Hochberg adjusted P Conclusions: The above identified circulating miRNAs may have a potential for clinical use as biomarkers for thiazide diuretic selection in hypertension. URL: ClinicalTrials.gov. Unique identifiers: NCT00246519, NCT01203852, NCT00005520.</p

The effect of ceria and zirconia nanoparticles on the corrosion behaviour of cataphoretic epoxy coatings on AA6060 alloy

In this work an attempt was made to produce epoxy coating doped with ceria (CeO2) and/or zirconia (ZrO2) nanoparticles, in single step electrophoretric deposition process. Deposition was carried out on AA6060 cataforetically from epoxy resin suspension containing synthesized stable aqueous colloidal dispersions (sols) of CeO2 and ZrO2. The influence of ceria and zirconia nanoparticles on the physicochemical characteristics of epoxy coatings was evaluated by energy dispersive X-ray fluorescence spectroscopy, X-ray photoelectron spectroscopy, field-emission scanning electron microscopy, Fourier-transform infrared spectroscopy, thermogravimetric analysis and adhesion measurements, while their corrosion stability during immersion in 0.5 M NaCl solution was monitored by electrochemical impedance spectroscopy. All ceria and/or zirconia containing coatings showed better corrosion stability and adhesion than pure epoxy coating, while between doped epoxy coatings one with CeO2/ZrO2 exhhibited the greatest values of charge-transfer resistance due to synergetic effect of both types of added nanoparticles