Two-Photon Absorption Light-Induced Self-Written Waveguide for Single-Mode Optical Interconnection

International audienceWe propose two-photon absorption light-induced self-written (LISW) waveguide formation using short-wavelength infrared pulse laser light. It is suitable and efficient for single-mode optical interconnection, and also promising for small-core single-mode optical interconnection. The approach offers the possibility of not only decreasing the insertion loss, but also reducing the interconnection task time. We assessed this approach for single-mode optical interconnection. We obtained an LISW waveguide loss of about 0.06 dB for an LISW waveguide length of 100 μm and a connection loss per facet of about 0.37 dB. We also presented the results on the interconnection between high-numerical-aperture small-core thermally-diffused expanded-core single-mode fibers having the mode field diameters of about 3 μm by using the same approach. The results showed the present approach to be a promising alternative route for efficient interconnection of small-core single-mode optical devices, such as silicon nanowires with appropriate configurations

Light-induced self-written waveguide fabrication using 1550 nm laser light

International audienceLight-induced self-written (LISW) optical waveguides were fabricated for the first time, to the best of our knowledge, using a photopolymerizable resin system formed by 1550 nm pulse laser light. A two-photon absorption (TPA) chromophore with a TPA cross section of several hundred Goeppert-Mayer (GM) at 1550 nm was used. Furthermore, the optical interconnection between a single-mode fiber and a fiber Bragg grating was demonstrated by the present technique, using one-way irradiation of 1550 nm laser light through the single-mode fiber. The LISW waveguide formation using 1550 nm laser light offers a new and promising alternative route for optical interconnection in silicon photonics technology

Treatment of Non-Small-Cell Lung Cancer with Erlotinib following Gefitinib-Induced Hepatotoxicity: Review of 8 Clinical Cases

Objective. Gefitinib often induces liver damage. A few reports have described that the subsequent administration of erlotinib was associated with less hepatotoxicity, but the safety and efficacy of this treatment are still not fully investigated. Therefore, we evaluated retrospectively the patients with erlotinib following gefitinib-induced hepatotoxicity. Methods and Patients. We retrospectively reviewed the medical records between December 2007 and March 2010. The patients were evaluated including the following information: age, gender, histology of lung cancer, performance status, smoking status, epidermal growth factor receptor (EGFR) mutation status, liver metastasis, viral hepatitis, alcoholic liver injury, clinical response, and hepatotoxicity due to EGFR tyrosine kinase inhibitors. Results. We identified 8 patients with erlotinib following gefitinib-induced hepatotoxicity. All achieved disease control by gefitinib. Hepatotoxicity was grades 2 and 3 in 3 and 5 patients, respectively. The median duration of treatment with gefitinib was 112.5 days and the median time to gefitinib-induced hepatotoxicity was 51.5 days. The median duration of treatment with erlotinib was 171.5 days. Grade 1 and 2 erlotinib-induced hepatotoxicity was observed in 2 and 1 patient, respectively. Conclusions. Erlotinib administration with careful monitoring is thought to be a good alternative strategy for patients who respond well to gefitinib treatment but experience hepatotoxicity