Management Options that Increase Herbage Production in Grassland-Based Livestock Production Systems

Herbage production is the most important measure of performance of grassland systems. Understanding how herbage production responds to various managements is crucial to the success of grassland systems, whether or not maximization of production is pursued. Most of the records of grassland production in the literature are taken as acceptable approximations of net herbage production. Analysis of these production records and accompanying quality data can generalize the response of grassland productivity and quality to individual managements, and can characterize the managements in terms of their efficiency and potential in increasing productivity and quality. Overall, maximum production response is ranked irrigation (11.2 t DM/ha) \u3e nitrogen (N) fertilizer (9.8 t DM/ha) \u3e legume mixture (5.2 t DM/ha) \u3e phosphorus fertilizer (3.4 t DM/ha) \u3e cutting frequency (2.5 t DM/ha) ≈ potassium fertilizer (2.4 t DM/ha) \u3e cutting intensity (1.9 t DM/ha). Maximum response of herbage N concentration is greatest for N fertilizer (16 g/kg DM, for grasses) followed by legume mixture (14 g/kg DM), cutting frequency (8 g/kg DM) and cutting intensity (2 g/kg DM). Management of grassland systems for achieving a specified production and/or quality goal needs to consider different patterns of production and quality response to individual management inputs as well as other conditions (e.g. plant species, site conditions) involved in the systems

Cholecystokinin receptor antagonist, loxiglumide, inhibits invasiveness of human pancreatic cancer cell lines

AbstractRecently, cholecystokinin has been reported to be important in regulating the growth of pancreatic cancer. We investigated the effect of loxiglumide (LXG), a cholecytskinin receptor antagonist, on the invasiveness of two human pancreatic cancer cell lines. Cells were treated with LXG for 24 h, and examined in the invasion assay. The expression and activity of MMP-9 in supernatants from cancer cells were analyzed by Western blotting and zymogram. Interestingly, the invasiveness of cancer cells and expression of MMP-9 were decreased by LXG in a dose-dependent manner. LXG may be a useful therapeutic agent against pancreatic cancer

ヤマダ デンキ ト ヨドバシカメラ ノ センリャク ヒカク : カデン リョウハンテン ノ サバイバル センリャク

現在、家電量販業界では、熾烈な戦いが繰り広げられている。本稿ではその中でマーケットリーダーのヤマダ電機と人材教育に定評があるヨドバシカメラを採りあげる。ヤマダ電機とヨドバシカメラの戦略はマイケル・E・ポーターの3 つの基本戦略に照らし合せると、現在のところ、それぞれコストリーダーシップ戦略、差別化戦略を採って成功している。本論文では、両社のそれぞれの戦略について詳述し、さらに今後の激変する環境の中で両社が採っている戦略をどのような変化させていくのかを検討する。Recently there is a cutthroat battle among electronic stores in Japan. In this paper, we will look at two companies. One is Yamada Denki, the market leader in the industry, and the other is Yodobashi Camera, the leader in terms of Human Resources Management(HRM). We argue that Yamada Denki\u27s success is due to their implementation of the Cost Leadership Strategy as stated in Michael E. Porter\u27s three generic strategies while on the other hand, Yodobashi Camera has achieved positive results using Porter\u27s Differentiation Strategy. In this paper, We discuss each of the two strategies as utilized by Yamada and Yodobashi

On the origin and evolution of the asteroid Ryugu: A comprehensive geochemical perspective

Presented here are the observations and interpretations from a comprehensive analysis of 16 representative particles returned from the C-type asteroid Ryugu by the Hayabusa2 mission. On average Ryugu particles consist of 50% phyllosilicate matrix, 41% porosity and 9% minor phases, including organic matter. The abundances of 70 elements from the particles are in close agreement with those of CI chondrites. Bulk Ryugu particles show higher δ18O, Δ17O, and ε54Cr values than CI chondrites. As such, Ryugu sampled the most primitive and least-thermally processed protosolar nebula reservoirs. Such a finding is consistent with multi-scale H-C-N isotopic compositions that are compatible with an origin for Ryugu organic matter within both the protosolar nebula and the interstellar medium. The analytical data obtained here, suggests that complex soluble organic matter formed during aqueous alteration on the Ryugu progenitor planetesimal (several 10’s of km), <2.6 Myr after CAI formation. Subsequently, the Ryugu progenitor planetesimal was fragmented and evolved into the current asteroid Ryugu through sublimation

Tokyo Guidelines 2018: initial management of acute biliary infection and flowchart for acute cholangitis

The initial management of patients with suspected acute biliary infection starts with the measurement of vital signs to assess whether or not the situation is urgent. If the case is judged to be urgent, initial medical treatment should be started immediately including respiratory/circulatory management if required, without waiting for a definitive diagnosis. The patient's medical history is then taken; an abdominal examination is performed; blood tests, urinalysis, and diagnostic imaging are carried out; and a diagnosis is made using the diagnostic criteria for cholangitis/cholecystitis. Once the diagnosis has been confirmed, initial medical treatment should be started immediately, severity should be assessed according to the severity grading criteria for acute cholangitis/cholecystitis, and the patient's general status should be evaluated. For mild acute cholangitis, in most cases initial treatment including antibiotics is sufficient, and most patients do not require biliary drainage. However, biliary drainage should be considered if a patient does not respond to initial treatment. For moderate acute cholangitis, early endoscopic or percutaneous transhepatic biliary drainage is indicated. If the underlying etiology requires treatment, this should be provided after the patient's general condition has improved; endoscopic sphincterotomy and subsequent choledocholithotomy may be performed together with biliary drainage. For severe acute cholangitis, appropriate respiratory/circulatory management is required. Biliary drainage should be performed as soon as possible after the patient's general condition has been improved by initial treatment and respiratory/circulatory management. Free full articles and mobile app of TG18 are available at: http://www.jshbps.jp/modules/en/index.php?content_id=47 . Related clinical questions and references are also include

A pristine record of outer Solar System materials from asteroid Ryugu’s returned sample

Volatile and organic-rich C-type asteroids may have been one of the main sources of Earth’s water. Our best insight into their chemistry is currently provided by carbonaceous chondritic meteorites, but the meteorite record is biased: only the strongest types survive atmospheric entry and are then modified by interaction with the terrestrial environment. Here we present the results of a detailed bulk and microanalytical study of pristine Ryugu particles, brought to Earth by the Hayabusa2 spacecraft. Ryugu particles display a close compositional match with the chemically unfractionated, but aqueously altered, CI (Ivuna-type) chondrites, which are widely used as a proxy for the bulk Solar System composition. The sample shows an intricate spatial relationship between aliphatic-rich organics and phyllosilicates and indicates maximum temperatures of ~30 °C during aqueous alteration. We find that heavy hydrogen and nitrogen abundances are consistent with an outer Solar System origin. Ryugu particles are the most uncontaminated and unfractionated extraterrestrial materials studied so far, and provide the best available match to the bulk Solar System composition

Delphi consensus on bile duct injuries during laparoscopic cholecystectomy:An evolutionary cul-de-sac or the birth pangs of a new technical framework?

Bile duct injury (BDI) during laparoscopic cholecystectomy remains a serious iatrogenic surgical complication. BDI most often occurs as a result of misidentification of the anatomy; however, clinical evidence on its precise mechanism and surgeons' perceptions is scarce. Surgeons from Japan, Korea, Taiwan, and the USA, etc. (n=614) participated in a questionnaire regarding their BDI experience and near-misses; and perceptions on landmarks, intraoperative findings, and surgical techniques. Respondents voted for a Delphi process and graded each item on a five-point scale. The consensus was built when 80% of overall responses were 4 or 5. Response rates for the first- and second-round Delphi were 60.6% and 74.9%, respectively. Misidentification of local anatomy accounted for 76.2% of BDI. Final consensus was reached on: (1) Effective retraction of the gallbladder, (2) Always obtaining critical view of safety, and (3) Avoiding excessive use of electrocautery/clipping as vital procedures; and (4) Calot's triangle area and (5) Critical view of safety as important landmarks. For (6) Impacted gallstone and (7) Severe fibrosis/scarring in Calot's triangle, bail-out procedures may be indicated. A consensus was reached among expert surgeons on relevant landmarks and intraoperative findings and appropriate surgical techniques to avoid BD