53 research outputs found
Decreased protein-synthetic activity is an early consequence of spermidine depletion in rat hepatoma tissue-culture cells
Full text linkPost-translational modification of the protein-synthesis initiation factor eIF-4D by spermidine in rat hepatoma cells
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Polyamines and cancer: old molecules, new understanding
Full text linkThe amino-acid-derived polyamines have long been associated with cell growth and cancer, and specific oncogenes and tumour-suppressor genes regulate polyamine metabolism. Inhibition of polyamine synthesis has proven to be generally ineffective as an anticancer strategy in clinical trials, but it is a potent cancer chemoprevention strategy in preclinical studies. Clinical trials, with well-defined goals, are now underway to evaluate the chemopreventive efficacy of inhibitors of polyamine synthesis in a range of tissues
Alpha-methyl ornithine, a potent competitive inhibitor of ornithine decarboxylase, blocks proliferation of rat hepatoma cells in culture
Full text linkRestoration of the polyamine contents in rat hepatoma tissue-culture cells after inhibition of polyamine biosynthesis. Relationship with cell proliferation
Full text linkEffects of (2R, 5R)-6-heptyne-2,5-diamine, a potent inhibitor of l-ornithine decarboxylase, on rat hepatoma cells cultured in vitro
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