89 research outputs found
Cysteine Redox Potential Determines Pro-Inflammatory IL-1β Levels
Cysteine (Cys) and its disulfide, cystine (CySS) represent the major extracellular thiol/disulfide redox control system. The redox potential (E(h)) of Cys/CySS is centered at approximately -80 mV in the plasma of healthy adults, and oxidation of E(h) Cys/CySS is implicated in inflammation associated with various diseases.The purpose of the present study was to determine whether oxidized E(h) Cys/CySS is a determinant of interleukin (IL)-1beta levels. Results showed a 1.7-fold increase in secreted pro-IL-1beta levels in U937 monocytes exposed to oxidized E(h) Cys/CySS (-46 mV), compared to controls exposed to a physiological E(h) of -80 mV (P<0.01). In LPS-challenged mice, preservation of plasma E(h) Cys/CySS from oxidation by dietary sulfur amino acid (SAA) supplementation, was associated with a 1.6-fold decrease in plasma IL-1beta compared to control mice fed an isonitrogenous SAA-adequate diet (P<0.01). Analysis of E(h) Cys/CySS and IL-1beta in human plasma revealed a significant positive association between oxidized E(h) Cys/CySS and IL-1beta after controlling for age, gender, and BMI (P<0.001).These data show that oxidized extracellular E(h) Cys/CySS is a determinant of IL-1beta levels, and suggest that strategies to preserve E(h) Cys/CySS may represent a means to control IL-1beta in inflammatory disease states
Níveis de metionina + cistina para leitões dos 6 aos 16 kg submetidos a diferentes graus de ativação do sistema imune
Métabolisme des acides aminés soufrés au cours du sepsis
*INRA, Centre de Recherches de Clermont-Ferrand/Theix. Laboratoire de Recherches sur l'Etude du Métabolisme Azoté, Unité Sepsis, Theix, 63122 St Genès Champanelle (FRA) Diffusion du document : INRA, Centre de Recherches de Clermont-Ferrand/Theix. Laboratoire de Recherches sur l'Etude du Métabolisme Azoté, Unité Sepsis, Theix, 63122 St Genès Champanelle (FRA) Diplôme : Dr. d'Universit
Coordinated response of liver and muscle protein synthesis to fasting and refeeding in 12-month-old rats
Hypoalbuminémie (un bon outil de dépistage des patients à risque de dénutrition et de mortalité hospitalière)
CAEN-BU Médecine pharmacie (141182102) / SudocSudocFranceF
Gas chromatographic-mass spectrometric analysis of stable isotopes of cysteine and glutathione in biological samples
International audienc
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