Procjena rizika izloženosti prema epidemiološkom registru

Population registration in Sweden dates back to 1749. The personal identification number, unique for each individual, was introduced in the late 1940s. This number facilitates the linkage, at the individual level, of information from effect registers (e.g. the Cause of Death Registry or the Cancer Registry) and registers containing information on possible exposures or on occupation and industry. A linkage between an effect register and a census can be used to screen for high risk groups in different work environments. This usage is exemplified with studies on malignant pleural mesotheliomas and nasal cancer. The results were in agreement with previous knowledge about risk environments but also yielded some new hypotheses. Some problems in register epidemiology are reviewed. Comments are made on the use and usefulness of register epidemiology and also on possible study designs for the follow-up of the hypotheses arising from such studies.Registri u Švedskoj postoje od 1749. godine. Potkraj četrdesetih godina ovog stoljeća uveden je osobni identifikacijski broj jedinstven za svaku osobu, koji olakšava povezivanje podataka iz različitih registara. Tako se mogu povezati podaci za pojedinca iz npr. Registra uzroka smrti i Registra malignih bolesti s registrima koji sadrže podatke o mogućoj izloženosti ili vrstama zaposlenja. Ovakvim povezivanjem mogu se dobiti podaci o visokorizičnim skupinama u različitim radnim okolinama. Izneseni su primjeri povezivanja malignog pleuralnog mezotelioma i raka nosa. Rezultati se slažu s dosadašnjim saznanjima o mogućim okolinskim faktorima nastanka ovih bolesti, no iznose se i neke nove pretpostavke. Pregledno su prikazani neki problemi vezani uz epidemiološke registre. Iznesene su neke upute o mogućnosti upotrebe i korisnosti ovakvih registara, kao i o planiranju prospektivnih studija temeljenih na dobivenim pretpostavkama

Risk of urinary bladder cancer: a case-control analysis of industry and occupation

<p>Abstract</p> <p>Background</p> <p>Uncertainty remains about urinary bladder cancer (UBC) risk for many occupations. Here, we investigate the association between occupation, industry and UBC.</p> <p>Methods</p> <p>Lifetime occupational history was collected by in-person interview for 604 newly diagnosed UBC patients and 604 cancer-free controls. Each job title was assigned a two-digit industry code and a three-digit occupation code. Odds ratios (ORs) for UBC associated with ever being employed in an industry or occupation were calculated by unconditional logistic regression adjusting for age, gender and smoking status. We also examined UBC risk by duration of employment (>0 to <10, ≥10 years) in industry or occupation.</p> <p>Results</p> <p>Significantly increased risk of UBC was observed among waiters and bartenders (OR 2.87; 95% CI 1.05 to 7.72) and occupations related to medicine and health (OR 2.17; 95% CI 1.21 to 3.92), agricultural production, livestock and animal specialties (OR 1.90; 95% CI 1.03 to 3.49), electrical assembly, installation and repair (OR 1.69; 95% CI 1.07 to 2.65), communications (OR 1.74; 95% CI 1.00 to 3.01), and health services (OR 1.58; 95% CI 1.02 to 2.44). For these occupations we also observed a significant excess risk of UBC for long-term work (i.e. ≥10 years), with the exception of waiters and bartenders. Employment for 10 years or more was associated with increased risk of UBC in general farmers (OR 9.58; 95% CI 2.18 to 42.05), agricultural production of crops (OR 3.36; 95% CI 1.10 to 10.27), occupations related to bench working (OR 4.76; 95% CI 1.74 to 13.01), agricultural, fishery, forestry & related (OR 4.58; 95% CI 1.97 to 10.65), transportation equipment (OR 2.68; 95% CI 1.03 to 6.97), and structural work (OR 1.85; 95% CI 1.16 to 2.95).</p> <p>Conclusions</p> <p>This study provides evidence of increased risk of UBC for occupations that were previously reported as at-risk. Workers in several occupation and industry groups have a significantly higher risk of UBC, particularly when duration of employment is 10 years or more.</p