Standred interferon therapy and its Response rates in Chronic HCV Patients in District Mardan, Khyber Pakhtunkhwa

To eradicate the Hepatitis C Virus from the bodies of the infected individuals Interferon and Ribavirin based therapy is used. HCV is highly prevalent in District Mardan Khyber Pakhtunkhwa that is why it is important to determine the response of standard interferon based therapy in Chronic HCV patients of this region. A total of 215 patients were selected for interferon based therapy. The patients were selected from three different Tehsil of District Mardan. After confirmation of active HCV infection by q-PCR, standard interferon with Ribavirin was given to patients for 6 months. After completion of therapy, end of treatment virologic response (ETR) was calculated. After completion of the 6 months long therapy, the results obtained were as. Out of total 215 patients, 168 (78.13%) were negative for HCV RNA and showing end of treatment response (ETR) while 47 (21.86%) were positive for HCV RNA and did not show ETR. In Tehsil Mardan, out of 102 patients who had completed therapy, 76 patients (74.51%) showed ETR and 26 (25.49%) did not show the ETR. In Tehsil Kattlang, we found that out of total 51 patients who had taken 6 months therapy, 41 (80.39%) were negative for HCV RNA and 10 (19.61%) were resistant to therapy while in Tehsil Tkhatbhai, out of 62, 50 (80.64%) were negative and 12 (19.35%) were positive. The above discussion shows that antiviral therapy against HCV infection in chronic HCV patients of District Mardan KPK province is 78.13%. The high response rate may be due to the prevalence of genotypes 2 and 3