Stereological study of the effect of noise stress on the fetus mouse kidney

Background: Sound pollution causes kidney damage in adult but this effect of sound exposure on the fetus is unknown. Therefore, the aim of this study was to find the effect of noise on the structure and volume of fetal kidney. Materials & methods: A total of 32 pregnant mice were divided into four groups. Pregnant mouse in experimental groups were exposed to load 100 dB continuous noise stress, 2.5 hour per day. After birth, fetus kidneys were removed at days 7 and 14. Tissues processing were performed, and sections with 0.5 micron thickness were prepared with orientator method. Total volume and volume of cortex and medulla were calculated according to Cavalier principle. Amount of matrix, inflammatory reaction and necrosis were evaluated by Knodell Scoring system. Results: The results show that there was no significant difference between the volume of different parts of kidney in experimental and control groups (P<0.05). Microscopic evaluations also revealed that sound wave has no effect on the histological structure of kidney. Conclusion: It seems that sound wave has no effect on structure and volume of kidney