Epigenetics: Pharmacology and Modification Mechanisms Involved in Cardiac, Hepatic and Renal Disease

For a long time scientists have tried to describe disorders are due to genetic as well as environmental factors. In the past few years, revolution in technology that has made it possible to decipher the human genome. Epigenetics explains the capability gene expression regulation without modifying the genetic sequence. Epigenetic mechanisms are rooted changes in molecules, or nuclear characteristics that can alter gene expression without altering the sequences of DNA, i.e. DNA methylation, histone modification, and non-coding RNAs. Learning of the fundamental epigenetic modification allowing gene expression as well as cellular phenotype are advanced that novel insights into the epigenetic control of cardiovascular disease, hepatic disease, as well as chronic kidney disease are now emerging. From a half of century ago, in human disease the role of epigenetics has been considered. This subject has attracted many interests in the past decade, especially in complicated diseases like cardiovascular disease, hepatic disease as well as chronic kidney disease. This review first illustrates the history and classification of epigenetic modifications and the factors (i.e. genetic, environment, dietary, thought process and lifestyle) affecting to the epigenetics mechanisms. Likewise, the epigenetics role in human diseases is think out by targeting on some diseases and at the end, we have given the future perspective of this field. This review article provides concepts with some examples to describe a broad view of distinct aspects of epigenetics in biology and human diseases. Keywords: - Epigenetics, DNA methylation, Histone modifications, microRNAs and Gene expression and Disease

Pemetaan Daerah Rawan Erosi dengan Menggunakan Aplikasi Penginderaan Jauh dan Sistem Informasi Geografi di Kabupaten Timor Tengah Selatan Propinsi Nusa Tenggara Timur

Telah dilakukan pemetaan daerah rawan erosi di Kabupaten Timor Tengah Selatan Provinsi Nusa Tenggara Timur dengan menggunakan aplikasi penginderaan jauh dan sistem infomasi geografi. Tujuan dari penelitian ini adalah  untuk memetakan daerah rawan erosi dan tingkat kerawanannya di Kabupaten Timor Tengah selatan, Propinsi Nusa Tenggara Timur. Metode penelitian berupa pembuatan peta curah hujan, pembuatan peta tutupan lahan, dan pembuatan peta kelas lereng. Berdasarkan dari hasil penelitian, tingkat rawan erosi dibagi menjadi tiga kelas yaitu: kelas tidak rawan erosi  dengan luas wilayah 127.218,69 Ha meliputi kecamatan Noebeba, kecamatan Amanuban Selatan, kecamatan Kualin, sebagian kecamatan Amanuban Timur dan kecamatan Fatukopa. Kelas  rawan erosi  dengan luas wilayah 251.082,09 Ha meliputi hampir seluruh kecamatan Timor Tengah Selatan dan kelas sangat rawan erosi sekitar 9.125,1 Ha meliputi wilayah kecamatan Fatumnasi, kecamatan Tobu, kecamatan Mollo Utara, sebagian kecamatan Kot'olin. Kata kunci: Peta Rawan Erosi, Penginderaan Jauh, Sistem Informasi Geografi. &nbsp

EFFECT OF LOWER ETHANOL GASOLINE BLENDS ON PERFORMANCE AND EMISSION CHARACTERISTICS OF THE SINGLE CYLINDER SI ENGINE

Alcohols, basically ethanol is considered as a leading alternative fuel for automotive application because of its ability to reduce the air pollution and cost of the fuel. This paper investigates the effect of lower ethanol gasoline blends (up to 20% by volume) on performance and emission characteristics of the single cylinder four stroke SI engine. Tests were carried out for power, torque, fuel consumption and brake mean effective pressure, while exhaust emissions were analyzed for CO, CO2, and HC by using different ethanol gasoline blends on volume basis at wide open throttle and variable engine speed from 4000 to 8000 rpm. Results were compared with the pure gasoline. It showed that as the ethanol content increases the power, torque, fuel consumption, brake mean effective pressure and CO2 emission while reduces HC and CO emission

Ceramic synthesis of disordered lithium rich oxyfluoride materials

Disordered lithium-rich transition metal oxyfluorides with a general formula Li$_{1+x}$MO$_{2}$F$_{x}$ (M being a transition metal) are gaining more attention due to their high specific capacity which can be delivered from the facecentered cubic (fcc) structure. The most common synthesis procedure involves use of mechanosynthesis. In this work, ceramic synthesis of lithium rich iron oxyfluoride and lithium rich titanium oxyfluoride are reported. Two ceramic synthesis routes are developed each leading to the different level of doping with Li and F and different levels of cationic disorder in the structure. Three different Li$_{1+x}$MO$_{2}$F$_{x}$ samples (x ¼ 0.25, 0.3 and 1) are compared with a sample prepared by mechanochemical synthesis and non-doped LiFeO2 with fcc structure. The obtained lithium rich iron oxyfluoride are characterized by use of M€ossbauer spectroscopy, X-ray absorption spectroscopy, NMR and TEM. Successful incorporation of Li and F have been confirmed and specific capacity that can be obtained from the samples is in the correlation with the level of disorder introduced with doping, nevertheless oxidation state of iron in all samples is very similar. Conclusions obtained from lithium rich iron oxyfluoride are validated by lithium rich titanium oxyfluoride

Experimental evidence for fast cluster formation of chain oxygen vacancies in YBa2Cu3O7-d being at the origin of the fishtail anomaly

We report on three different and complementary measurements, namely magnetisation measurements, positron annihilation spectroscopy and NMR measurements, which give evidence that the formation of oxygen vacancy clusters is on the origin of the fishtail anomaly in YBa2Cu3O7-d. While in the case of YBa2Cu3O7.0 the anomaly is intrinsically absent, it can be suppressed in the optimally doped state where vacancies are present. We therefore conclude that the single vacancies or point defects can not be responsible for this anomaly but that clusters of oxygen vacancies are on its origin.Comment: 10 pages, 4 figures, submitted to PR

Eumelanin Graphene-Like Integration: The Impact on Physical Properties and Electrical Conductivity

The recent development of eumelanin pigment-based blends integrating "classical" organic conducting materials is expanding the scope of eumelanin in bioelectronics. Beyond the achievement of high conductivity level, another major goal lays in the knowledge and feasible control of structure/properties relationship. We systematically investigated different hybrid materials prepared by in situ polymerization of the eumelanin precursor 5,6-dihydroxyindole (DHI) in presence of various amounts of graphene-like layers. Spectroscopic studies performed by solid state nuclear magnetic resonance (ss-NMR), x-ray photoemission, and absorption spectroscopies gave a strong indication of the direct impact that the integration of graphene-like layers into the nascent polymerized DHI-based eumelanin has on the structural organization of the pigment itself, while infrared, and photoemission spectroscopies indicated the occurrence of negligible changes as concerns the chemical units. A tighter packing of the constituent units could represent a strong factor responsible for the observed improved electrical conductivity of the hybrid materials, and could be possible exploited as a tool for electrical conductivity tuning