Behemoth latinus: Adam Ebert, tacitizem in Hobbes

This article investigates the history and significance of the Latin translation of Hobbes's Behemoth which was prepared in 1708 by Adam Ebert (b. 1653-7; d. 1735) and deposited by him in the King of Prussia's library. Ebert's special interest in Hobbes was based partly on having met him in London in 1678; but it also grew out of his wider interest in 'reason of state' and a Tacitist theory of political action. Such wider interests led also to a fascination with Cromwell, and Ebert even tried to present Behemoth as a celebration of Cromwell's political skills. This article considers Ebert as a late representative of the Tacitist tradition, and argues that although Ebert's reading of Hobbes was responding to some elements genuinely present in Hobbes's political thought, Hobbes nevertheless went beyond Tacitism to reach a very different view of politics and government.Članek preučuje zgodovino in pomen latinskega prevoda Hobbesovega Behemotha, ki gaje leta 1708 pripravil Adam Ebert (1653-1735) in shranil v knjižnici pruskega kralja. Ebertaje Hobbes posebno zanimal deloma zato, ker gaje leta 1678 srečal v Londonu, vendar tudi zato, ker je veliko razmišljal o "raggione di stato" in tacitovski teoriji političnega delovanja. Ti njegovi širši interesi so spodbudili tudi občudovanje Cromwella, tako daje Ebert celo hotel prikazati Behemoth kot slavljenje Cromwellovih političnih veščin. Avtor obravnava Eberta kot poznega predstavnika tacitistične tradicije in argumentira, daje Hobbes - četudi je Ebertovo branje Hobbesa bilo v sozvočju z nekaterimi elementi, ki so v Hobbesovi politični misli resnično prisotni - presegel tacitizem in formuliral zelo drugačen pogled na politiko in oblast

DEFECTS IN HEMATOPOIETIC DIFFERENTIATION IN NZB AND NZC MICE

Hematopoietic stem cell activity in inbred NZB and NZC mice has been determined by transplantation and endogenous spleen colony assays. Whereas NZB mice show normal colony-forming unit (CFU) activity in the transplantation assay, they show markedly elevated endogenous CFU. NZC mice also show this markedly elevated endogenous CFU activity, but in the transplantation assay show only about 5–10% of normal CFU counts. When NZC stem cells are tested for CFU activity in irradiated recipients of the H-2d type, almost normal colony numbers occur. NZB stem cells however also cannot form colonies in NZC mice. These results suggest that NZC mice have a defect in the micro-environment of the spleen which renders them incapable of allowing transplanted CFU to form colonies. Genetic analysis of both the NZC defect as a CFU recipient, and the elevated endogenous count in NZB and NZC, shows that both are controlled by single recessive genes which are not linked to either coat color, agouti, H-2 or Ig loci. Of even more relevance is the finding that these hematopoietic abnormalities are not linked to the genes involved in controlling autoantibody formation to red cells in the NZB mice. These mice therefore appear to show two distinct hematopoietic abnormalities, the analysis of which may be of considerable value in understanding the detailed events of hematopoietic stem cell differentiation

Communication : the correspondence of Thomas Hobbes : some new items

Peer reviewe

Mapping ice-shelf flow with interferometric synthetic aperture radar stacking

International audienc

Estimating the impact of randomised control trial results on clinical practice: results from a survey and modelling study of androgen deprivation therapy plus radiotherapy for locally advanced prostate cancer

Background Recent trials have shown that the addition of external beam radiotherapy (EBRT) to androgen deprivation therapy (ADT) improves survival among men with locally advanced prostate cancer. Objective To examine the potential impact of these trials on changes in clinical practice and life-years saved. Design, setting, and participants A model was developed to examine the impact of changes in clinical practice in the UK. A survey of clinicians who treat men with prostate cancer in the UK and Canada was performed. Measurements Outcomes of interest were the proportion of patients treated with different approaches and the predicted number of life-years saved due to changes in clinical practice. Survey data were cross-tabulated and Pearson's χ2 tests were applied. Results and limitations The survey was completed by 193 clinicians (105 from the UK, 80 from Canada), of whom 70% were clinical/radiation oncologists, 8% were medical oncologists, and 15% were urologists. UK respondents were more likely to report a change in practice in response to the results (44% UK vs 21% Canada). Canadians were more likely to have already been using ADT plus radiotherapy (77% Canada vs 56% UK). The increase in the proportion of patients in the UK treated with ADT + EBRT could result in around 3730–5177 extra life-years at 15 yr from a cohort of 7930 men diagnosed in a single calendar year, compared to if all had been treated with ADT alone. Conclusions Trial findings have changed clinical practice, meaning that men with locally advanced prostate cancer are likely to survive longer. Patient summary Doctors in the UK have changed practice in response to evidence on the superiority of hormone therapy plus radiotherapy to hormone therapy alone. These changes will improve the survival of men with locally advanced prostate cancer. Further reductions in the use of hormone therapy alone could further improve survival

Understanding the passivation layer formed by tolyltriazole on copper, bronze, and brass surfaces

Funding: Lubrizol Ltd is acknowledged for funding and supplying TTAH. EPSRC is acknowledged (EP/L017008/1, EP/T019298/1, and EP/R023751/1) for electron microscopy.Tolyltriazole (TTAH) is used industrially as a corrosion inhibitor for copper alloys, particularly in organic media. In this study, the morphology and chemistry of the layer formed by TTAH on copper and copper alloys under realistic conditions is investigated, with focus on the effects due to the presence of tin or zinc in the substrates. A combination of X-ray photoelectron spectroscopy (XPS), medium energy ion scattering (MEIS), and scanning transmission electron microscopy (STEM) has been used. It was found that an inhomogeneous metal–organic layer forms on the surface of copper specimens, likely in the form of copper nanoparticles surrounded by CuxTTAy complexes. This layer increases in thickness for at least 30 days. Chemically, the copper species in the layer are initially in the +2 oxidation state, but after longer exposure to TTAH, mostly Cu(I) is observed. In bronze samples, tin does not appear to segregate to the surface layer. In brass samples, zinc is depleted from the bulk and forms a thicker ZnxTTAy layer.Peer reviewe

Determinants of Patient Mobility for Prostate Cancer Surgery: A Population-based Study of Choice and Competition.

Many countries have introduced policies that enable patients to select a health care provider of their choice with the aim of improving the quality of care. However, there is little information about the drivers or the impact of patient mobility. Using administrative hospital data (n=19256) we analysed the mobility of prostate cancer patients who had radical surgery in England between 2010 and 2014. Our analysis, using geographic information systems and multivariable choice modelling, found that 33·5% (n=6465) of men bypassed their nearest prostate cancer surgical centre. Travel time had a strong impact on where patients moved to but was less of a factor for men who were younger, fitter, and more affluent (p always < 0.001). Men were more likely to move to hospitals that provided robotic prostate cancer surgery (odds ratio: 1.42, p<0.001) and to hospitals that employed surgeons with a strong media reputation (odds ratio: 2.18, p<0.001). Patient mobility occurred in the absence of validated measures of the quality of care, instead influenced by the adoption of robotic surgery and the reputation of individual clinicians. National policy based on patient choice and provider competition may have had a negative impact on equality of access, service capacity, and health system efficiency. PATIENT SUMMARY: In this study, we assessed the reasons why men would choose to have prostate cancer surgery at a centre other than their nearest. We found that in England men were attracted to centres that carried out robotic surgery and employed surgeons with a national reputation

Determinants of Patient Mobility for Prostate Cancer Surgery: A Population-based Study of Choice and Competition.

Many countries have introduced policies that enable patients to select a health care provider of their choice with the aim of improving the quality of care. However, there is little information about the drivers or the impact of patient mobility. Using administrative hospital data (n=19256) we analysed the mobility of prostate cancer patients who had radical surgery in England between 2010 and 2014. Our analysis, using geographic information systems and multivariable choice modelling, found that 33·5% (n=6465) of men bypassed their nearest prostate cancer surgical centre. Travel time had a strong impact on where patients moved to but was less of a factor for men who were younger, fitter, and more affluent (p always < 0.001). Men were more likely to move to hospitals that provided robotic prostate cancer surgery (odds ratio: 1.42, p<0.001) and to hospitals that employed surgeons with a strong media reputation (odds ratio: 2.18, p<0.001). Patient mobility occurred in the absence of validated measures of the quality of care, instead influenced by the adoption of robotic surgery and the reputation of individual clinicians. National policy based on patient choice and provider competition may have had a negative impact on equality of access, service capacity, and health system efficiency. PATIENT SUMMARY: In this study, we assessed the reasons why men would choose to have prostate cancer surgery at a centre other than their nearest. We found that in England men were attracted to centres that carried out robotic surgery and employed surgeons with a national reputation