99 research outputs found
Computational simulation of round thermal jets in an ambient cross flow using a large-scale hydrodynamic model
Neuronal circuitry for pain processing in the dorsal horn
Neurons in the spinal dorsal horn process sensory information, which is then transmitted to several brain regions, including those responsible for pain perception. The dorsal horn provides numerous potential targets for the development of novel analgesics and is thought to undergo changes that contribute to the exaggerated pain felt after nerve injury and inflammation. Despite its obvious importance, we still know little about the neuronal circuits that process sensory information, mainly because of the heterogeneity of the various neuronal components that make up these circuits. Recent studies have begun to shed light on the neuronal organization and circuitry of this complex region
Development of monosodium acetate-induced osteoarthritis and inflammatory pain in ageing mice
P2Y receptors and pain transmission
It is widely accepted that the most important ATP receptors involved in pain transmission belong to the P2X3 and P2X2/3 subtypes, selectively expressed in small diameter dorsal root ganglion (DRG) neurons. However, several types of the metabotropic ATP (P2Y) receptors have also been found in primary afferent neurons; P2Y1 and P2Y2 receptors are typically expressed in small, nociceptive cells. Here we review the results available on the involvement of P2Y receptors in the modulation of pain transmission
Substance P antagonists as a therapeutic approach to improving outcome following traumatic brain injury
Effects of 15Â weeks of resistance exercise on pro-inflammatory cytokine levels in the vastus lateralis muscle of patients with fibromyalgia
Capsaicin-evoked release of substance P from the spinal cord of NK1 receptor wild type and knockout mice.
Glatiramer acetate attenuates neuropathic allodynia through modulation of adaptive immune cells
Basal and activity-induced release of substance P from primary afferent fibres in NK1 receptor knockout mice: evidence for negative feedback
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