PREPARATION OF SOYPROTEIN BASED NANOPARTICLE

Soy protein based Nanoparticles were prepared via direct graft copolymerisation of soyprotein isolate (SPI)  with ethyl methacrylate at a temperature of 120◦c using benzoyl peroxide as a catalyst. The technique used here was emulsion polymerisation technique. The products obtained ie., the graft copolymer and the homopolymer Poly(ethyl methacrylate)(PEMA) were separated from the product mixture by dissolving the mixture using  chloroform in a separating funnel.The separated graft copolymer in the emulsion form was then spreaded over a glass plate to make a nano plastic sheet and the sheet was allowed to dry for 24 hrs at room temperature to remove chloroform from it. FTIR study confirmed the grafting of SPI and PEMA. XRD studies confirmed the presence of nanoparticles. TG-DTA, Hydrolytic stability, chemical resistivity and water absorption of the sample were studied. Grafting efficiency and grafting percentage of the sample were calculated

QUANTITATIVE PHYTOCHEMICAL DETERMINATIONS AND IN-VITRO CYTOTOXIC ACTIVITY OF MEDICINAL PLANTS

The present study evaluates in-vitro cytotoxic activity of active extracts of medicinal plants. It evaluates anti-cancer activity of most active extracts of I. pes-caprae and C. roseus. This study focuses on the total phenol content and the total flavanoid content of the plant and searches into its medicinal potency based on the total phenol and total flavanoid content. The anti-cancer activity of the extract is found to be more significant than one another. The cytotoxic activity of Ipomoea pes-caprae and C. roseus showed better results. Methanol extracts of aerial and root of Ipomoea pes-caprae possess maximum anticancer activity is found to be 61.77% and 65.55%. Chloroform extract of Catharanthus roseus root was also active against MCF- 7 cells by exhibiting 64.34% of activity. These plants may be a source of new antibiotic compounds.These findings enriches our knowledge of the chemical constituents that are responsible for the medicinal uses of the plant and the anti-cancer potential of selected plants

DOCKING SCORE OF THE ISOLATED COMPOUND: 19-HYDROXY LOCHNERICINE - WITH DIFFERENT PROTEINS

It evaluates the inhibitory effect of the isolated compound with different drug targets for the anti-cancer activities. The present investigation analyses the docking score of the isolated compound with different proteins. Two types of proteins (Drug targets) were chosen against cancer namely Human Epidermal Growth Factor and Crystal structure of human placental aromatase cytochrome P450. This result reveals that the compound 19-Hydroxy lochnericine shows hydrogen interactions with the docking energy of – 7.41 and -7.15 –8.83 kcal/mol. This reveals a significant interaction between the target proteins and the selected compound. Hence, the compound may offer therapeutic advantages in the treatment and prevention of diabetes and breast cancer

MOLECULAR DOCKING STUDY OF NATURALLY OCCURRING COMPOUNDS AS INHIBITORS OF COVID -19

Objectives: The worldwide spread of COVID-19 is an emergent issue to be tackled. Currently, several works in various field have been made in rather short period. The present study aimed to assess bioactive compounds found in medicinal plants as potential COVID-19 Mpro inhibitors using molecular docking study. Methods: The docking analyses were performed by using Autodock, Discovery Studio Visualiser and Igemdock. Results: The binding energy obtained from the docking of 6LU7 with native ligand cupressuflavone is -8.9 kcal/mol. Conclusion: These findings will provide the opportunities to identify the right drug to combat COVID-19

SYNTHESIS AND CHARACTERISATION OF COIR FIBER REINFORCED EPOXY COMPOSITES FROM PUNNAL OIL

Vegetable oil is readily available and inexpensive, can be used to synthesise various types of polymers. In our present study, epoxidised punnal oil has been synthesised from punnal oil via peroxy acetic acid generated ‘insitu’ by treating acetic acid with hydrogen peroxide as oxygen donor. The epoxidation is catalysed by using sulphuric acid. The epoxidation is confirmed by iodine value, oxirane oxygen analysis, fourier transform infrared spectroscopy (FT-IR), nuclear magnetic resonance (NMR) and thin layer chromatography (TLC) analysis.Natural fibers such as jute, sisal, banana, rice husk etc are locally available in abundance and have excellent physical and mechanical properties and can be used more effectively in the development of composite materials for various applications. Epoxy composite samples are prepared from the natural fiber with different ratios using triethylamine hardener and pthaleic anhydride. The mechanical properties viz. tensile strength and the physical properties observed are discussed in detai

SYNTHESIS AND CHARACTERIZATION OF NATURAL FIBRE REINFORCED POLYURETHANE COMPOSITES BASED ON CARDANOL

In recent studies importance has been given to the use of natural products from renewable resources due to the decrease in the supply and price escalations of petroleum raw materials. Cardanol based resole type phenolic resin has been synthesized by condensing cardanol with furfural in a particular mole ratio using dicarboxylic acid catalyst such as phthalic acid. Polyurethane sheets were prepared by treating cardanol furfural resin with 4,41 – methylene bis(cyclohexyl isocyanate)  and the catalyst dibutyltin dilaurate. Natural fibres are prospective reinforcing materials and their use until now has been more traditional than technical.  Among the various fibres sisal is of particular interest in that its composites have high impact strength besides having moderate tensile and flexural properties compared to other fibres.  Fibre reinforced polyurethane composites have been prepared by treating sisal fibre  (10%) into polyurethane. The physico chemical, spectral and thermal properties of polyurethane and fibre reinforced polyurethane composites have been studied

BREAST CANCER ACTIVITY OF ISOLATED COMPOUND FROM TINOSPORA CORDIFOLIA AERIAL

Objectives: The present study undertaken to explore antioxidant and the cell line study of isolated compound from ethanol extract from Tinospora cordifolia belongs to the family Menispermaceae. Methods: The air dried powdered sample of aerial parts of T. cordifolia was extracted in a Soxhlet using five different solvents. Most active ethanol extracts were purified using silica gel column chromatography. Characterized the structure of the isolated compound using Fourier transform infrared spectrum, 1H nuclear magnetic resonance, and liquid chromatography–mass spectrometry studies. Antioxidant and anticancer activity of isolated compound was determined using 2,2-diphenyl-1-picrylhydrazyl and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Results: Magnoflorine was isolated from most active ethanol extract from aerial parts of T. cordifolia which shows maximum antioxidant activity 64% at the tested concentration 500 μg/ml. The percentage of cell viability varied from 53.3% at the minimum tested concentration 3.12 μg/ml to 1.9% at the maximum tested concentration 100 μg/ml. Conclusion: The isolated characterized compounds would be useful to prepare plant-based pharmaceutical preparation to treat various diseases linked with human diseases

1st National Conference on Innovations in Chemical Sciences & Technology (Abstract Proceedings)

We the Department of Chemistry, Scott Christian College (Autonomous) put forth the National Conference on Innovations in Chemical Sciences and Technology NCICST- 2015 covering the concepts to update the various version of chemistry. It is the sincere hope of organizers of NCICST 2015 that the deliberations and proceedings of the conference will be fruitfully utilized by researchers in forthcoming days. I take this opportunity to express my gratitude to all the organizers and faculty members of the Department of Chemistry for their sincere efforts. And I will feel grateful if this conference could contribute its mile to the world and society to bring up prosperity and enlightenment.Dr.A.Malar Retna Convener NCICSTTranslated in MalayKami Jabatan Kimia, Christian College Scott (Autonomi) putforth Persidangan Kebangsaan Inovasi dalam Sains Kimia dan Teknologi NCICST- 2015 meliputi konsep untuk mengemaskini versi pelbagai kimia. Adalah menjadi harapan ikhlas penganjur NCICST 2015, bahawa pertimbangtelitian dan prosiding persidangan itu akan fruitfully digunakan oleh penyelidik dalam hari keluar akan datang.Saya mengambil kesempatan ini untuk mengucapkan terima kasih kepada semua pihak penganjur dan fakultianggota Jabatan kimia untuk usaha-usaha ikhlas mereka. Aku akan bersyukur jika persidangan ini boleh menyumbang batu kepada dunia dan masyarakat untuk membawa kemakmuran dan penyedaran

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INTRODUCTION: Plants have proved to be significant natural resources for medicines; documentation of their use in medicine originates from ancient times. Ethnobotanical and ubiquitous plants provide a rich resource for natural dru