Efficacy and safety of netakimab therapy in patients with moderate to severe psoriasis in real clinical practice

Rationale. Data from randomized clinical trials (RCTs) may differ from the results of the efficacy and safety of medicines in the conditions of daily work. Purpose. To obtain data on the long-term efficacy and safety of the use of the genetically engineered biological drug netakimab in real clinical practice. Methods. In everyday clinical practice, a multicenter non-interventional observational study BCD-085-NIS-01 (ORION) was conducted, which involved 260 adult patients with moderate to severe psoriasis. Results. It was established that the survival rate of genetically engineered biological therapy of netakimab, when analyzing data of 104 weeks of observation, remains high both in bionaive patients and in persons who have previously received treatment for this dermatosis using monoclonal antibodies. The long-term safety profile of netakimab in real clinical practice is comparable to data previously obtained in RCTs and remains favorable for follow-ups up to 2 years. Conclusion. Therapy with GIBA netakimab using a standard dose of 120 mg and regimen in patients with psoriasis is effective and safe for 104 weeks

Calculation of a uniform gas ow from the heated tungsten plate surface

At INP SB RAS, various mechanisms for the erosion of tungsten samples during the pulsed heating were studied. Data were obtained that made it possible to analyze the experimental results of the surface temperature dynamics taking into account the cooling due to the vaporation in vacuum. A numerical model was developed for the effect of a powerful pulsed electron beam on tungsten, which includes the Stefan problem for determining the temperature distribution in a sample and the system of gas dynamics equations. The gas dynamics system is implemented by the two methods of first order of accuracy: the upwind scheme and Belotserkovsky's coarse particle method. For the program veri cation, a test solution of the gas decay was used. In the process of calculating the problem in a complete statement, an analysis of the residual was carried out

Ratiometric Singlet Oxygen Sensor Based on BODIPY-DPA Dyad

Compounds sensitive to reactive oxygen species are widely used in the study of processes in living cells and in the development of therapeutic agents for photodynamic therapy. In the present work, we have synthesized a dyad in which the BODIPY dye is chemically bound to 9,10-diphenylanthracene (DPA). Here, DPA acts as a specific sensor of singlet oxygen and BODIPY as a reference dye. We studied the photophysical properties of the BODIPY-DPA dyad and showed that energy transfer occurs between the chromophores. As a result, the compound has excitation maxima in the absorption region of both DPA and BODIPY, but the fluorescence emission occurs mainly from BODIPY. In the presence of singlet oxygen, the excitation maximum of DPA decreases, while the intensity of the excitation maximum of BODIPY remains almost unchanged. This allows the BODIPY-DPA dyad to be used as a ratiometric sensor of singlet oxygen