Clinical Application of Coagulation Biomarkers

Coagulopathy is of intense interest in the fields of emergency medicine, with many recent studies of coagulation biomarkers for clinical use. The occurrence of disseminated intravascular coagulation (DIC) also resulted in the activation of studies about the coagulopathy. At present DIC has been admitted in many clinical conditions and many coagulation biomarkers have been studied. Fibrin degradation product (FDP) and D-dimer are one type of coagulation biomarker. A characteristic of FDP and D-dimer is the rapid and dynamic elevation of their levels when fibrinolysis occurs in several acute diseases. In this chapter, we present the clinical application of FDP and D-dimer. In trauma, FDP and -dimer have been used for the evaluation of trauma severity, to predict the likelihood of hemorrhage and to evaluate the need for the transfusion of packed red blood cells. In cardiac pulmonary arrest (CPA), FDP and D-dimer have been useful for predicting the return of spontaneous circulation. Thus, the measurement of coagulation biomarkers is useful in the diagnosis and/or treatment of trauma and CPA

Very Long Baseline Array Imaging of Parsec-scale Radio Emissions in Nearby Radio-quiet Narrow-line Seyfert 1 Galaxies

We conducted Very Long Baseline Array (VLBA) observations of seven nearby narrow-line Seyfert 1 (NLS1) galaxies at 1.7 GHz (18cm) with milli-arcsecond resolution. This is the first systematic very long baseline interferometry (VLBI) study focusing on the central parsec-scale regions of radio-quiet NLS1s. Five of the seven were detected at a brightness temperature of >~5x10^6 K and contain radio cores with high brightness temperatures of >6x10^7 K, indicating a nonthermal process driven by jet-producing central engines as is observed in radio-loud NLS1s and other active galactic nucleus (AGN) classes. VLBA images of MRK 1239, MRK 705, and MRK 766 exhibit parsec-scale jets with clear linear structures. A large portion of the radio power comes from diffuse emission components that are distributed within the nuclear regions (<~300 pc), which is a common characteristic throughout the observed NLS1s. Jet kinetic powers limited by the Eddington limit may be insufficient to allow the jets escape to kiloparsec scales for these radio-quiet NLS1s with low-mass black holes of <~10^7 M_sun.Comment: 12 pages, 3 figures, 3 tables, accepted for publication in Ap

Magnetization and transport properties in the superconducting Pr2_{2}Ba4_{4}Cu7_{7}O15−δ_{15-\delta} with metallic double-chain

We have reported the effect of pressure on the magnetization, and transport properties in the nominal composition Pr$_{2}$Ba$_{4}$Cu$_{7}$O$_{15-\delta}$ synthesized by a sol-gel technique. A reduction treatment of the as-sintered sample in vacuum causes higher superconductivity achieving $T_{c,on}=\sim 30$ K for $\delta =0.94$. Application of hydrostatic pressure on the oxygen depleted sample enhances its onset temperature up to 36 K at 1.2 GPa, indicating the nearly optimum doping level of the charge carrier in comparison to the pressure dependence of lower $T_{c}$ samples with $\delta =0.45$. Seebeck coefficient of the superconducting sample shows a metallic conduction, followed by a clear drop below $T_{c,on}$ and is in its temperature dependence below 100 K quite different from that of the non-superconducting one. This finding strongly suggests a dramatic change of the electronic state along the CuO double chain due to the reduction treatment for the appearance of superconductivity .Comment: 5 pages,4 figure