Clients' Perceptions Towards IT Security of e-banking in Bosnia and Herzegovina

Main objective of this research is to examine clients’ perceptions in Bosnia and Herzegovina towards IT security of e-banking, to diagnose problems and try to give proper solutions. Survey was prepared based on six variables and specific questions assigned to each variable. Response rate was good and 207 respondents were surveyed.Overall results suggested a slight agreement in general, and they indicated that when it comes to IT security of online banking, several factors including privacy, control and intangible features are highly important for clients of Bosnia and Herzegovina. Clients do not perceive tangible features as important as they actually are. Therefore, banks are those who need to give more effort when it comes to implementation of IT security in online banking. They definitely need to find more effective ways to inform and educate clients about IT security of using online service, and in that way create additional value

Regioselective Transesterifications of Cyclohexanone Derivatives Containing β-Keto and Malonic Ester Moieties

The cyclohexanone derivatives 1–6 containing β-ketoester and α-disubstituted malonic ester moieties in the same molecule were found to undergo regioselective transesterifications with benzyl alcohol giving exclusively β-keto benzyl esters. On the contrary, the acyclic derivatives 9, 10 containing β-ketoester and α-monosubstituted malonic ester groups gave mixtures of transesterified products under the same reaction conditions

Resistance after chronic application of the HDAC-inhibitor valproic acid is associated with elevated Akt activation in renal cell carcinoma in vivo

Targeted drugs have significantly improved the therapeutic options for advanced renal cell carcinoma (RCC). However, resistance often develops, negating the benefit of these agents. In the present study, the molecular mechanisms of acquired resistance towards the histone deacetylase (HDAC) inhibitor valproic acid (VPA) in a RCC in vivo model were investigated. NMRI:nu/nu mice were transplanted with Caki-1 RCC cells and then treated with VPA (200 mg/kg/day). Controls remained untreated. Based on tumor growth dynamics, the mice were divided into “responders” and “non-responders” to VPA. Histone H3 and H4 acetylation and expression of cell signaling and cell cycle regulating proteins in the RCC mouse tumors were evaluated by Western blotting. Tumor growth of VPA responders was significantly diminished, whereas that of VPA non-responders even exceeded control values. Cdk1, 2 and 4 proteins were strongly enhanced in the non-responders. Importantly, Akt expression and activity were massively up-regulated in the tumors of the VPA non-responders. Chronic application (12 weeks) of VPA to Caki-1 cells in vitro evoked a distinct elevation of Akt activity and cancer cells no longer responded with cell growth reduction, compared to the short 2 week treatment. We assume that chronic use of an HDAC-inhibitor is associated with (re)-activation of Akt, which may be involved in resistance development. Consequently, combined blockade of both HDAC and Akt may delay or prevent drug resistance in RCC

Publication of original research in urologic journals - a neglected orphan?

The pathophysiologic mechanisms behind urologic disease are increasingly being elucidated. The object of this investigation was to evaluate the publication policies of urologic journals during a period of progressively better understanding and management of urologic disease. Based on the ISI Web of Knowledge Journal Citation Reports and the PubMed database, the number and percentage of original experimental, original clinical, review or commentarial articles published between 2002–2010 in six leading urologic journals were analyzed. “British Journal of Urology International”, “European Urology”, “Urologic Oncology-Seminars and Original Investigations” (“Urologic Oncology”), “Urology”, “The Journal of Urology”, and “World Journal of Urology” were chosen, because these journals publish articles in all four categories. The publication policies of the six journals were very heterogeneous during the time period from 2002 to 2010. The percentage of original experimental and original clinical articles, related to all categories, remained the same in “British Journal of Urology International”, “Urologic Oncology”, “Urology” and “The Journal of Urology”. The percentage of experimental reports in “World Journal of Urology” between 2002–2010 significantly increased from 10 to 20%. A distinct elevation in the percentage of commentarial articles accompanied by a reduction of clinical articles became evident in “European Urology” which significantly correlated with a large increase in the journal’s impact factor. No clearly superior policy could be identified with regard to a general increase in the impact factors from all the journals. The publication policy of urologic journals does not expressly reflect the increase in scientific knowledge, which has occurred over the period 2002–2010. One way of increasing the exposure of urologists to research and expand the interface between experimental and clinical research, would be to enlarge the percentage of experimental articles published. There is no indication that such policy would be detrimental to a journal’s impact factor

Neki slučajevi kod trasiranja vodenih tokova

Neki slučajevi kod trasiranja vodenih tokova

Perceptions towards IT Security in Online Banking: Croatian Clients vs. Clients of Bosnia and Herzegovina

This study has been completed with a purpose to analyze and compare perceptions of clients of Bosnia and Herzegovina and those of Croatian clients about IT security in online banking, to provide insight into similarities and differences of their view points and to create important set of information for all subjects active in banking industry. Once the survey based on six variables and specific questions assigned to each one of those variables was prepared, results regarding both countries were collected and concluded. Survey was completed in both Bosnia and Herzegovina and Croatia at high response rates. Even 207 respondents replied from Bosnia and Herzegovina, while 203 respondents completed survey from Croatia. Results were analyzed and presented using descriptive statistics. Results indicated that Croatian e-banking users trust to banks when it comes to IT security of online banking much more compared to clients of Bosnia and Herzegovina. It is important to mention that clients of Croatia perceive tangible features as highly significant while Bosnian clients do not perceive tangible features that much important. This proved that Croatian clients are aware of potential security threats and they know their part of responsibility when it comes to handling money online. On the other hand, results from Bosnia and Herzegovina indicated that Bosnian clients have lack of trust in online banking, and lack of awareness about personal tangible aspects that can improve security of personal online banking experience. The main limitation of this study is relatively small sample and too generic approach. Therefore, this study may be perceived as a pilot study for future researchers. The study’s results may be of interest to marketers and managers of banks operating in Bosnia and Herzegovina and Croatia to learn more about their clients’ perceptions towards their e-banking services

4-Amino- and 4-Hydroxycyclohexane-1,1-dicarboxylic Acid Peptides

4-Amino-, 4-oxo-, and 4-hydroxy-cyclohexane-1 ,1-dicarboxylic acids have been inserted into di- and tri-peptides containing glycine, L-phenylalanine, L-cyclohexylalanine, and L-tyrosine. The geometries of 4-c-(IX A) and 4-t-(IX B) benzamidocyclohexane- r-1-carboxy-1-carbonyl-L-phenylalanine methyl esters and 4-c- -(XXIII A) and 4-t-(XXIII B) benzoxycyclohexane-r-1 -carbomethoxy- 1-carbonyl-L-cyclohexylalanine methyl esters were confirmed by their NMR spectra and intramolecular cyclisations of the cis isomers. The ring opening of 2-oxabicyclo[2.2.2]octan-3-one- 4-carbonyl-L-cyclohexylalanine methyl ester (XXIV) in methanolic hydrochloric acid afforded 4-c-hydroxycyclohexane-r- 1- -carbomethoxy-1-carbonyl-L-cyclohexylalanine methyl ester (XXI A) which on benzoylation was converted into the product identical with the isomer (XXIII A)