193 research outputs found

    Clamping the Mec1/ATR checkpoint kinase into action

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    Utjecaj termo-mehaničke obrade mosobambusa (Phyllostachys pubescens) na njegovu sorpciju i fizičko-mehanička svojstva

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    The aim of this study was to examine some properties of heat-treated (200 °C) and densified (treated) bamboo. Density (ρ), equilibrium moisture content (EMC), sorption hysteresis (H), swelling (S), and Brinell hardness (HB) were examined and compared with untreated bamboo (Phyllostachys sp.) and common oak (Quercus robur L.). The density of heat-treated bamboo (ρ = 1170 kg/m3) was higher than that of untreated bamboo (ρ = 850 kg/m3) and oak wood (ρ = 670 kg/m3). The sorption isotherms were parameterized with the Guggenheim-Anderson-deBoer (GAB) model. Treated bamboo showed lower EMC than untreated bamboo and oak wood in the entire hygroscopic range. The swelling anisotropy index of treated bamboo was the lowest (1.09). The mean HB of treated bamboo (HB=132 MPa) was significantly higher than that of oak and untreated bamboo.Cilj ovog rada bio je istražiti neka svojstva toplinski obrađenoga (200 °C) i ugušćenog (obrađenog) bambusa. Ispitivana je gustoća bambusovih uzoraka (ρ), ravnotežni sadržaj vode u njima (EMC), histereza sorpcije (H), bubrenje (S) i tvrdoća prema Brinellu (HB), a dobivene su vrijednosti uspoređene s neobrađenim uzorcima bambusa (Phyllostachys sp.) i drvom hrasta lužnjaka (Quercus robur L.). Pokazalo se da je gustoća toplinski obrađenog bambusa (ρ = 1170 kg/m3) veća od gustoće neobrađenih uzoraka bambusa (ρ = 850 kg/m3) i uzoraka hrastovine (ρ = 670 kg/m3). Izoterme sorpcije parametrirane su modelom Guggenheim-Anderson-deBoer (GAB). Obrađeni su uzorci bambusa imali niži ravnotežni sadržaj vode od neobrađenih, kao i od uzoraka hrastovine, i to u cijelom rasponu higroskopnosti. Indeks bubrenja obrađenog bambusa bio je najniži (1,09). Srednja vrijednost tvrdoće prema Brinellu obrađenog bambusa (HB = 132 MPa) bila je značajno veća od tvrdoće prema Brinellu hrastovine i neobrađenog bambusa

    Inicijalna desorpcija reakcijskog drva bukovine

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    The research aimed to obtain empirical data for modeling the initial desorption in reaction wood from the cross-section of the green beech (Fagus sylvatica L.) log. Firstly, we analyzed the chemical composition, macro and microscopic structure of tension and opposite wood tissue. Then, the Equilibrium Moisture Content (EMC) was measured by the Dynamic Vapor Sorption method during the initial desorption. The used air parameters were specific for the mild drying schedule of green beech timber (t = 20, 35, and 50 °C, Relative Humidity (RH) ranging from 95 to 0 %). Relationships between the EMC of reaction wood and drying parameters were modeled using the Response Surface Method (RSM). The tests revealed: different hygroscopic properties of tension and opposite wood, the dependence of EMC value on temperature, and differences between EMC values for initial (first) and second desorption. Moreover, it was confirmed that, during initial desorption, the EMCs of reaction wood are significantly higher than reference EMC data. The differences in the EMC value are up to 0.14 kg/kg (for air with RH above 90 %). The presented polynomial model of the initial desorption of reaction beech wood can improve drying schedules for beech sawn timber with a high amount of reaction tissue.Cilj je ovog istraživanja modeliranje inicijalne desorpcije poprečnog presjeka reakcijskog drva bukve (Fagus sylvatica L.) na temelju empirijskih podatka. Najprije je istražen kemijski sastav drva te je analizirana makroskopska i mikroskopska struktura reakcijskoga i opozitnog drva. Zatim je metodom dinamičke sorpcije pare izmjeren ravnotežni sadržaj vode tijekom inicijalne desorpcije. Drvo je podvrgnuto blagom režimu sušenja (t = 20, 35 i 50 °C, te relativnoj vlažnosti zraka u rasponu od 95 do 0 %). Odnosi između ravnotežnog sadržaja vode reakcijskog drva i parametara sušenja modelirani su metodom odzivne površine. Ispitivanjem su dobivena različita higroskopska svojstva reakcijskoga i normalnog drva, ovisnost ravnotežnog sadržaja vode o temperaturi sušenja te razlike između vrijednosti ravnotežnog sadržaja vode pri inicijalnoj (prvoj) i drugoj desorpciji. Također je potvrđeno da je ravnotežni sadržaj vode reakcijskog drva tijekom inicijalne desorpcije znatno veći od referentnih vrijednosti ravnotežnog sadržaja vode normalnog drva. Razlike u vrijednostima ravnotežnog sadržaja vode kreću se do 0,14 kg/kg (pri relativnoj vlažnosti zraka većoj od 90 %). Prikazani polinomski model inicijalne desorpcije reakcijskog drva bukve može poslužiti za poboljšanje režima sušenja bukove piljene građe s velikim udjelom reakcijskog drva

    Satisfaction and discontent of Polish patients with biological therapy of rheumatic diseases : results of a multi-center questionnaire study

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    Objectives: Biologics are medications widely applied in the management of inflammatory rheumatic diseases. The drugs were found to be effective but their application is associated with some disadvantages. Medication with biologics is relatively expensive, and in Poland, it is carried out in specialized centers. The study was designed to evaluate various aspects of satisfaction and dissatisfaction of Polish patients treated with biologics. Material and methods: An anonymous questionnaire was distributed in 23 Polish rheumatological centers involved in the treatment; 1212 returned questionnaires were used for analysis. Responses were received from 606 patients with rheumatoid arthritis, 427 with ankylosing spondylitis, 117 psoriatic arthritis, and 62 adult patients with juvenile idiopathic arthritis (in whom administration of the drugs had been introduced before they were 18 years old). The investigated group constituted about one-fifth of all rheumatic patients on biologics in Poland. Results: A beneficial or very beneficial influence of the medication on the state of physical health was found mostly in patients with rheumatoid arthritis (51.3 and 30.5%) and ankylosing spondylitis (51.0 and 36.8%). Family life was improved by the treatment especially in patients with ankylosing spondylitis (40.7 and 35.6% beneficial and very beneficial, respectively), sleep quality and sexual life mostly in those with ankylosing spondylitis (beneficial/very beneficial influence 41.5/38.4, and 38.7/23.9, respectively). There was a rather small influence of biological treatment on the financial situation of the patients. In general, satisfaction with the treatment was evaluated as positive or very positive in 88% of all investigated patients. In a significant part of the patients, transportation to the medical center was considered as a disadvantage of the treatment. About one-third of the patients considered laboratory and imaging tests to be done before initiation of the medication as a difficulty, and for about 40% waiting time for qualification for the medication was a significant disadvantage. The route of drug administration was without importance for 4/5 of the patients. Conclusions: Summing up, the results were similar in the patients suffering from various diseases although those with psoriatic arthritis felt the highest satisfaction (possibly due to the positive aesthetic effect), and those with ankylosing spondylitis had significant improvement in sexual life (probably due to younger age). Relatively low satisfaction was found in patients with juvenile idiopathic arthritis. There was a small influence of medication on financial status of the patients. Application of biologics has few disadvantages and most of them are associated with the organization of health services (waiting time for the tests, transportation to the medical centers)

    Medycyna i Społeczeństwo. Materiały konferencyjne

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    Ze wstępu: "Z inicjatywy i pod patronatem Krakowskiej Szkoły Wyższej im. Andrzeja Frycza Modrzewskiego w Krakowie odbyła się w styczniu 2003 r. konferencja naukowa lekarzy, farmaceutów, biochemików, filozofów, fizjopatologów, farmakologów i klinicystów, których rozważania skupiały się wokół obszernego tematu „MED YCYNAISPOŁECZEŃSTWO Spotkanie otworzył JM Rektor Prof. KSW dr hab. Zbigniew Maciąg. Rektor wyraził podziękowanie wykładowcom i wyraził głęboką nadzieję, że kolejny numer wydawnictwa Szkoły Acta Academiae Modrevianae, złożony z wybranych prac prezentowanych na konferencji, służył będzie społeczeństwu."(...

    Azimuthal anisotropy of charged jet production in root s(NN)=2.76 TeV Pb-Pb collisions

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    We present measurements of the azimuthal dependence of charged jet production in central and semi-central root s(NN) = 2.76 TeV Pb-Pb collisions with respect to the second harmonic event plane, quantified as nu(ch)(2) (jet). Jet finding is performed employing the anti-k(T) algorithm with a resolution parameter R = 0.2 using charged tracks from the ALICE tracking system. The contribution of the azimuthal anisotropy of the underlying event is taken into account event-by-event. The remaining (statistical) region-to-region fluctuations are removed on an ensemble basis by unfolding the jet spectra for different event plane orientations independently. Significant non-zero nu(ch)(2) (jet) is observed in semi-central collisions (30-50% centrality) for 20 <p(T)(ch) (jet) <90 GeV/c. The azimuthal dependence of the charged jet production is similar to the dependence observed for jets comprising both charged and neutral fragments, and compatible with measurements of the nu(2) of single charged particles at high p(T). Good agreement between the data and predictions from JEWEL, an event generator simulating parton shower evolution in the presence of a dense QCD medium, is found in semi-central collisions. (C) 2015 CERN for the benefit of the ALICE Collaboration. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).Peer reviewe

    Forward-central two-particle correlations in p-Pb collisions at root s(NN)=5.02 TeV

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    Two-particle angular correlations between trigger particles in the forward pseudorapidity range (2.5 2GeV/c. (C) 2015 CERN for the benefit of the ALICE Collaboration. Published by Elsevier B. V.Peer reviewe

    Event-shape engineering for inclusive spectra and elliptic flow in Pb-Pb collisions at root(NN)-N-S=2.76 TeV

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    Elliptic flow of muons from heavy-flavour hadron decays at forward rapidity in Pb-Pb collisions at root s(NN)=2.76TeV

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    The elliptic flow, v(2), of muons from heavy-flavour hadron decays at forward rapidity (2.5 <y <4) is measured in Pb-Pb collisions at root s(NN)= 2.76TeVwith the ALICE detector at the LHC. The scalar product, two- and four-particle Q cumulants and Lee-Yang zeros methods are used. The dependence of the v(2) of muons from heavy-flavour hadron decays on the collision centrality, in the range 0-40%, and on transverse momentum, p(T), is studied in the interval 3 <p(T)<10 GeV/c. A positive v(2) is observed with the scalar product and two-particle Q cumulants in semi-central collisions (10-20% and 20-40% centrality classes) for the p(T) interval from 3 to about 5GeV/c with a significance larger than 3 sigma, based on the combination of statistical and systematic uncertainties. The v(2) magnitude tends to decrease towards more central collisions and with increasing pT. It becomes compatible with zero in the interval 6 <p(T)<10 GeV/c. The results are compared to models describing the interaction of heavy quarks and open heavy-flavour hadrons with the high-density medium formed in high-energy heavy-ion collisions. (C) 2015 CERN for the benefit of the ALICE Collaboration. Published by Elsevier B.V.Peer reviewe

    Pseudorapidity and transverse-momentum distributions of charged particles in proton-proton collisions at root s=13 TeV

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    The pseudorapidity (eta) and transverse-momentum (p(T)) distributions of charged particles produced in proton-proton collisions are measured at the centre-of-mass energy root s = 13 TeV. The pseudorapidity distribution in vertical bar eta vertical bar <1.8 is reported for inelastic events and for events with at least one charged particle in vertical bar eta vertical bar <1. The pseudorapidity density of charged particles produced in the pseudorapidity region vertical bar eta vertical bar <0.5 is 5.31 +/- 0.18 and 6.46 +/- 0.19 for the two event classes, respectively. The transverse-momentum distribution of charged particles is measured in the range 0.15 <p(T) <20 GeV/c and vertical bar eta vertical bar <0.8 for events with at least one charged particle in vertical bar eta vertical bar <1. The evolution of the transverse momentum spectra of charged particles is also investigated as a function of event multiplicity. The results are compared with calculations from PYTHIA and EPOS Monte Carlo generators. (C) 2015 CERN for the benefit of the ALICE Collaboration. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).Peer reviewe
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