An Infrared Cell for Kinetic Studies of Liquid Samples

The construction ,of a th ermostated liquid infrared cell for the temperature range from -1ooc to gooc is described. \u27The cell is designed specifically for the P erkin-Elmer 21 series of double beam infrared spectrophotometers (Perkin-Elmer 21, 221 , 421 and 521), and can be conveniently used for kinetic studies

Biologically active adamantane derivatives

Derivati adamantana prekrivaju vrlo široko područje biološke aktivnosti. U ovom prikazu obrađeni su karakteristični primjeri: virustatici i antiparkinsonici, antibiotici, citostatici, hipoglikernici, antiaritmici i antihipertonici, sedativi i antidepresanti, imunosupresivni agensi i spazmolitici. Veća biološka aktivnost derivata adamantana u odnosu na poznate lijekove posljedica je veće otpornosti prema metabolitičkoj razgradnji, veće lipofilnosti i bržeg transporta kroz membrane stanica.Adamantane derivatives cover a very broad spectrum of biological activities. In this review characteristic examples are described: virustatics and antiparkinsonics, antibiotics, cytostatics, hypoglycemics, sedatives and antidepressants, antiarrythmics and antihypertonics, immunosuppressive agents and spasmolytics. A higher biological activity of adamantane derivatives than that of some known drugs is a consequence of their higher lipophilicity more rapid transport through cell membranes and higher resistance to metabolitic degradation

Approximations to most powerful invariant tests for multinormality against some irregular alternatives

Invariant test, Laplace expansion, Likelihood ratio test, Tests for multinormality, 62H15,