18 research outputs found
Validation of a Multiplex PCR Assay for the Simultaneous Detection of Human Papillomavirus and Chlamydia Trachomatis in Cervical PreservCyt Samples.
The Lantern, 2020-2021
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Comparing breast and lung cancer patients' experiences at a UK Cancer centre: implications for improving care and moves towards a person centred model of clinical practice
Patient surveys are increasingly used to obtain feedback about experiences of care to guide changes in the way services are delivered. We compared the experiences of breast and lung cancer patients at diagnosis, in-patient and outpatient care at a Cancer Centre using a locally adapted version of the Picker Institute Cancer Patient Experience Survey. 65% of breast (82/127) and 65% of lung (75/116) cancer patients responded. Both groups reported good experiences at diagnosis, good support from clinical nurse specialists, and had very positive overall views. Breast patients had slightly poorer experiences of hospital stays while lung patients less often received clinical nurse specialist support and information about other support. Both groups reported that written information was not always provided. 84% (132/157) consented to data on the clinical severity of their condition being used to investigate whether this influenced experiences. This study showed that supportive care policies are being implemented at diagnosis and patients value clinical nurse specialist care. Sufficiently large comparative surveys can identify specific areas of performance for services to focus upon in order to improve quality of care. Patients facing poor prognoses can complete surveys and future studies might explore whether disease stage is associated with differing experiences.<br/
Human Papillomavirus Prevalence and Genotypes in an Opportunistically Screened Irish Female Population
This study aims to evaluate human papillomavirus (HPV) prevalence and predominating genotypes in liquid-based cervical cytology samples from an Irish urban female population. In addition to use of routine cervical cytology testing, women are screened for HPV using the MY09/11 primers for the HPV L1 gene and primers for β-globin amplification in a multiplex format. Overall, 996 women between the ages of 16 and 72 years (average age: 35) are included in the study and HPV prevalence was 19.8%. Cytology results showed that 88.9% were normal, 9% borderline or mild dyskaryosis, 1.1% moderate dyskaryosis and 0.9% severe dyskaryosis. Human papillomavirus prevalence in women under 25 was 31%, reducing to 23% in women in the 25-35 age group and to 11% in women over 35. Human papillomavirus prevalence increased with grade of cytology from 11.4% (normal) through 85.4% (borderline), 84% (mild), 100% (moderate) to 100% (severe dyskaryosis). HPV 16 (20%) and 18 (12%) were the most common high-risk types detected in the study. Other common high-risk types were (in descending order) HPV 66, 33, 53, 31 and 58. HPV 66 was associated with the detection of borderline abnormalities by cytology. This is the first population-based study of HPV prevalence in the normal healthy cervical screening population in the Republic of Irelan
Chronic granulomatous disease presenting as an oculomucocutaneous syndrome mimicking Behcet\u27s syndrome
peer-reviewedA female patient who presented for the first time at the age of 19 with oculomucocutaneous syndrome was found to have an absolute deficiency of neutrophil peroxide production. Neutrophil peroxide production as measured by chemiluminescence was zero on stimulation with opsonized zymosan. Direct membrane stimulation with FMLP and calcium ionophore also failed to elicit peroxide production. The diagnosis of chronic granulomatous disease should be considered in young patients with oculomucocutaneous syndrome
Maintaining Breast Cancer Specimen Integrity and Individual or Simultaneous Extraction of Quality DNA, RNA, and Proteins from Allprotect-Stabilized and Nonstabilized Tissue Samples
info:eu-repo/semantics/publishe