9 research outputs found
Using Osmolarity to Diagnose Dry Eye: A Compartmental Hypothesis and Review of Our Assumptions
Assessment of Tear Meniscus with Optical Coherence Tomography in Thyroid-Associated Ophtalmopathy
Interexaminer Reproducibility of Optical Coherence Tomography for Measuring the Tear Film Meniscus
Optical Coherence Tomography for Measuring the Tear Film Meniscus: Correlation with Schirmer Test and Tear-Film Breakup Time
Is optical coherence tomography an effective device for evaluation of tear film meniscus in patients with acne rosacea?
Do parafluvial zones have an impact in regulating river pollution? Spatial and temporal dynamics of nutrients, carbon, and bacteria in a large gravel bar of the Doubs River (France)
The relationship between clinical signs and dry eye symptoms
Purpose
To evaluate (i) the relationship between traditional and new clinical tests (lid-wiper epitheliopathy (LWE), lid-parallel conjunctival folds (LIPCOF)) and dry eye symptoms in non-contact lens wearers, and (ii) that a combination of these tests can improve predictive ability for the development of dry eye symptoms.
Methods
Tear meniscus height (TMH), non-invasive break-up time (NIBUT), ocular hyperaemia, LIPCOF, phenol red thread test (PRTT), corneal and conjunctival staining, and LWE grades were observed in a cohort of 47 healthy, non-lens wearers (male=17, female=30, median age=35 years, range=19–70). Symptoms were assessed using the Ocular Surface Disease Index (OSDI).
Results
LWE was significantly correlated to both temporal and nasal LIPCOF (0.537−0.248, P|0.31|; P<0.05). Significant discriminators of OSDI+/− were NIBUT (area under the receiver operative characteristic curve (AUC)=0.895), TMH (0.715), PRTT (0.781), LIPCOF (temporal/nasal/Sum 0.748/0.828/0.816), and LWE (0.749). Best predictive ability was achieved by combining NIBUT with nasal LIPCOF (AUC=0.944).
Conclusions
The individual tests NIBUT, TMH, PRTT, LIPCOF, and LWE were significantly, but moderately, related to OSDI scores. The strongest relationship appeared by combining NIBUT with nasal LIPCOF