Identify and Analysis of Performance Evaluation Indicators of Iranian Goalball Coaches

Assessment of performance in the sports industry is an important issue which has attracted the attention of many researchers. One of the important human resources that have a prominent role in the success of sports organizations are coaches and especially club coaches that smallest decisions of them can affect the performance of the entire organization. The purpose of this study was to explore the most important criteria for evaluating the performance of Goalball coaches in Iran. The population consists of all coaches and head coaches and players working in Iran professional Goalball leagues. According small size of the population, sample was considered statistically equal that finally 37 coach and 110 Goalball players (total of 147) questionnaires were collected for data analysis. In this study, a researcher made questionnaire was used. The factors in performance evaluating of Goalball in perspective of coaches were behavioral factor, technical-education factor, team and individual management, experience factor and finally preservation and promotion of team, respectively. Results showed that there are significant differences between coaches and players in combination of education, experience and the management team and individual. But there was no significant difference between the views of coaches and players in the rest. The most important factor in performance evaluating of coaches was technical-education factors, researcher offer to club managers, only by the number of wins and losses of their coaches, not to choose or dismiss their coaches and use from sub-component obtained for choose or dismiss their coaches

Predicting depression, anxiety, stress and academic procrastination based on smartphone addiction with emphasis on gender differences in students

Excessive use of smartphones is associated with academic procrastination, depression, anxiety and stress in students; Therefore, examining the relationship between smartphone addiction and procrastination and psychological vulnerability in students is of particular importance. Therefore, this study was conducted to predict depression, anxiety, stress and academic procrastination based on smartphone addiction with emphasis on gender differences in students. The present study was a descriptive correlational study. Using the stratified sampling method, 275 students (120 girls and 155 boys) of the first year high school students in Turkmanchay who were selected in the academic year 1399-1400. Research data were collected using Solomon and Rathblum (1984) Delayed Questionnaire, Mobile Phone Addiction Questionnaire (2013) and Depression, Anxiety and Stress Scale (DASS-21). The results of Pearson correlation coefficient showed that between smartphone addiction with depression (r = 0.457), anxiety (r = 0.363), stress (r = 0.334) and academic procrastination (0.358) = r) There is a positive and significant relationship (P≥0.001). The results of multiple regression showed that in female students, desire for loneliness and creativity and in male students, desire and loneliness were the strongest predictors of depression, anxiety and stress. Also the strongest predictors of procrastination in female students were loneliness and de-creativity and in post-students loneliness. It can be concluded that addiction to mobile smartphones increases the level of stress and anxiety in students and stress and anxiety caused by addiction to smartphones also increases the level of procrastination among student

Harnessing the TP53INP1/TP53I3 axis for inhibition of colorectal cancer cell proliferation through MEG3 and Linc-ROR Co-expression

Dysregulation of long noncoding RNAs (lncRNAs), such as maternally expressed gene 3 (MEG3) and long intergenic noncoding RNA regulator of reprogramming (linc-ROR), plays a crucial role in colorectal cancer progression. We aimed to assess linc-ROR silencing and MEG3 activation on the colorectal cancer cell proliferation simultaneously; and explore the underlying mechanisms in the TP53-associated Pathway.The MEG3 and linc-ROR shRNA were cloned under the bidirectional CEA promoter (UM1). Subsequently, additional vectors were constructed to express linc-ROR shRNA (UM2) and MEG3 (UM3). After transfecting colorectal cancer cell lines with these recombinant vectors, experiments on cell viability, apoptosis, and cell cycle analysis were conducted. Furthermore, TP53's transcriptional activity and associated genes were assessed using quantitative real-time polymerase chain reaction (qRT-PCR).Interestingly, UM1 significantly inhibited the proliferation of both cell lines than UM2 and UM3. In response to UM1, TP53 transcript remarkably increased in HCT116 cells (10.46) than SW480 cells (6.16); which resulted in up-regulation of TP53INP1, TP53I3, GDF15, CCKN1A and BAX, and down-regulation of G1 cyclins (D1, E1). The rate of apoptosis increased in HCT116 (36.35 %) and SW480 (16.64 %) cells than control. Moreover, UM1-transfected HCT116 cells exhibited a notable arrest in the G0/G1 phase, accompanied by a reduction in the G2/M cell population.Compared to unidirectional vectors, the concurrent targeting approach enhanced TP53 activation at the transcription level. The cell response to UM1 resulted in rapid upregulation of TP53, leading to inhibition of cell proliferation, increased apoptosis, and cell cycle arrest. These findings suggest that the synergistic effect of targeting both MEG3 and linc-ROR could serve as a promising therapeutic strategy for TP53-associated colon cancer

The Impact of Fasting on Metabolic and Anthropometric Parameters in Type II Diabetic Patients: A Prospective Observational Study

Introduction: Fasting has certain effects on metabolic and anthropometric parameters in diabetic patients. It is therefore, necessary for patients to receive proper instructions about their physical activities, eating habits, blood glucose monitoring and medications. Aim: To investigate the effects of fasting on metabolic and anthropometric indices in type II diabetic patients. Materials and Methods: This prospective observational study was performed during Ramadan 2018. The study population consisted of 40 type II diabetic patients (33 females and 7 males) who wished to fast. They started to follow given instructions on their physical activity, eating habits, blood glucose monitoring, and medications before Ramadan. Anthropometric variables were measured pre and post-Ramadan. Fasting Blood/Plasma Glucose (FBG/FPG), Glucose 2 Hour Postprandial (2h PPG), glycosylated haemoglobin (HbA1c), and the lipids profile were assessed before and after Ramadan. FPG and 2h PPG were also evaluated on the fifteenth day of Ramadan. Data were presented as mean±SD. Paired t-test was employed and a p-value of <0.05 was considered statistically significant. Results: After completion of the study, anthropometric variables of patients, including weight (74.9±12.7 vs. 73.0±13.1 kg, p<0.001), BMI (29.9±5.2 vs. 29.0±5.1 kg/m2 , p=0.042), waist circumference (106.2±11.8 vs. 105.3±11.6 cm, p<0.001), conicity index (9.94±0.96 vs 9.80±0.99, p=0.085), systolic blood pressure (118.5±10.6 vs. 113.8±9.4 mmHg, p=0.018), Diastolic blood pressure (72.0±7.9 vs. 68.3±7.0 mmHg, p=0.02) and FPG (125.1±27.4 vs. 105.2±21.4 mg/dL, p<0.001) decreased significantly. However, serum triglyceride increased significantly (127.5±45.5 vs. 166.5±53.5 mg/dL, p<0.001) after fasting compared to pre-Ramadan measurements. Changes in other variables were not statistically significant. Conclusion: The results of this study indicate that fasting had beneficial effect on fasting blood glucose level and anthropometric parameters in type II diabetic patients

Advanced Manufacturing Centres, Practical Model to Boost Technology Transfer in Manufacturing

Establishing collaboration strategies with interdisciplinary networks in research is a crucial success factor for the companies in any sector, especially in manufacturing for aeronautics. In the aeronautical supply chain, Small and Medium-sized Enterprises (SMEs) lack of these types of alliances with universities and other research institutions, which could give them access to shared and specialized knowledge, may strictly limit those companies to learning from their own experience. One way to break this dynamic for industrial companies is to be an active part of research, development, and innovation centres. In this paper, a study to create new advanced manufacturing centres is presented, centres whose activities are focused on Technology Readiness Levels (TRL) 5-7. The approach is based on a project management methodology, and it is applied to the aeronautical sector in the Basque Country. An initial study of the international experience and state of the art in this type of facility, as well as an analysis of the current socioeconomic environment of the Basque Country are presented. A benchmark study was done to identify the key processes that this centre must promote for this initiative to succeed, or those areas of knowledge that can make or break the initiative. Finally, the results showed a definitive picture for establishing an advanced manufacturing centre in the Basque Country. This work lays both the foundations of knowledge in the sector and the difficulties noted, so it can serve as guidance for similar initiatives.We thanks the strong support to the centre of the Basque Government (Dept of Economic development and infrastructures and SPRI) and Council of the Province of Biscay, Technological park of Zamudio and University of the Basque Country. Special thanks to Eng. Alfredo Lopez-Diez for the ideas and daily efforts to develop the centre model along with ITP Aero, Danobat Group and the other 76 company partners. Thanks are due to Joserra Otegi from UPV/EHU and funds from Excellence groups of the Basque university system no. IT1337-19 (from Basque Government). Centre CFAA can be looked up at: https://www.ehu.eus/en/web/CFAA/hom

Quantitative expression analysis of TaSOS1 and TaSOS4 genes in cultivated and wild wheat plants under salt stress

Salt stress is a mixture of ionic, osmotic, and oxidative stresses. The expression of TaSOS1 (a transmembrane Na(+)/H(+) antiporter) and TaSOS4 [a cytoplasmic pyridoxal (PL) kinase] genes were measured in four different salinity levels and different time courses of salinity exposure using qRT-PCR technique. Mahuti (salt tolerant) and Alamut (salt sensitive) cultivars were used as cultivated wheat, and T. boeticum and Aegilops crassa as wild wheat plants. Salt-induced expression of TaSOS1 in these wild wheat plants indicates the presence of active TaSOS1 gene on the genomes A and D. The TaSOS1 and TaSOS4 transcript levels were found to be downregulated after salt treatment in all cultivars except in A. crassa, which was in contrast with its expression pattern in roots that was being upregulated from a very low-basal expression, after salt treatments. Duncan's Multiple Range Test showed a significant difference between expression in the 200-mM NaCl concentration with the 50 and 100 mM for the TaSOS1 gene, and no significant difference for TaSOS4. Lack of significant correlation between the TaSOS1 and TaSOS4 gene expressions confirms the theory that PLP has no significant effect on the expression of the TaSOS1 gene in wheat leaves.Amin Ramezani, Ali Niazi, Ali Asghar Abolimoghadam, Mahboobeh Zamani Babgohari, Tahereh Deihimi, Mahmod Ebrahimi, Hosein Akhtardanesh, Esmail Ebrahimi