Polyphenols: Nature's Gift as dietary phytoconstituents against different human ailments

Recently, researches and scientists are showing a lot of interests in bioactive compounds of plants and its products as these constituents are of high valued. Polyphenols are phytochemical constituents which are the integral components in plants and their products that are associated with defensive mechanism against infections and various oxidative stress by free radicals. Green tea, fruits, vegetables, cereals and red wines are rich sources of polyphenolic constituents which attributes prevention from infections and diseases because of its antioxidant properties, anti-diabetic properties, and radical scavenging properties. Oxidative stress which is the primary reason for different ailments in humans is due to the free radicals that are present even during the normal health condition. Polyphenolic acids like cinnamic acid, romarinic acid, stilbenes like resveratrol, flavonoids like catechin, taxifolin, quercetin, and lignans like sesamin, pinoresinol, podophyllotoxin etc. are found to be effective against wide range of human diseases like oxidative stress, cardiovascular disorder, neurodegenerative diseases, aging, and cancer. These phytoconstituents prevent the diseases and provide relieving sensation via different mechanisms. Here, the study shows the importance of polyphenols with respect to the relevance of human health. As there are the promising applications of various bioactive constituents in a wide range of disease, further research should be encouraged on the mechanism of action and bioavailability of polyphenols

Knowledge and Practice regarding Menstrual Hygiene among Physically Disabled Women in Kathmandu, Nepal

Background: Disability is the condition of difficulty in carrying out daily activities normally and in taking part in social life due to problems in parts of the body and the physical system. Disability also carries stigma, so disabled people may face layers of discrimination when they are menstruating. The objective of the review is to assess the menstrual hygiene practice of disabled women, the barriers they face, and the available interventions to help them manage their menstruation hygienically and with dignity. Method: This was a cross-sectional descriptive study that was conducted among 151 physically disabled peoples.Self-structured questionnaire and face-to-face interview was used as data collection tools and techniques. Data entry and analysis was done using SPSS 16.0. The results of the study were presented with the help of tabular description using the same software along with Microsoft word and excel 2007. Results: Most of respondents knew the 26-30 days as normal cycle duration (80.13%). Majority of respondents had reported that they do not go to holy places (91.39%) and should not cook food (94.03%) during menstruation. Most of respondents had stayed (96.68%) and eat (98.01%) at same place and 31.38% of respondents had bath daily during menstruation. 83.44% of respondents used sanitary while 69.53 % of respondents changed pad twice a day. Maximum number of the respondents 91.39% disposed sanitary pad in dustbin. 87.41% of respondents learned about menstrual hygiene from parents. Conclusions: Good and satisfactory knowledge about menstrual hygiene was found among age group 15-24years. This study on menstrual hygiene management behaviour and practices covered all categories of females in the Kathmadnu region., i.e. girls and women in both school and rehabilitation areas, educated women (from primary to university level), non-literate women, girls, women of reproductive age women. Keyword: Knowledge, practice, menstrual hygiene and physically disable