An observational study of clinicoetiological profile of stroke patients in a new tertiary care hospital in North Odisha, India

Background: Stroke is one of the leading causes of morbidity and mortality in India. The objective was to study the clinical profile, risk factors, neurological characters, pattern of brain stroke, areas of brain affected as per CT scan findings in patients with stroke.Methods: This observational study was carried out from June 2018 to Jan 2019 of all new patients admitted with stroke in Pandit Raghunath Murmu Medical College and Hospital, Baripada, Mayurbhanj, Odisha, India.Results: The incidence of stroke is maximum in 46-60 years of age group. The average age+SD was 59.3+13.5 in our study. 274 (46.52%) patients had ischemic stroke and 315 (53.48%) patients had hemorrhagic stroke. The male to female ratio was 1.46:1. Anterior circulation (86.42%) was the most common territory involved in the brain. The most common risk factor was hypertension with 77.76% followed by dyslipidemia (53.99%). The most common clinical presentation was hemiplegia (85.23%).Conclusions: The incidence of stroke is maximum in 46-60 years of age group. The average age+SD was 59.3+13.5 in our study. 274 (46.52%) patients had ischemic stroke and 315 (53.48%) patients had hemorrhagic stroke. The male to female ratio was 1.46:1. Anterior circulation (86.42%) was the most common territory involved in the brain. The most common risk factor was hypertension with 77.76% followed by dyslipidemia (53.99%). The most common clinical presentation was hemiplegia (85.23%).

Canonical quantization of the relativistic particle in static spacetimes

We perform the canonical quantization of a relativistic spinless particle moving in a curved and static spacetime. We show that the classical theory already describes at the same time both particle and antiparticle. The analyses involves time-depending constraints and we are able to construct the two-particle Hilbert space. The requirement of a static spacetime is necessary in order to have a well defined Schr\"odinger equation and to avoid problems with vacuum instabilities. The severe ordering ambiguities we found are in essence the same ones of the well known non-relativistic case.Comment: Revtex, 9 page

Evaluation of the Immunoprotective Potential of Recombinant Paraflagellar Rod Proteins of Trypanosoma evansi in Mice

Trypanosomosis, caused by Trypanosoma evansi, is an economically significant disease of livestock. Systematic antigenic variation by the parasite has undermined prospects for the development of a protective vaccine that targets the immunodominant surface antigens, encouraging exploration of alternatives. The paraflagellar rod (PFR), constituent proteins of the flagellum, are prominent non-variable vaccine candidates for T. evansi owing to their strategic location. Two major PFR constituent proteins, PFR1 (1770bp) and PFR2 (1800bp), were expressed using Escherichia coli. Swiss albino mice were immunized with the purified recombinant TePFR1 (89KDa) and TePFR2 (88KDa) proteins, as well as with the mix of the combined proteins at equimolar concentrations, and subsequently challenged with virulent T. evansi. The PFR-specific humoral response was assessed by ELISA. Cytometric bead-based assay was used to measure the cytokine response and flow cytometry for quantification of the cytokines. The recombinant TePFR proteins induced specific humoral responses in mice, including IgG1 followed by IgG2a and IgG2b. A balanced cytokine response induced by rTePFR 1 and 2 protein vaccination associated with extended survival and improved control of parasitemia following lethal challenge. The observation confirms the immunoprophylactic potential of the covert antigens of T. evansi

U(1,1)--Invariant Generation of Charges for Einstein--Maxwell--Dilaton--Axion Theory

The action of the isometry subgroup which preserves the trivial values of the fields is studied for the stationary D=4 Einstein--Maxwell--Dilaton--Axion theory. The technique for generation of charges and the corresponding procedure for construction of new solutions is formulated. A solution describing the double rotating dyon with independent values of all physical charges is presented.Comment: 14 pages, RevTex, no figurie

Exact solutions in two-dimensional string cosmology with back reaction

We present analytic cosmological solutions in a model of two-dimensional dilaton gravity with back reaction. One of these solutions exhibits a graceful exit from the inflationary to the FRW phase and is nonsingular everywhere. A duality related second solution is found to exist only in the ``pre-big-bang'' epoch and is singular at $\tau = 0$. In either case back reaction is shown to play a crucial role in determining the specific nature of these geometries.Comment: Shortened slightly, references added, to appear in Physical Review D (Rapid Communications). 16 pages, RevTex, 3 PostScript figure

Relativistic Mean Field Approach and the Pseudo-Spin Symmetry

Based on the Relativistic Mean Field (RMF) approach the existence of the broken pseudo-spin symmetry is investigated. Both spherical RMF and constrained deformed RMF calculations are carried out employing realistic Lagrangian parameters for spherical and for deformed sample nuclei. The quasi - degenerate pseudo-spin doublets are confirmed to exist near the fermi surface for both spherical and deformed nuclei.Comment: 9 pages RevTex, 4 p.s figures, to appear in Phys. Rev. C as R.

Warped Spectroscopy: Localization of Frozen Bulk Modes

We study the 10D equation of motion of dilaton-axion fluctuations in type IIB string compactifications with three-form flux, taking warping into account. Using simplified models with physics comparable to actual compactifications, we argue that the lightest mode localizes in long warped throats and takes a mass of order the warped string scale. Also, Gukov-Vafa-Witten superpotential is valid for the lightest mass mode; however, the mass is similar to the Kaluza-Klein scale, so the dilaton-axion should be integrated out of the effective theory in this long throat regime (leaving a constant superpotential). On the other hand, there is a large hierarchy between flux-induced and KK mass scales for moderate or weak warping. This hierarchy agrees with arguments given for trivial warping. Along the way, we also estimate the effect of the other 10D supergravity equations of motion on the dilaton-axion fluctuation, since these equations act as constraints. We argue that they give negligible corrections to the simplest approximation.Comment: 24pp + appendices, 6 figs, JHEP3 class; v2. corrected reference; v3. added clarifications; v4. corrected typo

Scattering of Four-Dimensional Black Holes

The moduli space metric for an arbitrary number of extremal black holes in four dimensions with arbitrary relatively supersymmetric charges is found.Comment: 16 pages, REVTeX; references adde

Inhomogeneous Einstein-Rosen String Cosmology

Families of anisotropic and inhomogeneous string cosmologies containing non-trivial dilaton and axion fields are derived by applying the global symmetries of the string effective action to a generalized Einstein-Rosen metric. The models exhibit a two-dimensional group of Abelian isometries. In particular, two classes of exact solutions are found that represent inhomogeneous generalizations of the Bianchi type VI_h cosmology. The asymptotic behaviour of the solutions is investigated and further applications are briefly discussed.Comment: Minor extension of concluding section; 18 pages, to appear in Phys.Rev.

Duality in String Cosmology

Scale factor duality, a truncated form of time dependent T-duality, is a symmetry of string effective action in cosmological backgrounds interchanging small and large scale factors. The symmetry suggests a cosmological scenario ("pre-big-bang") in which two duality related branches, an inflationary branch and a decelerated branch are smoothly joined into one non-singular cosmology. The use of scale factor duality in the analysis of the higher derivative corrections to the effective action, and consequences for the nature of exit transition, between the inflationary and decelerated branches, are outlined. A new duality symmetry is obeyed by the lowest order equations for inhomogeneity perturbations which always exist on top of the homogeneous and isotropic background. In some cases it corresponds to a time dependent version of S-duality, interchanging weak and strong coupling and electric and magnetic degrees of freedom, and in most cases it corresponds to a time dependent mixture of both S-, and T-duality. The energy spectra obtained by using the new symmetry reproduce known results of produced particle spectra, and can provide a useful lower bound on particle production when our knowledge of the detailed dynamical history of the background is approximate or incomplete.Comment: 6 pages, no figures, latex2e using ltwol2e.sty. Based on talks at the 44'th annual meeting of the Israel Physical Society, Apr 8, 1998, Rehovot, Israel, and ICHEP98, 23-29 July, Vancouver, BC, Canada, and second conf. on Quantum Aspects of Gauge Theories, Supersymmetry and Unification, Sept 21-26, 1998, Corfu, Greece. To be published in the proceeding