Fatty acid profile in peri-prostatic adipose tissue and prostate cancer aggressiveness in African-Caribbean and Caucasian patients

BACKGROUND: Genetic and nutritional factors have been linked to the risk of aggressive prostate cancer (PCa). The fatty acid (FA) composition of peri-prostatic adipose tissue (PPAT), which reflects the past FA intake, is potentially involved in PCa progression. We analysed the FA composition of PPAT, in correlation with the ethno-geographical origin of the patients and markers of tumour aggressiveness. METHODS: From a cohort of 1000 men treated for PCa by radical prostatectomy, FA composition of PPAT was analysed in 156 patients (106 Caucasians and 50 African-Caribbeans), 78 with an indolent tumour (ISUP group 1 + pT2 + PSA <10 ng/mL) and 78 with an aggressive tumour (ISUP group 4-5 + pT3). The effect of FA extracted from PPAT on in-vitro migration of PCa cells DU145 was studied in 72 patients, 36 Caucasians, and 36 African-Caribbeans. RESULTS: FA composition differed according to the ethno-geographical origin. Linoleic acid, an essential n-6 FA, was 2-fold higher in African-Caribbeans compared with Caucasian patients, regardless of disease aggressiveness. In African-Caribbeans, the FA profile associated with PCa aggressiveness was characterised by low level of linoleic acid along with high levels of saturates. In Caucasians, a weak and negative association was observed between eicosapentaenoic acid level (an n-3 FA) and disease aggressiveness. In-vitro migration of PCa cells using PPAT from African-Caribbean patients was associated with lower content of linoleic acid. CONCLUSION: These results highlight an important ethno-geographical variation of PPAT, in both their FA content and association with tumour aggressiveness

Population development and breeding success of Dark-bellied Brent Geese Branta b. bernicla from 1991-2011

The Dark-bellied Brent Goose Branta bernicla bernicla is the largest of the six Brent Goose populations, which collectively number around 600,000 birds globally. After a major decline to 16,500 geese in 1958, numbers recovered during the 1970s and 1980s to a peak of c. 330,000 individuals between 1992 and 1994. From 1994 onwards the population declined again to 200,000–250,000. This decline has been attributed to poor breeding, associated with faltering cycles of Siberian Brown Lemming Lemmus sibiricus (predominantly) and Palearctic Collared Lemming Dicrostonyx torquatus abundance on the breeding grounds on the Taimyr Peninsula, where lemmings are a main food resource for potential predators of goslings. Darkbellied Brent Geese only breed well in peak lemming years (Summers & Underhill 1991), and this usually occurs every three years, but the frequent failure since 1994 of lemming numbers to peak (except in 2005) has resulted in the absence of very good breeding years for the geese (Nolet et al. 2013). The mid-winter distribution has shown a marked shift towards France over the last decade. France currently supports 50% of the population in January, Great Britain 35–40%, the Netherlands 15–20%, and Germany and Denmark 2%. In spring, almost the entire population gathers in the Wadden Sea, leaving only 4% of the population in Great Britain, and virtually none in France, with the Dutch part of the Wadden Sea supporting 40–45%, the German section 45–50% and Denmark 6%

Twenty million years of continuous deformation along theKarakorum fault, western Tibet: A thermochronological analysis.

The role of the Karakorum fault zone (KFZ) is debated. South of 33°N, ongoing dextral-oblique slip along the SW edge of the Gar basin exhumes metamorphic and magmatic rocks of the Ayilari range. Minerals have recorded a continuum of deformation from temperatures >600–400°C down to 20 Ma of deformation along the fault. Greenschist facies deformation superimposed upon the medium- to high-grade deformation marks a kinematic change from pure dextral to dextral-normal motion associated with the onset of rapid cooling. At the regional scale, the coexistence of transtension in the Gar basin with transpression documented along the Pangong range farther north suggests another example of the ‘‘zipper tectonics'' model developed along the Red River fault. The kinematic shift induced the rise of the Ayilari range starting at 16–12 Ma and the incision of major river courses. The Indus River might have become captive of the relief at this time. The river's 120 km of apparent offset implies dextral motion at a long-term rate of ca 8.5 ± 1.5 mm/yr

When and where did India and Asia collide?

Timing of the collision between India and Asia is the key boundary condition in all models for the evolution of the Himalaya-Tibetan orogenic system. Thus it profoundly affects the interpretation of the rates of a multitude of associated geological processes ranging from Tibetan Plateau uplift through continental extrusion across eastern Asia, as well as our understanding of global climate change during the Cenozoic. Although an abrupt slowdown in the rate of convergence between India and Asia around 55 Ma is widely regarded as indicating the beginning of the collision, most of the effects attributed to this major tectonic episode do not occur until more than 20 Ma later. Refined estimates of the relative positions of India and Asia indicate that they were not close enough to one another to have collided at 55 Ma. On the basis of new field evidence from Tibet and a reassessment of published data we suggest that continent-continent collision began around the Eocene/Oligocene boundary (∼34 Ma) and propose an alternative explanation for events at 55 Ma. Copyright 2007 by the American Geophysical Union.published_or_final_versio

Cyanobacterial lipopolysaccharides and human health – a review

Cyanobacterial lipopolysaccharide/s (LPS) are frequently cited in the cyanobacteria literature as toxins responsible for a variety of heath effects in humans, from skin rashes to gastrointestinal, respiratory and allergic reactions. The attribution of toxic properties to cyanobacterial LPS dates from the 1970s, when it was thought that lipid A, the toxic moiety of LPS, was structurally and functionally conserved across all Gram-negative bacteria. However, more recent research has shown that this is not the case, and lipid A structures are now known to be very different, expressing properties ranging from LPS agonists, through weak endotoxicity to LPS antagonists. Although cyanobacterial LPS is widely cited as a putative toxin, most of the small number of formal research reports describe cyanobacterial LPS as weakly toxic compared to LPS from the Enterobacteriaceae. We systematically reviewed the literature on cyanobacterial LPS, and also examined the much lager body of literature relating to heterotrophic bacterial LPS and the atypical lipid A structures of some photosynthetic bacteria. While the literature on the biological activity of heterotrophic bacterial LPS is overwhelmingly large and therefore difficult to review for the purposes of exclusion, we were unable to find a convincing body of evidence to suggest that heterotrophic bacterial LPS, in the absence of other virulence factors, is responsible for acute gastrointestinal, dermatological or allergic reactions via natural exposure routes in humans. There is a danger that initial speculation about cyanobacterial LPS may evolve into orthodoxy without basis in research findings. No cyanobacterial lipid A structures have been described and published to date, so a recommendation is made that cyanobacteriologists should not continue to attribute such a diverse range of clinical symptoms to cyanobacterial LPS without research confirmation

Successive deformation episodes along the Lungmu Co zone, west-central Tibet

International audienceField study, thermochronology and geochemistry of the east Lungmu Co (LMC) range highlight some of the geological events that shaped western Tibet. The LMC fault zone has long been interpreted as the boundary between the Tianshuihai terrane of Laurasian affinity and the Qiangtang block of Gondwanian affinity. In the LMC range, the Paleozoic series is intruded by the Mangtsa leucogranite whose zircon have a U/Pb age of 116.9 ± 1 Ma and by mafic rocks with U/Pb zircon ages ranging from 116.9 ± 1 to 95.1 ± 1.7 Ma. Geochemistry of the mafic rocks indicates that they have been emplaced in a supra-subduction zone setting, probably the north dipping Nujiang suture zone. 40Ar/39Ar micas ages of the granite indicate that cooling below ~ 350 °C occurred between 105 and 85 Ma. 40Ar/39Ar K-feldspar data suggest a fast cooling event at 60-55 Ma, which we relate to the reactivation of the LMC suture zone as a thrust at the onset of the India-Eurasia collision. The last, and still active, deformation event corresponds to left-lateral strike-slip faulting along the ENE-WSW LMC fault

Genome scans reveal candidate regions involved in the adaptation to host plant in the pea aphid complex.

Publication Inra prise en compte dans l'analyse bibliométrique des publications scientifiques mondiales sur les Fruits, les Légumes et la Pomme de terre. Période 2000-2012. http://prodinra.inra.fr/record/256699International audienceA major goal in evolutionary biology is to uncover the genetic basis of adaptation. Divergent selection exerted on ecological traits may result in adaptive population differentiation and reproductive isolation and affect differentially the level of genetic divergence along the genome. Genome-wide scan of large sets of individuals from multiple populations is a powerful approach to identify loci or genomic regions under ecologically divergent selection. Here, we focused on the pea aphid, a species complex of divergent host races, to explore the organization of the genomic divergence associated with host plant adaptation and ecological speciation. We analysed 390 microsatellite markers located at variable distances from predicted genes in replicate samples of sympatric populations of the pea aphid collected on alfalfa, red clover and pea, which correspond to three common host-adapted races reported in this species complex. Using a method that accounts for the hierarchical structure of our data set, we found a set of 11 outlier loci that show higher genetic differentiation between host races than expected under the null hypothesis of neutral evolution. Two of the outliers are close to olfactory receptor genes and three other nearby genes encoding salivary proteins. The remaining outliers are located in regions with genes of unknown functions, or which functions are unlikely to be involved in interactions with the host plant. This study reveals genetic signatures of divergent selection across the genome and provides an inventory of candidate genes responsible for plant specialization in the pea aphid, thereby setting the stage for future functional studies

Post 4 Ma initiation of normal faulting in southern Tibet. Constraints from the Kung Co half-graben

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Reply to comment on large scale geometry, offset and kinematic evolution of the Karkorum fault.

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