Chameleon-like elastomers with molecularly encoded strain-adaptive stiffening and coloration

Active camouflage is widely recognized as a soft-tissue feature, and yet the ability to integrate adaptive coloration and tissuelike mechanical properties into synthetic materials remains elusive. We provide a solution to this problem by uniting these functions in moldable elastomers through the self-assembly of linear-bottlebrush-linear triblock copolymers. Microphase separation of the architecturally distinct blocks results in physically cross-linked networks that display vibrant color, extreme softness, and intense strain stiffening on par with that of skin tissue. Each of these functional properties is regulated by the structure of one macromolecule, without the need for chemical cross-linking or additives. These materials remain stable under conditions characteristic of internal bodily environments and under ambient conditions, neither swelling in bodily fluids nor drying when exposed to air

МЕЖДИСЦИПЛИНАРНЫЙ ПЕРСОНАЛИЗИРОВАННЫЙ ПОДХОД И ТЕХНОЛОГИИ ИЗУЧЕНИЯ ГОЛОВНОГО МОЗГА ПРИ ВИЧИНФЕКЦИИ

There was made an attempt to link interdisciplinary research methodically, from clinical diagnostic techniques, modern instrumental, laboratory and basic research to their implementation in practice. The experience of several partner groups studying the brain in HIV infection was analyzed and summarized. It was based on an interdisciplinary approach, the goals and authorities of infectious disease specialists,  psychiatrists, neurologists, radiologists, laboratory doctors, clinical examination algorithm, the role of history and interview, express-diagnostic of cognitive functions, specialized psychiatric, neurological  diagnosis, conclusion of clinical psychologists, indications for radiology methods. The choice and analysis of radiological and instrumental methods, the volume and structure of laboratory methods of central nervous system study were justified. The role of molecular genetic studies of HIV in blood and cerebrospinal fluid, the identification of drug-resistant forms of the virus was determined when choosing the therapy.Сделана попытка методически связать междисциплинарные исследования, начиная с клинических диагностических приемов, современных инструментальных, лабораторных и фундаментальных исследований до их реализации в практике. Проанализирован и обобщен опыт нескольких партнерских коллективов по методологии изучения головного мозга при ВИЧ-инфекции. В основу легли междисциплинарный подход, задачи и полномочия инфекционистов, наркологов-психиатров, неврологов, радиологов, врачей лабораторной службы, алгоритм клинического обследования, роль анамнеза и опроса, экспресс-диагностики когнитивных функций, специализированный диагноз психиатрический, неврологический, заключение клинических психологов, показания для радиологических исследований. Обоснованы выбор и анализ радиологических и инструментальных методов оценки ЦНС, объем и структура лабораторных методов для оценки процессов в ЦНС. Определена роль молекулярно-генетических исследований ВИЧ в крови и спинномозговой жидкости, выявления фармакорезистентных форм вируса, учет при выборе терапии