HPV Vaccine Reminders at the Point of Service: Efficacy and Missed Opportunities. A Claims Based Study within One Health Plan

Introduction: Our objective is to assess HPV vaccine series completion rates, whether on-screen Point of Service reminders (POS) make a difference, and missed opportunities for reminders to have an effect. Methods: Retrospective, claims-based study of females aged 9-26 receiving an initial dose of HPV vaccine during 2 periods: before (period 1) and after (period 2) implementation of a POS reminder system in 1(“Change Group”) of 2 physician groups using EHRs for both periods. Completion rates, and missed opportunities during eligible periods were calculated for those with continuous enrollment in the health plan investigated. Results: Completion rates within 1 year of the 1st dose were Period 1: 47% Change Group vs. 46% Control Group (p=0.847). Period 2: 50% Change group vs. 57% Control Group (p=0.158). No significant improvement occurred between the 2 periods in either group. Differences in 1 year completion rates by specialty of initiating provider or age group (≥18) were not significant. During period 2, among those with continuous insurance plan enrollment in the Change Group, 43 patients received 1 dose and 46 received 2 doses. Of those receiving 1 dose, 30 (70%) had a visit to the same group within an eligible time period (median # visits: 2, range 1-20); of those completing 2 doses, 4 (9%) had a visit to the same group within an eligible period (median # visits: 1, range: 1-3). Among those receiving 1 dose, 25 (58%) had a visit to the same group and same specialty as the initial dose (median # visits: 1, range 1-8); for those having received 2 doses, 3 (6%) had a subsequent visit to same group and specialty (median # visits: 1, range 1-3). Conclusion: POS reminder systems was not associated with improved completion rates. POS reminders are limited by infrequent visits among non-completers in an eligible period

A Rest-frame Optical View on z~4 Galaxies I: Color and Age Distributions from Deep IRAC Photometry of the IUDF10 and GOODS Surveys

We present a study of rest-frame UV-to-optical color distributions for z~4 galaxies based on the combination of deep HST/ACS+WFC3/IR data with Spitzer/IRAC imaging. In particular, we use new, ultra-deep data from the IRAC Ultradeep Field program (IUDF10). Our sample contains a total of ~2600 galaxies selected as B-dropout Lyman Break Galaxies (LBGs) in the HUDF and one of its deep parallel fields, the HUDF09-2, as well as GOODS-North and South. This sample is used to investigate the UV continuum slopes beta and Balmer break colors (J_125-[4.5]) as a function of rest-frame optical luminosity. The [4.5] filter is chosen to avoid potential contamination by strong rest-frame optical emission lines. We find that galaxies at M_z<-21.5 (roughly corresponding to L*[z~4]) are significantly redder than their lower luminosity counterparts. The UV continuum slopes and the J_125-[4.5] colors are well correlated. The most simple explanation for this correlation is that the dust reddening at these redshifts is better described by an SMC-like extinction curve, rather than the typically assumed Calzetti reddening. After correcting for dust, we find that the galaxy population shows mean stellar population ages in the range 10^8.5 to 10^9 yr, with a dispersion of ~0.5 dex, and only weak trends as a function of luminosity. In contrast to some results from the literature, we find that only a small fraction of galaxies shows Balmer break colors which are consistent with extremely young ages, younger than 100 Myr. Under the assumption of smooth star-formation histories, this fraction is only 12-19% for galaxies at M_z<-19.75. Our results are consistent with a gradual build-up of stars and dust in galaxies at z>4, with only a small fraction of stars being formed in short, intense bursts of star-formation.Comment: 11 pages, 10 figures; submitted to Ap

A research-based approach to promote the adoption of novel UK-based concrete test methods in Chinese construction standards

As part of a UK-China Science Bridge project – a UK government funded initiative linking leading universities and businesses in selective partnering countries – in 2009 a collaborative research programme was initiated between Queen’s University Belfast and the Research Institute of High Performance Concrete (part of the Central Research Institute of Building and Construction) in Beijing.The focus of research was concrete permeability assessment; a key factor in determining the potential long-term durability of civil engineering infrastructure. More specifically, a programme of work was designed to allow comparisons between the related test method included in the Chinese construction standards (GB/T50082-2009) and a novel non-destructive test method, the Autoclam Permeability System, developed by researchers at Queen’s University allowing both laboratory- and site-based measurement of air permeability, unsaturated water permeability and water absorption.A programme of 14 concrete mixtures was investigated to assess the influence of water-binder ratio (in the range 0.36-0.60) and binder type (considered was cement, fly ash, slag and silica fume). All mixes were prepared and tested in China using local materials and assessed for slump and compressive strength, in addition to a suite of durability-related parameters using Chinese and UK test methods. Reported in the paper are the positive correlation coefficients attained between the various test methods and on-going work to secure adoption of the Autoclam test method in China

A Spectroscopic Redshift Measurement for a Luminous Lyman Break Galaxy at z=7.730 using Keck/MOSFIRE

We present a spectroscopic redshift measurement of a very bright Lyman break galaxy at z=7.7302+-0.0006 using Keck/MOSFIRE. The source was pre-selected photometrically in the EGS field as a robust z~8 candidate with H=25.0 mag based on optical non-detections and a very red Spitzer/IRAC [3.6]-[4.5] broad-band color driven by high equivalent width [OIII]+Hbeta line emission. The Lyalpha line is reliably detected at 6.1 sigma and shows an asymmetric profile as expected for a galaxy embedded in a relatively neutral inter-galactic medium near the Planck peak of cosmic reionization. The line has a rest-frame equivalent width of EW0=21+-4 A and is extended with V_FWHM=360+90-70 km/s. The source is perhaps the brightest and most massive z~8 Lyman break galaxy in the full CANDELS and BoRG/HIPPIES surveys, having assembled already 10^(9.9+-0.2) M_sol of stars at only 650 Myr after the Big Bang. The spectroscopic redshift measurement sets a new redshift record for galaxies. This enables reliable constraints on the stellar mass, star-formation rate, formation epoch, as well as combined [OIII]+Hbeta line equivalent widths. The redshift confirms that the IRAC [4.5] photometry is very likely dominated by line emission with EW0(OIII+Hbeta)= 720-150+180 A. This detection thus adds to the evidence that extreme rest-frame optical emission lines are a ubiquitous feature of early galaxies promising very efficient spectroscopic follow-up in the future with infrared spectroscopy using JWST and, later, ELTs.Comment: 6 pages, 4 figures, small updates to match ApJL accepted versio

UV Luminosity Functions at redshifts z~4 to z~10: 10000 Galaxies from HST Legacy Fields

The remarkable HST datasets from the CANDELS, HUDF09, HUDF12, ERS, and BoRG/HIPPIES programs have allowed us to map out the evolution of the UV LF from z~10 to z~4. We have identified 5859, 3001, 857, 481, 217, and 6 galaxy candidates at z~4, z~5, z~6, z~7, z~8, and z~10, respectively from the ~1000 arcmin**2 area probed. The selection of z~4-8 galaxies over the five CANDELS fields allows us to assess the cosmic variance; the largest variations are apparent at z>=7. Our new LF determinations at z~4 and z~5 span a 6-mag baseline (-22.5 to -16 AB mag). These determinations agree well with previous estimates, but the larger samples and volumes probed here result in a more reliable sampling of >L* galaxies and allow us to reassess the form of the UV LFs. Our new LF results strengthen our earlier findings to 3.4 sigma significance for a steeper faint-end slope to the UV LF at z>4, with alpha evolving from alpha=-1.64+/-0.04 at z~4 to alpha=-2.06+/-0.13 at z~7 (and alpha = -2.02+/-0.23 at z~8), consistent with that expected from the evolution of the halo mass function. With our improved constraints at the bright end, we find less evolution in the characteristic luminosity M* over the redshift range z~4 to z~7; the observed evolution in the LF is now largely represented by changes in phi*. No evidence for a non-Schechter-like form to the z~4-8 LFs is found. A simple conditional LF model based on halo growth and evolution in the M/L ratio of halos ((1+z)**-1.5) provides a good representation of the observed evolution.Comment: 53 pages, 28 figures, 11 tables, accepted for publication in the Astrophysical Journa

The Bright End of the z~9 and z~10 UV Luminosity Functions using all five CANDELS Fields

The deep, wide-area (~800-900 arcmin**2) near-infrared/WFC3/IR + Spitzer/IRAC observations over the CANDELS fields have been a remarkable resource for constraining the bright end of high redshift UV luminosity functions (LFs). However, the lack of HST 1.05-micron observations over the CANDELS fields has made it difficult to identify z~9-10 sources robustly, since such data are needed to confirm the presence of an abrupt Lyman break at 1.2 microns. We report here on the successful identification of many such z~9-10 sources from a new HST program (z9-CANDELS) that targets the highest-probability z~9-10 galaxy candidates with observations at 1.05 microns, to search for a robust Lyman-break at 1.2 microns. The potential z~9-10 candidates are preselected from the full HST, Spitzer/IRAC S-CANDELS observations, and the deepest-available ground-based optical+near-infrared observations. We identified 15 credible z~9-10 galaxies over the CANDELS fields. Nine of these galaxies lie at z~9 and 5 are new identifications. Our targeted follow-up strategy has proven to be very efficient in making use of scarce HST time to secure a reliable sample of z~9-10 galaxies. Through extensive simulations, we replicate the selection process for our sample (both the preselection and follow-up) and use it to improve current estimates for the volume density of bright z~9 and z~10 galaxies. The volume densities we find are 5(-2)(+3)x and 8(-3)(+9)x lower, respectively, than found at z~8. When compared with the best-fit evolution (i.e., dlog_{10} rho(UV)/dz=-0.29+/-0.02) in the UV luminosities densities from z~8 to z~4 integrated to 0.3L*(z=3) (-20 mag), these luminosity densities are 2.6(-0.9)(+1.5)x and 2.2(-1.1)(+2.0)x lower, respectively, than the extrapolated trends. Our new results are broadly consistent with the "accelerated evolution" scenario at z>8, as seen in many theoretical models.Comment: 23 pages, 15 figures, 7 tables, updated to match the version in press, including some minor textual corrections identified at the proof stag

Temporal and Spatial Aspects of Gas Release During the 2010 Apparition of Comet 103P/Hartley-2

We report measurements of eight primary volatiles (H2O, HCN, CH4, C2H6, CH3OH, C2H2, H2CO, and NH3) and two product species (OH and NH2) in comet 103P/Hartley-2 using high dispersion infrared spectroscopy. We quantified the long- and short-term behavior of volatile release over a three-month interval that encompassed the comet's close approach to Earth, its perihelion passage, and flyby of the comet by the Deep Impact spacecraft during the EPOXI mission. We present production rates for individual species, their mixing ratios relative to water, and their spatial distributions in the coma on multiple dates. The production rates for water, ethane, HCN, and methanol vary in a manner consistent with independent measures of nucleus rotation, but mixing ratios for HCN, C2H6, & CH3OH are independent of rotational phase. Our results demonstrate that the ensemble average composition of gas released from the nucleus is well defined, and relatively constant over the three-month interval (September 18 through December 17). If individual vents vary in composition, enough diverse vents must be active simultaneously to approximate (in sum) the bulk composition of the nucleus. The released primary volatiles exhibit diverse spatial properties which favor the presence of separate polar and apolar ice phases in the nucleus, establish dust and gas release from icy clumps (and also, directly from the nucleus), and provide insights into the driver for the cyanogen (CN) polar jet. The spatial distributions of C2H6 & HCN along the near-polar jet (UT 19.5 October) and nearly orthogonal to it (UT 22.5 October) are discussed relative to the origin of CN. The ortho-para ratio (OPR) of water was 2.85 \pm 0.20; the lower bound (2.65) defines Tspin > 32 K. These values are consistent with results returned from ISO in 1997.Comment: 18 pages, 3 figures, to be published in: Astrophysical Journal Letter

An Ontology of Soil Properties and Processes

Assessing the Underworld (ATU) is a large interdisciplinary UK research project, which addresses challenges in integrated inter-asset maintenance. As assets on the surface of the ground (e.g. roads or pave- ments) and those buried under it (e.g. pipes and cables) are supported by the ground, the properties and processes of soil a ect the performance of these assets to a signi cant degree. In order to make integrated deci- sions, it is necessary to combine the knowledge and expertise in multiple areas, such as roads, soil, buried assets, sensing, etc. This requires an underpinning knowledge model, in the form of an ontology. Within this context, we present a new ontology for describing soil properties (e.g. soil strength) and processes (e.g. soil compaction), as well as how they a ect each other. This ontology can be used to express how the ground a ects and is a ected by assets buried under the ground or on the ground surface. The ontology is written in OWL 2 and openly available from the University of Leeds data repository: http://doi.org/10.5518/54