Efeito do aldicarbe e do metamidofós na taxa de desenvolvimento de Chrysomya Albiceps, Cochliomyia Macellaria e intervalo Post-mortem.

La presente investigación tuvo como objetivo determinar la relación de la gestión académica y el desempeño docente con la percepción de satisfacción de los estudiantes de medicina de una universidad peruana, 2020. Dicho estudio empleó la metodología de tipo básica, con un método de tipo hipotético – deductivo, con enfoque cuantitativo, de diseño no experimental de nivel correlacional, transaccional. La población estuvo constituida por 250 estudiantes de la facultad de medicina de una universidad peruana y con respecto a la muestra, esta fue obtenida mediante el muestreo no probabilístico seleccionado a conveniencia del investigador y estaba constituida por 125 estudiantes de tercer, cuarto y quinto año de estudios. La técnica empleada para la recolección de datos fue la encuesta, mediante la aplicación de instrumentos estandarizados de escala de Likert para medir el nivel de la gestión académica, el desempeño docente y la percepción de satisfacción de los estudiantes respectivamente. Los resultados encontrados permitieron concluir que existe una relación significativa entre la gestión académica y el desempeño docente con la percepción de satisfacción de los estudiantes de medicina de una universidad peruana, 2020 (Sig.= 0,000 < 0,05) y que además el grado de relación entre la gestión académica con la satisfacción de los estudiantes es buena y positiva con un coeficiente Rho de Spearman = 0,633, y el grado de relación entre el desempeño docente y la satisfacción de los estudiantes es positiva e intensa con un coeficiente Rho de Spearman = 0,817.Tesi

Microplastics and Their Effect in Horticultural Crops: Food Safety and Plant Stress

The presence of micro and nanoplastics in the food chain constitutes an emergent multifactorial food safety and physiological stress problem, which must be approached with a strategic perspective since it affects public health when consuming products that have this pollutant, such as fish and crustaceans, fruits, and vegetables. In this review, the authors present the results by scientists from different disciplines who are dedicated to discovering their chemical constitution and origin, the contents of these microparticles in edible plants, the contamination of water-irrigated soils, the mechanisms that concentrate microplastics in these soils, methods to determine them, contamination of freshwater sources of cities, and the negative effect of nano and microplastics on various food products and their detrimental impact on the environment. Recent findings of plant uptake mechanisms complement this, but more research is needed

The impact of head and neck radiotherapy on the dentine-enamel junction : a systematic review

Radiotherapy is widely used in contemporary head and neck cancer treatment protocols. The ability of head and neck radiotherapy (HNRT) to cause direct radiogenic destruction to the teeth is one of the most controversial topics in the field of oral oncology. Therefore, this systematic review aimed to investigate ionising radiation as an independent factor for physical and chemical changes on the dentine-enamel junction (DEJ), a pivotal dental topography for the onset and progression of radiation-related caries (RRC) and enamel delamination. Systematic searches were conducted on three databases: Scopus, MEDLINE (Via PubMed) and Embase (Elsevier). Laboratory studies evaluating the effects of simulated or in vivo HNRT on the DEJ were included. The GRADE tool adapted for in vitro studies was used to assess the methodological quality. Of the 154 initially selected studies, eight met the inclusion criteria, from which five studies were graded as high quality of evidence, two studies were graded as moderate quality and one as low quality. Two studies did not demonstrate DEJ alterations following HNRT while the other six articles described several organic and inorganic changes in the DEJ of irradiated teeth samples. These radiogenic events were mostly detected through micro and nanoindentation, Raman micro-spectroscopy, confocal microscopy, Western blotting and optical coherence tomography. HNRT may have a negative impact on the physical and chemical aspects of the DEJ, predisposing cancer patients to RRC and enamel delamination

Eventos adversos posteriores a la vacunación contra COVID-19: un estudio de corte transversal

Los datos disponibles de farmacovigilancia de las vacunas contra la COVID-19 en Latinoamérica son limitados. El objetivo de este estudio fue determinar la frecuencia de los eventos adversos posteriores a la vacunación (EAPV) con la primera y la segunda dosis contra la COVID-19 en estudiantes de medicina de Cali (Colombia), en el 2021. Se realizó un estudio observacional descriptivo de corte transversal en adultos voluntarios que habían recibido al menos una dosis de la vacuna BNT162b2 de Pfizer-BioNTech, y que respondieron una encuesta electrónica. De los invitados, 292 adultos con una mediana de edad de 21 años (RIC: 20-22) aceptaron participar. El 95% de ellos recibió dos dosis y el 5% una dosis, el 64,4% eran mujeres y el 76,37% reportó al menos un EAPV, todos de severidad leve. El dolor en el sitio de inyección, con un 73,6%, fue el evento más reportado. Lo siguieron EAPV sistémicos como fatiga, sueño y cefalea, con el 56,8%, 46,9% y 38,6%, respectivamente, los cuales se presentaron en mayor proporción después de la segunda dosis. Con significancia estadística, las mujeres presentaron una odds ratio de exposición mayor para dolor en el sitio de inyección y escalofríos con (OR = 1,89; IC 95%: 1,07-3,33; p = 0,01) y (OR = 3,03; IC 95%: 1,63-5,88; p = 0,0002), respectivamente, en comparación con los hombres. Otras condiciones clínicas y demográficas evaluadas no tuvieron asociación significativa con el desarrollo de eventos. Por lo tanto, en esta población, al menos un EAPV se presentó en tres de cada cuatro vacunados con BNT162b2; el dolor en el sitio de inyección, la fatiga, el sueño y el dolor de cabeza, fueron los más frecuentes. Las mujeres presentaron EAPV con más frecuencia y los EAPV sistémicos se presentaron en mayor proporción para ambos sexos tras la segunda dosis. No obstante, todos los EAPV reportados fueron leves y de corta duración

Alterations in ALK/ROS1/NTRK/MET drive a group of infantile hemispheric gliomas

© The Author(s) 2019. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.Infant gliomas have paradoxical clinical behavior compared to those in children and adults: low-grade tumors have a higher mortality rate, while high-grade tumors have a better outcome. However, we have little understanding of their biology and therefore cannot explain this behavior nor what constitutes optimal clinical management. Here we report a comprehensive genetic analysis of an international cohort of clinically annotated infant gliomas, revealing 3 clinical subgroups. Group 1 tumors arise in the cerebral hemispheres and harbor alterations in the receptor tyrosine kinases ALK, ROS1, NTRK and MET. These are typically single-events and confer an intermediate outcome. Groups 2 and 3 gliomas harbor RAS/MAPK pathway mutations and arise in the hemispheres and midline, respectively. Group 2 tumors have excellent long-term survival, while group 3 tumors progress rapidly and do not respond well to chemoradiation. We conclude that infant gliomas comprise 3 subgroups, justifying the need for specialized therapeutic strategies.info:eu-repo/semantics/publishedVersio

Marco activo de recursos de innovación docente: Madrid

Una guía de espacios e instituciones para actividades educativas complementarias en enseñanza secundaria y Formación Profesional

Latin-American consensus on chronic constipation

El Consenso Latinoamericano de Estreñimiento Crónico se realizó con el objeto de proveer guías para mejorar la identificación, el diagnóstico y el tratamiento de este trastorno en la región. Dos coordinadores, y uno honorario, establecieron las líneas de consenso, basado en una revisión sistemática de la literatura médica de los últimos 10 años a partir de 1995. Participaron 17 miembros con el aval de sus respectivas sociedades locales de gastroenterología. Éstos revisaron y presentaron los temas con sus niveles de evidencia y grados de recomendación para discutirlos en una reunión plenaria. Tras un informe final de los miembros, los coordinadores prepararon las declaraciones finales para someterlas a votación en octubre de 2006. El consenso concluyó que el estreñimiento crónico tiene una prevalencia estimada del 5-21% en la región, con una relación mujer: varón de 3:1. El 75% de los sujetos que lo presenta utiliza algún tipo de medicamentos y más del 50% usa medicamentos caseros. Se recomendó un diagnóstico basado en los Criterios de Roma y los estudios diagnósticos sólo en pacientes mayores de 50 años o con algún signo de alarma. El uso de enema de colon se recomendó como investigación inicial en países con elevada frecuencia de megacolon idiopático y/o enfermedad de Chagas. En cuanto al tratamiento, se recomendó incrementar la fibra en la dieta a 25-30 g/día (grado C) y no se encontraron evidencias para ciertas medidas, como el ejercicio, el aumento de la ingesta de agua o las visitas programadas al excusado. El Psyllium recibió recomendación grado B y tratamientos farmacológicos, como tegaserod y polietilenglicol grado A. No se encontraron suficientes evidencias para recomendar la administración de lactulosa, pero no se desaprobó su uso cuando fuera necesario. Los estudios complementarios, como el tránsito colónico seguido de manometría anorrectal y defecografía, sólo se recomendaron para descartar la inercia colónica y/o la obstrucción funcional en pacientes que no respondieran al tratamiento. La biorretroalimentación se recomendó (grado B) en la disinergia del suelo pélvico.Q459-74The Latin-American Consensus on Chronic Constipation aimed to establish guidelines to improve the identification, diagnosis and treatment of this disorder in the region. Two coordinators and an honorary coordinator established the process and the topics to be discussed, based on a systematic review of the literature published in the previous 10 years, since 1995. Seventeen members participated with the support of their local gastroenterology societies. The members reviewed the different subjects based on the levels of evidence and grades of recommendation; the topics were then discussed in a plenary session. A written report was drafted and the coordinators prepared the final declarations to be submitted to a vote by all the members in October 2006. The consensus concluded that chronic constipation has an estimated prevalence of 5-21% in the region, with a female-to-male ratio of 3:1. Among individuals with constipation, 75% use some type of medication, with more than 50% using home remedies. A diagnosis based on Rome Criteria was recommended and diagnostic testing only in persons older than 50 years or with alarm symptoms. The use of barium enema as an initial investigation was recommended only in countries with a high prevalence of idiopathic megacolon or Chagas’ disease. Recommendations on treatment included an increase in dietary fiber of up to 25-30 g/day (grade C). No evidence was found to recommend measures such as exercise, increased water intake, or frequent visits to the toilet. Fiber supplements such as Psyllium received a grade B and pharmacological treatments such as tegaserod and polyethylene glycol, both grade A. There was insufficient evidence to recommend lactulose, but the consensus did not disadvise its use when necessary. Complementary investigations such as colonic transit followed by anorectal manometry and defecography were only recommended to rule out colonic inertia and/or obstructive defecation in patients not responding to treatment. Biofeedback was recommended (grade B) for those with pelvic dyssynergi

Margarita de Sossa, Sixteenth-Century Puebla de los Ángeles, New Spain (Mexico)

Margarita de Sossa’s freedom journey was defiant and entrepreneurial. In her early twenties, still enslaved in Portugal, she took possession of her body; after refusing to endure her owner’s sexual demands, he sold her, and she was transported to Mexico. There, she purchased her freedom with money earned as a healer and then conducted an enviable business as an innkeeper. Sossa’s biography provides striking insights into how she conceptualized freedom in terms that included – but was not limited to – legal manumission. Her transatlantic biography offers a rare insight into the life of a free black woman (and former slave) in late sixteenth-century Puebla, who sought to establish various degrees of freedom for herself. Whether she was refusing to acquiesce to an abusive owner, embracing entrepreneurship, marrying, purchasing her own slave property, or later using the courts to petition for divorce. Sossa continued to advocate on her own behalf. Her biography shows that obtaining legal manumission was not always equivalent to independence and autonomy, particularly if married to an abusive husband, or if financial successes inspired the envy of neighbors

The Fourteenth Data Release of the Sloan Digital Sky Survey: First Spectroscopic Data from the Extended Baryon Oscillation Spectroscopic Survey and from the Second Phase of the Apache Point Observatory Galactic Evolution Experiment

The fourth generation of the Sloan Digital Sky Survey (SDSS-IV) has been in operation since 2014 July. This paper describes the second data release from this phase, and the 14th from SDSS overall (making this Data Release Fourteen or DR14). This release makes the data taken by SDSS-IV in its first two years of operation (2014–2016 July) public. Like all previous SDSS releases, DR14 is cumulative, including the most recent reductions and calibrations of all data taken by SDSS since the first phase began operations in 2000. New in DR14 is the first public release of data from the extended Baryon Oscillation Spectroscopic Survey; the first data from the second phase of the Apache Point Observatory (APO) Galactic Evolution Experiment (APOGEE-2), including stellar parameter estimates from an innovative data-driven machine-learning algorithm known as "The Cannon"; and almost twice as many data cubes from the Mapping Nearby Galaxies at APO (MaNGA) survey as were in the previous release (N = 2812 in total). This paper describes the location and format of the publicly available data from the SDSS-IV surveys. We provide references to the important technical papers describing how these data have been taken (both targeting and observation details) and processed for scientific use. The SDSS web site (www.sdss.org) has been updated for this release and provides links to data downloads, as well as tutorials and examples of data use. SDSS-IV is planning to continue to collect astronomical data until 2020 and will be followed by SDSS-V