Infants of Depressed Mothers Living in Poverty: Opportunities to Identify and Serve

Examines the prevalence of depression among mothers in poverty by race/ethnicity, age, family structure, prenatal care and feeding practices, and factors such as domestic violence. Explores intervention points and policy initiatives for support services

Kids' Share 2008: How Children Fare in the Federal Budget

Provides an annual analysis of trends in federal spending and tax expenditures on children's programs -- such as food stamps, tax credits, and Head Start -- and assesses the impact of future budget planning on children

Kids' Share 2010: Report on Federal Expenditures on Children

Examines 1960-2009 trends in federal spending and tax expenditures on children, including food stamps, tax credits, and Head Start. Analyzes the effects of American Recovery and Reinvestment Act funding, projected funding through 2020, and implications

Public Investment in Children's Early and Elementary Years (Birth to Age 11)

Compares federal and state/local per-capita spending; funding areas such as health, education, and income support; and degree of targeting and means testing for different age groups. Discusses policy implications and the need to invest in early childhood

Kids' Share: An Analysis of Federal Expenditures on Children Through 2008

Examines 2008 data and historic trends in federal spending and tax expenditures on children -- such as food stamps, tax credits, and Head Start -- compared with other priorities and within the children's share. Assesses projections through 2019

Federal Expenditures on Elementary-Age Children in 2008 (Ages 6 through 11)

Examines 2008 federal expenditures on elementary-age children, where funds are spent, and how; estimates 2009-12 expenditures; and outlines policy issues affecting this age group, including the importance of high-quality education and obesity prevention

Federal Expenditures on Pre-Kindergarteners and Kindergarteners in 2008 (Ages 3 through 5)

Examines 2008 federal, state, and local expenditures on benefits for children ages 3 to 5. Outlines the importance of high-quality care, education, and social services during pre-K and kindergarten years to developmental, economic, and health outcomes

MRI radiomic features are independently associated with overall survival in soft tissue sarcoma

Purpose: Soft tissue sarcomas (STS) represent a heterogeneous group of diseases, and selection of individualized treatments remains a challenge. The goal of this study was to determine whether radiomic features extracted from magnetic resonance (MR) images are independently associated with overall survival (OS) in STS. Methods and Materials: This study analyzed 2 independent cohorts of adult patients with stage II-III STS treated at center 1 (N = 165) and center 2 (N = 61). Thirty radiomic features were extracted from pretreatment T1-weighted contrast-enhanced MR images. Prognostic models for OS were derived on the center 1 cohort and validated on the center 2 cohort. Clinical-only (C), radiomics-only (R), and clinical and radiomics (C+R) penalized Cox models were constructed. Model performance was assessed using Harrell\u27s concordance index. Results: In the R model, tumor volume (hazard ratio [HR], 1.5) and 4 texture features (HR, 1.1-1.5) were selected. In the C+R model, both age (HR, 1.4) and grade (HR, 1.7) were selected along with 5 radiomic features. The adjusted c-indices of the 3 models ranged from 0.68 (C) to 0.74 (C+R) in the derivation cohort and 0.68 (R) to 0.78 (C+R) in the validation cohort. The radiomic features were independently associated with OS in the validation cohort after accounting for age and grade (HR, 2.4; Conclusions: This study found that radiomic features extracted from MR images are independently associated with OS when accounting for age and tumor grade. The overall predictive performance of 3-year OS using a model based on clinical and radiomic features was replicated in an independent cohort. Optimal models using clinical and radiomic features could improve personalized selection of therapy in patients with STS

Magnetic Resonance

Contains research objectives and reports on three research projects

Is classical reality completely deterministic?

The concept of determinism for a classical system is interpreted as the requirement that the solution to the Cauchy problem for the equations of motion governing this system be unique. This requirement is generally assumed to hold for all autonomous classical systems. We give counterexamples of this view. Our analysis of classical electrodynamics in a world with one temporal and one spatial dimension shows that the solution to the Cauchy problem with the initial conditions of a particular type is not unique. Therefore, random behavior of closed classical systems is indeed possible. This finding provides a qualitative explanation of how classical strings can split. We propose a modified path integral formulation of classical mechanics to include indeterministic systems.Comment: Replace the paper with a revised versio