Response to Shayah and Coatesworth

Full assessment of snoring should involve general and local factors which contribute to the patient's complaint, such as any history of apnoea attacks, high body mass index, reflux, smoking, alcohol consumption, uvulasize and laxity of soft palate, collar size and base of tongue. The paper did not clearly identify the potential importance of these factors

Non-equivalence of key positively charged residues of the free fatty acid 2 receptor in the recognition and function of agonist versus antagonist ligands

Short chain fatty acids (SCFAs) are produced in the gut by bacterial fermentation of poorly digested carbohydrates. A key mediator of their actions is the G protein-coupled Free Fatty Acid 2 (FFA2) receptor and this has been suggested as a therapeutic target for the treatment of both metabolic and inflammatory diseases. However, a lack of understanding of the molecular determinants dictating how ligands bind to this receptor has hindered development. We have developed a novel radiolabelled FFA2 antagonist in order to probe ligand binding to FFA2 and in combination with mutagenesis and molecular modelling studies define how agonist and antagonist ligands interact with the receptor. Although both agonist and antagonist ligands contain negatively charged carboxylates that interact with two key positively charged arginine residues in transmembrane domains V and VII of FFA2, there are clear differences in how these interactions occur. Specifically, while agonists require interaction with both arginine residues to bind the receptor, antagonists require an interaction with only one of the two. Moreover, different chemical series of antagonist interact preferentially with different arginine residues. A homology model capable of rationalizing these observations was developed and provides a tool that will be invaluable for identifying improved FFA2 agonists and antagonists to further define function and therapeutic opportunities of this receptor

Decoherence suppression via environment preparation

To protect a quantum system from decoherence due to interaction with its environment, we investigate the existence of initial states of the environment allowing for decoherence-free evolution of the system. For models in which a two-state system interacts with a dynamical environment, we prove that such states exist if and only if the interaction and self-evolution Hamiltonians share an eigenstate. If decoherence by state preparation is not possible, we show that initial states minimizing decoherence result from a delicate compromise between the environment and interaction dynamics.Comment: 4 pages, 2 figure

Nash Codes for Noisy Channels

This paper studies the stability of communication protocols that deal with transmission errors. We consider a coordination game between an informed sender and an uninformed decision maker, the receiver, who communicate over a noisy channel. The sender's strategy, called a code, maps states of nature to signals. The receiver's best response is to decode the received channel output as the state with highest expected receiver payoff. Given this decoding, an equilibrium or "Nash code" results if the sender encodes every state as prescribed. We show two theorems that give sufficient conditions for Nash codes. First, a receiver-optimal code defines a Nash code. A second, more surprising observation holds for communication over a binary channel which is used independently a number of times, a basic model of information transmission: Under a minimal "monotonicity" requirement for breaking ties when decoding, which holds generically, EVERY code is a Nash code.Comment: More general main Theorem 6.5 with better proof. New examples and introductio

Focus Group. TRIADS experiences and developments. A panel discussion.

The Tripartite Interactive Assessment Delivery System (TRIADS) is an advanced computer-based assessment system designed to provide the widest possible flexibility in assessment design and delivery. Initially developed at the University of Derby it was evaluated in some forty-five departments at twenty-seven UK universities in twenty-four disciplines as part of the HEFCE-FDTL ‘Assessment of Learning Outcomes’ project (Liverpool, Derby and Open Universities 1996-2001). In the three papers that follow, the outcomes of this evaluation are summarized together with subsequent developments and examples of applications of TRIADS at Cardiff Dental School and Birkbeck College, University of London

Cyclotron Resonance in the Layered Perovskite Superconductor Sr2RuO4

We have measured the cyclotron masses in Sr2RuO4 through the observation of periodic-orbit-resonances - a magnetic resonance technique closely related to cyclotron resonance. We obtain values for the alpha, beta and gamma Fermi surfaces of (4.33+/-0.05)me, (5.81+/-0.03)me and (9.71+/-0.11)me respectively. The appreciable differences between these results and those obtained from de Haas- van Alphen measurements are attributable to strong electron-electron interactions in this system. Our findings appear to be consistent with predictions for a strongly interacting Fermi liquid; indeed, semi-quantitative agreement is obtained for the electron pockets beta and gamma.Comment: 4 pages + 3 figure

Jacobi structures revisited

Jacobi algebroids, that is graded Lie brackets on the Grassmann algebra associated with a vector bundle which satisfy a property similar to that of the Jacobi brackets, are introduced. They turn out to be equivalent to generalized Lie algebroids in the sense of Iglesias and Marrero and can be viewed also as odd Jacobi brackets on the supermanifolds associated with the vector bundles. Jacobi bialgebroids are defined in the same manner. A lifting procedure of elements of this Grassmann algebra to multivector fields on the total space of the vector bundle which preserves the corresponding brackets is developed. This gives the possibility of associating canonically a Lie algebroid with any local Lie algebra in the sense of Kirillov.Comment: 20 page

Classical field theory on Lie algebroids: Variational aspects

The variational formalism for classical field theories is extended to the setting of Lie algebroids. Given a Lagrangian function we study the problem of finding critical points of the action functional when we restrict the fields to be morphisms of Lie algebroids. In addition to the standard case, our formalism includes as particular examples the case of systems with symmetry (covariant Euler-Poincare and Lagrange Poincare cases), Sigma models or Chern-Simons theories.Comment: Talk deliverd at the 9th International Conference on Differential Geometry and its Applications, Prague, September 2004. References adde

Vortex lattice structures of Sr2_2RuO4_4

The vortex lattice structures of Sr$_2$RuO$_4$ for the odd parity representations of the superconducting state are examined for the magnetic field along the crystallographic directions. Particular emphasis is placed upon the two dimensional representation which is believed to be relevant to this material. It is shown that when the zero-field state breaks time reversal symmetry, there must exist two superconducting transitions when there is a finite field along a high symmetry direction in the basal plane. Also it is shown that a square vortex lattice is expected when the field is along the $c$-axis. The orientation of the square lattice with respect to the underlying ionic lattice yields information as to which Ru 4d orbitals are relevant to the superconducting state.Comment: 5 pages, 2 figure