11,590 research outputs found
Towards gravitationally assisted negative refraction of light by vacuum
Propagation of electromagnetic plane waves in some directions in
gravitationally affected vacuum over limited ranges of spacetime can be such
that the phase velocity vector casts a negative projection on the time-averaged
Poynting vector. This conclusion suggests, inter alia, gravitationally assisted
negative refraction by vacuum.Comment: 6 page
Breathers in the weakly coupled topological discrete sine-Gordon system
Existence of breather (spatially localized, time periodic, oscillatory)
solutions of the topological discrete sine-Gordon (TDSG) system, in the regime
of weak coupling, is proved. The novelty of this result is that, unlike the
systems previously considered in studies of discrete breathers, the TDSG system
does not decouple into independent oscillator units in the weak coupling limit.
The results of a systematic numerical study of these breathers are presented,
including breather initial profiles and a portrait of their domain of existence
in the frequency-coupling parameter space. It is found that the breathers are
uniformly qualitatively different from those found in conventional spatially
discrete systems.Comment: 19 pages, 4 figures. Section 4 (numerical analysis) completely
rewritte
Community Detection as an Inference Problem
We express community detection as an inference problem of determining the
most likely arrangement of communities. We then apply belief propagation and
mean-field theory to this problem, and show that this leads to fast, accurate
algorithms for community detection.Comment: 4 pages, 2 figure
Very small deletions within the NESP55 gene in pseudohypoparathyroidism type 1b
Pseudohypoparathyroidism (PHP) is caused by reduced expression of genes within the GNAS cluster, resulting in parathormone resistance. The cluster contains multiple imprinted transcripts, including the stimulatory G protein α subunit (Gs-α) and NESP55 transcript preferentially expressed from the maternal allele, and the paternally expressed XLas, A/B and antisense transcripts. PHP1b can be caused by loss of imprinting affecting GNAS A/B alone (associated with STX16 deletion), or the entire GNAS cluster (associated with deletions of NESP55 in a minority of cases). We performed targeted genomic next-generation sequencing (NGS) of the GNAS cluster to seek variants and indels underlying PHP1b. Seven patients were sequenced by hybridisation-based capture and fourteen more by long-range PCR and transposon-mediated insertion and sequencing. A bioinformatic pipeline was developed for variant and indel detection. In one family with two affected siblings, and in a second family with a single affected individual, we detected maternally inherited deletions of 40 and 33 bp, respectively, within the deletion previously reported in rare families with PHP1b. All three affected individuals presented with atypically severe PHP1b; interestingly, the unaffected mother in one family had the detected deletion on her maternally inherited allele. Targeted NGS can reveal sequence changes undetectable by current diagnostic methods. Identification of genetic mutations underlying epigenetic changes can facilitate accurate diagnosis and counselling, and potentially highlight genetic elements critical for normal imprint settin
Justification of the coupled-mode approximation for a nonlinear elliptic problem with a periodic potential
Coupled-mode systems are used in physical literature to simplify the
nonlinear Maxwell and Gross-Pitaevskii equations with a small periodic
potential and to approximate localized solutions called gap solitons by
analytical expressions involving hyperbolic functions. We justify the use of
the one-dimensional stationary coupled-mode system for a relevant elliptic
problem by employing the method of Lyapunov--Schmidt reductions in Fourier
space. In particular, existence of periodic/anti-periodic and decaying
solutions is proved and the error terms are controlled in suitable norms. The
use of multi-dimensional stationary coupled-mode systems is justified for
analysis of bifurcations of periodic/anti-periodic solutions in a small
multi-dimensional periodic potential.Comment: 18 pages, no figure
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