Possibilities of surgical correction of vocal cord palsy after thyroid gland operations

  Wstęp: Powikłania po zabiegach chirurgicznych gruczołu tarczowego są stale najczęstszą przyczyną obustronnego porażenia fałdów głosowych, a zaburzenia oddychania są głównym problemem w tych sytuacjach. Istnieje wiele procedur operacyjnych poszerzenia szpary głośni w przypadku obustronnego porażenia fałdów głosowych. Celem pracy była prezentacja możliwości poszerzenia szpary głośni, ocena wykonywanych technik operacyjnych oraz wyników leczenia w przypadku porażeń fałdów głosowych po zabiegach operacyjnych tarczycy. Materiał i metody: W badaniu oceniono pięć technik operacyjnych: laserowa tylna chordektomia według Denisa i Kashimy, laserowa obustronna arytenoidektomia przyśrodkowa według Crumlaya, laserowa tylna wentrykulo-chordektomia według Pia, laserowa całkowita arytenoidektomia z chordektomią tylną według Ossoffa oraz laterofiksacja według Lichtenbergera. Subiektywnej oceny poprawy wentylacyjnej dokonywano przy użyciu skali VAS. Wyniki: W latach 1998–2014 autorzy zoperowali 270 pacjentów z obustronnym porażeniem fałdów głosowych, z czego 255 (94,4%) przypadków jatrogennych po operacjach tarczycy, a 15 (7,6%) z innych przyczyn. U znacznej większości pacjentów — 77,6%, zastosowano laserową całkowitą arytenoidektomię z chordektomią tylną, a u 13,7% laterofiksację metodą Lichtenbergera. Zabieg operacyjny według Ossoffa pozwala na osiągnięcie dobrych wyników wentylacyjnych: udana dekaniulacja (62,9% po pierwszym zabiegu, 97,6% jako ostateczny odsetek) oraz znaczna lub istotna stopnia subiektywna poprawa wydolności oddechowej u 96% pacjentów. Wnioski: Arytenoidektomia według Ossoffa jest bezpieczną procedurą dającą zadowalające wyniki wentylacyjne. Pacjenci relacjonują satysfakcjonującą jakość życia oraz możliwość powrotu do życia zawodowego. Zdaniem autorów pracy, laterofiksacja powinna pozostać jako alternatywa dla czasowej tracheotomii raczej niż zabieg zasadniczy. (Endokrynol Pol 2015; 66 (5): 412–416)    Introduction: Surgery of the thyroid gland remains the main cause of bilateral vocal cord palsy (VCP). Ventilation problem is the main problem in such situations. There are a couple of corrective surgical procedures in the case of VCP. The aim of our study was to show the possibility of widening of the glottis, and to evaluate the techniques and effects of surgical treatments due to bilateral VCP resulting from thyroid gland surgery. Material and methods: Five methods of surgical treatment were used: laser-assisted posterior cordectomy, according to Denis and Kashima; laser-assisted bilateral medial arytenoidectomy, as proposed by Crumley; laser-assisted posterior ventriculocordectomy, as described by Pia; laser-assisted total arytenoidectomy with posterior cordectomy, as presented by Ossoff; and laterofixation, according to Lichtenberger. The postoperative patient’s subjective improvement was assessed using visual analogue scale. Results: Between 1998 and 2014 we operated on 270 patients with bilateral VCP. Paresis occurred as the result of the iatrogenic effect of thyroid gland surgery in 255 patients (94.4%) vs. 15 (7.6%) from other causes. The majority of our patients (77.6%) had undergone laser arytenoidectomy with posterior partial cordectomy, and in 13.7% of them Lichtenberger laterofixation had been performed. Ossoff ’s surgery gives good ventilation results: successful decannulation (62.9% after first surgery; 97.6% final rate) and significant subjective ventilation improvement in 96% of patients. Conclusions: Ossoff ’s laser arytenoidectomy with posterior cordectomy is a safe procedure that gives acceptable ventilation improvement. Patients report satisfactory quality of life and the possibility of returning to active professional life. Laterofixation should be considered as an alternative for tracheotomy rather than permanent procedure. (Endokrynol Pol 2015; 66 (5): 412–416)

Relationship between vitamin D status and the inflammatory state in patients with chronic spontaneous urticaria

BACKGROUND: Chronic spontaneous urticaria (CSU) is an immune-inflammatory disease, characterized by acute phase response (APR) and immune activation. There has been increasing evidence showing that vitamin D deficiency/insufficiency is associated with increased incidence and/or severity of immune-inflammatory disorders. AIM: To assess relationship between vitamin D status and C-reactive protein (CRP), a nonspecific inflammatory marker of CSU activity. METHODS: Concentrations of CRP and 25-hydroxyvitamin D [25(OH)D], a biomarker of vitamin D status were measured in serum of CSU patients and compared with the healthy controls. RESULTS: Serum 25(OH)D concentration was significantly lower in CSU group as compared with the normal subjects. The prevalence of vitamin D deficiency (< 20 ng/ml) was significantly higher in patients with CSU than among normal population. There were no significant differences in prevalence of 25(OH)D insufficiency between the groups. Serum CRP concentrations were significantly higher in CSU patients as compared with the healthy subjects. There were no significant correlations between CRP and 25(OH)D concentrations in CSU patients. CONCLUSIONS: CSU is associated with lower serum 25(OH)D concentration and higher prevalence of its deficiency. The results failed to show any effect of vitamin D status on circulating CRP concentrations in CSU. A potential role of vitamin D in pathogenesis and/or additive therapy of CSU needs to be examined in other cohorts of CSU patients as well as in larger studies

Oxidative Stress Markers Patients with Parotid Gland Tumors: A Pilot Study

Salivary gland tumors account for 3–6% of tumors of the head and neck. About 80% of salivary gland tumors occur in parotid glands. Oxidative stress (OS) is implicated in the origin, development, and whole-body effects of various tumors. There are no data on the occurrence of OS in the parotid gland tumors. The aim of this study was to ascertain if whole-body OS accompanies parotid gland tumors, based first of all on oxidative modifications of blood serum proteins and other markers of OS in the serum of the patients. The group studied included 17 patients with pleomorphic adenoma, 9 patients with Warthin’s tumor, 8 patients with acinic cell carcinoma, and 24 age-matched controls. We found increased concentration of interleukin 4 in patients with acinic cell carcinoma, decreased plasma thiols, increased AOPP concentration, and decreased FRAP of blood serum in all groups of the patients while protein oxidative modifications assessed fluorimetrically, protein carbonyls, protein nitration, malondialdehyde concentration, and serum ABTS⁎-scavenging capacity were unchanged. These data indicate the occurrence of OS in patients with parotid gland tumors and point to various sensitivities of OS markers