Changes In The Development Process Of Mobile Phone Applications Bring Opportunities For Developers And More Options To Consumers

Consumers are becoming increasingly comfortable with technology.  As their knowledge and use of technology has increased, so too have their expectations and roles in the technology environment. New technology brings about new products, and the process of developing new products is ongoing.  Research and development, turnaround times, product introduction timing, and development efforts of the competition all influence the process. The race to move new technology to the market as quickly as possible has significantly changed the development process.  Individuals now have development opportunities that generally belonged to corporations years ago.  As Smartphones become more mainstream, the race to create applications (apps) for the devices has presented entrepreneurial opportunities for companies and individuals alike. Not only is the demand for apps increasing, but the power of apps is also increasing.  Apps have the ability to affect consumer demands and, ultimately, impact what is available in the marketplace

Consolidation And Changing Consumer Preferences Impact The Structure And Future Of The Publishing Industry

The publishing industry has experienced several changes that have had a major impact on its business. There has been considerable consolidation of the publishing houses, significant technological changes, and a shift in consumer opinions regarding textbooks. This has put a strain on the publishers’ supply chain, as well as their ability to compete in the marketplace. The cannibalization of sales within a publisher’s product mix has led to even more strain in extending product life cycles. The combination of students questioning the value of textbooks combined with decreasing profit margins has left many publishers struggling to survive

End-user development for smart environments (EUD4SE)

Preface

Asparagine bioavailability governs metastasis in a model of breast cancer.

Using a functional model of breast cancer heterogeneity, we previously showed that clonal sub-populations proficient at generating circulating tumour cells were not all equally capable of forming metastases at secondary sites. A combination of differential expression and focused in vitro and in vivo RNA interference screens revealed candidate drivers of metastasis that discriminated metastatic clones. Among these, asparagine synthetase expression in a patient's primary tumour was most strongly correlated with later metastatic relapse. Here we show that asparagine bioavailability strongly influences metastatic potential. Limiting asparagine by knockdown of asparagine synthetase, treatment with l-asparaginase, or dietary asparagine restriction reduces metastasis without affecting growth of the primary tumour, whereas increased dietary asparagine or enforced asparagine synthetase expression promotes metastatic progression. Altering asparagine availability in vitro strongly influences invasive potential, which is correlated with an effect on proteins that promote the epithelial-to-mesenchymal transition. This provides at least one potential mechanism for how the bioavailability of a single amino acid could regulate metastatic progression

Parseval-type relations for Laplace transform and their applications

In the present note, two Parseval-type relations involving the Laplace transform are given. The application of the relations is demonstrated in evaluating improper integrals and Laplace transforms of trigonometric functions

The Influence Of Roughness On A High-Pressure Steam Turbine Stage: An Experimental And Numerical Study

This work deals with the influence of roughness on highpressure steam turbine stages. It is divided in three parts. In the first one, an experimental campaign on a linear cascade is described, in which blade losses are measured for different values of surface roughness and in a range of Reynolds numbers of practical interest. The second part is devoted to the basic aspects of the numerical approach, and consists of a detailed discussion of the roughness models used for computations. The fidelity of such models is then tested against measurements, thus allowing their fine-tuning and proving their reliability. Finally, comprehensive CFD analysis is carried out on a high-pressure stage, in order to investigate the influence of roughness on the losses over the entire stage operating envelope. Unsteady effects that may affect the influence of the roughness, such as the upcoming wakes on the rotor blade, are taken into account, and the impact of transition-related aspects on the losses is discussed

Interaction of Wheelspace Coolant and Main Flow in a New Aeroderivative Low Pressure Turbine

Increased computational capabilities make available for the aero/thermal designers new powerful tools to include more geometrical details, improving the accuracy of the simulations and reducing design costs and time. In the present work, a low-pressure turbine was analyzed, modeling the rotor-stator including the wheel space region. Attention was focused on the interaction between the coolant and the main flow in order to obtain a more detailed understanding of the behavior of the angel wings, to evaluate the wall heat flux distribution, and to prevent hot gas ingestion. Issues of component reliability related to thermal stress require accurate modeling of the turbulence and unsteadiness of the flow field. To satisfy this accuracy requirement, a full 3D URANS simulation was carried out. A reduced count ratio technique was applied in order to decrease numerical simulation costs. The study was carried out to investigate a new two-stage low-pressure turbine from GE Infrastructure Oil & Gas to be coupled to a new aeroderivative gas generator (the LM2500+G4) developed by GE Infrastructure, Aviation

Paget's disease of the male breast: case report and a point of view from actual literature

Paget disease of the nipple in man is a very rare breast cancer, and there are not standard procedures or guidelines. In any cases, a Paget's disease could hide an invasive ductal breast cancer.Introduction. Paget disease of the nipple in man is a very rare breast cancer, and there are not standard procedures or guidelines. In any cases, a Paget’s disease could hide an invasive ductal breast cancer. Case description. We report the case of a 77-years old man affected by Alzheimer’s disease, who presented to our attention because of an ulcerated palpable mass in the right nipple. A biopsy of the lesion showed “intra-epidermic proliferation of epitelioid cells, associated with linfo-plasmacellular infiltration of superficial dermis, compatible with Paget’s disease (pTis)". We discussed the case in the multidisciplinary meeting and decided to subject the patient to surgery, so a right mastectomy plus sentinel lymph node biopsy (SLNB) were performed. Histo-pathological examination revealed “invasive ductal carcinoma of the breast, associated with a small component of in situ ductal carcinoma and Paget’s disease of the nipple with superficial ulceration”. Resection margins were free. Sentinel lymph node was negative. Biological features were as follows: ER 95%, PR 60%, Her-2/neu 1+, Ki-67 35%. The patient was discharged in the third post-operative day in good conditions. In the following weeks the patient’s healing process was good and free of complications. Conclusions. Clinical recognition of Paget’s disease is very important also in man, because it can be the alarm bell for an underlying invasive ductal breast cancer, often more aggressive than in woman