Ethological and experimental approaches to behavior analysis: implications for ecotoxicology.

Laboratory research in toxicology has progressed far beyond reliance on measures of mortality to make use of sophisticated behavioral preparations that can evaluate the consequences of sublethal toxicant exposure. In contrast, field studies have not evolved as rapidly. Approaches developed by experimental psychologists and ethologists provide powerful and complementary methodologies to the study of environmental pollutants and behavior. Observational data collection techniques can easily be used to broaden the number of questions addressed regarding sublethal exposure to toxic agents in both field and laboratory environments. This paper provides a background in such techniques, including construction of ethograms and observational methodologies, and the use of laboratory analogues to naturally occurring activities such as social behavior, predation, and foraging. Combining ethological and experimental approaches in behavior analysis can result in a more comprehensive evaluation of the effects of environmental contaminants on behavior

Engineered nanomaterials: exposures, hazards, and risk prevention

Nanotechnology presents the possibility of revolutionizing many aspects of our lives. People in many settings (academic, small and large industrial, and the general public in industrialized nations) are either developing or using engineered nanomaterials (ENMs) or ENM-containing products. However, our understanding of the occupational, health and safety aspects of ENMs is still in its formative stage. A survey of the literature indicates the available information is incomplete, many of the early findings have not been independently verified, and some may have been over-interpreted. This review describes ENMs briefly, their application, the ENM workforce, the major routes of human exposure, some examples of uptake and adverse effects, what little has been reported on occupational exposure assessment, and approaches to minimize exposure and health hazards. These latter approaches include engineering controls such as fume hoods and personal protective equipment. Results showing the effectiveness - or lack thereof - of some of these controls are also included. This review is presented in the context of the Risk Assessment/Risk Management framework, as a paradigm to systematically work through issues regarding human health hazards of ENMs. Examples are discussed of current knowledge of nanoscale materials for each component of the Risk Assessment/Risk Management framework. Given the notable lack of information, current recommendations to minimize exposure and hazards are largely based on common sense, knowledge by analogy to ultrafine material toxicity, and general health and safety recommendations. This review may serve as an overview for health and safety personnel, management, and ENM workers to establish and maintain a safe work environment. Small start-up companies and research institutions with limited personnel or expertise in nanotechnology health and safety issues may find this review particularly useful

Revertibility of me-1 alleles

Revertibility of me-1 allele

Believing in belief : the modernist quest for spiritual meaning (Croyer en croyance : la quête moderniste pour le sens spirituel)

[À l'origine dans / Was originally part of : Thèses et mémoires - FAS - Département d'études anglaises]Cette thèse défend l’idée que plusieurs auteurs modernistes ont utilisé des concepts centraux à la croyance religieuse traditionnelle afin de préconiser le changement social. Au lieu de soutenir l'hypothèse de la sécularisation, qui prétend que les modernistes ont rejeté la religion en faveur d'une laïcité non contestée, j'argumente en faveur de ce que j'appelle « la spiritualité moderniste, » qui décrie une continuité intégrale des concepts spirituels dans l'agitation de la période moderniste qui a déstabilisée les institutions qui avait auparavant jeté les bases de la société Occidentale. En me basant sur les écrit de Sigmund Freud, William James et Émile Durkheim concernant les fins poursuivis par la religion, je développe cinq concepts centraux de la croyance religieuse que les modernistes ont cherché à resignifier, à savoir la rédemption, la communauté, la sacralité, le spectre, et la liturgie, et, dans chaque cas, j'ai montré comment ces catégories ont été réinterprétées pour traiter des questions considérées comme essentielles au début du vingtième siècle, à savoir ce que l’on identifie aujourd’hui comme le féminisme, l'écologie, la biopolitique, les crises, et le rôle du poète. Le chapitre I se concentre sur la rédemption par le féminin telle qu’on la trouve dans le recueil de vers de H.D. portant sur la Seconde Guerre mondiale, Trilogy (1944-1946), qui projette un certain espoir grâce à un mélange synchrétique de Christianisme, de mythes anciens, d’astrologie, et de psychologie. Mon deuxième chapitre discute de The Grapes of Wrath (1939) de John Steinbeck, qui élargit le rôle de la communauté en avançant une écologie universelle qui concevoit tous les gens comme étant intimement liés entre eux et avec le monde. Le chapitre III traite de la notion du sacré dans The Light in August (1932) de Willam Faulkner et Nightwood (1936) de Djuna Barnes, qui préconisent une foi privatisée qui accentue l'illégitimité des concepts de sacralité et de pollution en élevant des individus qui sont marginalisés biopolitiquement. Le chapitre IV cherche à comprendre le retour des morts, et je soutiens que le topos a été utilisé par les modernistes comme un symbole de crises sociales; le chapitre enquête d'abord sur “The Jolly Corner” (1908) de Henry James, que j'ai lu comme la séquence rêvée d'un homme faisant face à son propre spectre, Ulysses (1922) de James Joyce, où Stephen Dedalus est hanté de façon répétée par le spectre de sa mère, et Mrs. Dalloway (1925) de Virginia Woolf, qui se concentre sur le motif caché de la Fête des Morts. Ma cinquième section traite de la liturgie, la langue poétique utilisée pour les rites religieux, dans la première poésie de Wallace Stevens, qui conçoit le rôle du poète comme une vocation de l'imagination.This dissertation argues that many modernist writers used concepts central to traditional religious belief in order to urge social change. Against the secularization hypothesis, which posits that the modernists fully jettisoned religion in favour of an unquestioned secularism, I argue for what I term “modernist spirituality,” which identifies an integral continuance of spiritual concepts within the dire turmoil of the modernist period that destabilized the institutions such as an established organized religion that had previously formed the foundations of Western society. Hence, in each of my dissertation chapters, I have looked outside of organized religion to literature to find that spiritual impulse. Building upon the purposes of religion as defined by Sigmund Freud, William James, and Émile Durkheim, I name five concepts central to religious belief that the modernists sought to resignify, namely redemption, community, sacredness, the spectre, and liturgy, and, in each case, I have shown how these categories were reinterpreted to treat issues considered vital in the early twentieth century that would now be identified under the categories of feminism, ecology, biopolitics, crisis, and the role of the poet. The first function of spiritual belief addresses the intertwining of redemption and humanity’s actions within history, and for this reason, Chapter I focuses on redemption through the feminine as seen in H.D.’s book of World War II verse, Trilogy (1944-1946), which offers hope through a syncretistic blend of Christianity, ancient myths, goddess traditions, astrology, and psychology. My second chapter discusses John Steinbeck's The Grapes of Wrath (1939), which enlarges the role of community by positing a universal ecology of holiness that sees all people as connected with one another and with the land. Chapter III treats the notion of the sacred in William Faulkner’s Light in August (1932) and Djuna Barnes’ Nightwood (1936), both of which urge a privatized faith that emphasizes the illegitimacy of concepts of sacredness and pollution by elevating individuals who are marginalized biopolitically. Chapter IV seeks to comprehend the return of the dead in dreams or in visions, and I argue that the topos was used by modernists as a symbol of social crisis; the chapter first investigates Henry James’ “The Jolly Corner” (1908), which I read as a dream sequence of a man facing his own ghost, James Joyce’s Ulysses (1922), wherein Stephen Dedalus is haunted repeatedly by the ghost of his mother, and Virginia Woolf’s Mrs. Dalloway (1925), which is textually ordered by the hidden motif of the Day of the Dead. My fifth section is an epilogue that treats liturgy, the poetic language used for religious rituals, in the early poetry of Wallace Stevens, who revisions the role of the poet as a vocation of the imagination

Metal-Based Nanoparticle Interactions with the Nervous System: The Challenge of Brain Entry and the Risk of Retention in the Organism

This review of metal-based nanoparticles focuses on factors influencing their distribution into the nervous system, evidence they enter brain parenchyma, and nervous system responses. Gold is emphasized as a model metal-based nanoparticle and for risk assessment in the companion review. The anatomy and physiology of the nervous system, basics of colloid chemistry, and environmental factors that influence what cells see are reviewed to provide background on the biological, physical–chemical, and internal milieu factors that influence nervous system nanoparticle uptake. The results of literature searches reveal little nanoparticle research included the nervous system, which about equally involved in vitro and in vivo methods, and very few human studies. The routes of uptake into the nervous system and mechanisms of nanoparticle uptake by cells are presented with examples. Brain nanoparticle uptake inversely correlates with size. The influence of shape has not been reported. Surface charge has not been clearly shown to affect flux across the blood-brain barrier. There is very little evidence for metal-based nanoparticle distribution into brain parenchyma. Metal-based nanoparticle disruption of the blood-brain barrier and adverse brain changes have been shown, and are more pronounced for spheres than rods. Study concentrations need to be put in exposure contexts. Work with dorsal root ganglion cells and brain cells in vitro show the potential for metal-based nanoparticles to produce toxicity. Interpretation of these results must consider the ability of nanoparticles to distribute across the barriers protecting the nervous system. Effects of the persistence of poorly soluble metal-based nanoparticles are of particular concern

Coastal erosion reveals a potentially unique Oligocene and possible periglacial sequence at present-day sea level in Port Davey, remote South-West Tasmania

Cut-back of a sea-cliff at Hannant Inlet in remote South-West Tasmania has exposed Oligocene clays buried under Late Pleistocene “colluvium” from which abundant wood fragments protrude. The two units are separated by a transitional interval defined by mixed Oligocene and Pleistocene microfloras. Microfloras preserved in situ in the clay provide a link between floras in Tasmania and other Southern Hemisphere landmasses following onset of major glaciation in East Antarctica during the Eocene-Oligocene transition (c. 34 Ma). The Late Pleistocene “colluvium” preserves abundant fossil pollen of the shrub conifer genus Pherosphaera (al. Microstrobos). Assuming the parent plants had the same upper subalpine-alpine ecology as living Pherosphaera hookeriana, the microflora provides evidence for cold, wet conditions in the Port Davey lowlands during a low sea-level stand. The same data highlight the failure of Pherosphaera to regain its Pleistocene distribution during the Postglacial period. Our data are inconclusive whether Late Pleistocene conditions in Hannant Inlet were periglacial, i.e., the Oligocene sediments were turbated by freeze-thaw processes, or have been reworked by fluvial processes into the Pleistocene “colluvium”. Nevertheless, the inferred cold-climate is consistent with the former hypothesis. The sequence is sealed under cross-bedded coarse quartzite gravels of presumed Last Glacial Stage age

Using the health action process approach to predict and improve health outcomesin individuals with type 2 diabetes mellitus

Background: The purpose of this study was to explore the predictive utility of the Health Action Process Approach (HAPA) and test a HAPA-based healthy eating intervention, in adults with type 2 diabetes mellitus. Materials and methods: The study employed a prospective, randomized, controlled trial design. The 4-month intervention consisted of self-guided HAPA-based workbooks in addition to two telephone calls to assist participants with the program implementation, and was compared to “treatment as usual”. Participants (n=87) completed health measures (diet, body mass index [BMI], waist circumference, blood pressure, blood glucose levels, lipid levels, and diabetes distress) and HAPA measures prior to the intervention and again upon completion 4 months later. Results: The overall HAPA model predicted BMI, although only risk awareness and recovery self-efficacy were significant independent contributors. Risk awareness, intentions, and self-efficacy were also independent predictors of health outcomes; however, the HAPA did not predict healthy eating. No significant time × condition interaction effects were found for diet or any HAPA outcome measures. Conclusion: Despite the success of HAPA in predicting health outcomes for those with type 2 diabetes mellitus, the intervention was unsuccessful in changing healthy eating or any of the other measured variables, and alternative low-cost health interventions for those with type 2 diabetes mellitus should be explored

European ancient settlements - A guide to their composition and morphology based on soil micromorphology and associated geoarchaeological techniques; introducing the contrasting sites of Chalcolithic Bordus, ani-Popina, Borcea River, Romania and Viking Age Heimdaljordet, Vestfold, Norway

Specific soil micromorphological, broader geoarchaeological and environmental archaeology signatures of settlement activities and land use have been identified from numerous case studies across Europe – from Romania to western Norway. In order to demonstrate how such investigations contribute to our understanding of settlement morphology and its wider landscape, an improved way of organising site-specific information or guide was created (Macphail and Goldberg, in press). Activities and land use are divided into ‘Within Settlement’, ‘Peripheral to Settlement’ and ‘The Settlement's Wider Landscape’. Major themes identified are: Constructions (and materials), Trackways and paths (and other communication/transport-associated features), Animal Management, Water Management, Waste Disposal (1: middening; 2: human waste), Specialist Domestic and Industrial Activities and Funerary Practices. In the case of trackway deposits, their characterisation aids the identification of intensely occupied areas compared to rural communications, although changing land use within urban areas has also produced ‘rural signatures’ (e.g. as associated with animal management), for example in Late Roman cities. Specialist activities such as fish and crop processing or working with lead and other metals, in-field and within-wall manuring, stabling and domestic occupation floor-use evidence, and identification of different funerary practice – cremations, boat graves and other inhumations, and excarnation features – and peripheral constructions such as boat-houses, are also noted. New information from the Chalcolithic tell site of Borduşani-Popină, Romania and seasonally occupied Viking settlement of Heimdaljordet, Norway, is introduced