The system of genetic exchange in <i>Trypanosoma brucei</i> and other trypanosomatids

In this chapter, we discuss our current understanding of the systems of genetic exchange in trypanosomatids and the im-pact the recent genome projects have had on this area of research. We focus mainly on the details of Trypanosoma brucei as it is the most extensively studied of the “trityps”, but will also refer to a recently discovered novel mechanism of genetic exchange in T. cruzi and the apparent rarity of genetic ex-change in Leishmania sp.The system of genetic exchange in Trypanosoma brucei has been known to exist since the late eighties when a genetic cross between different strains was carried out by co-transmission through the tsetse fly. We discuss the segregation of nuclear, chromosomal and kDNA markers and outline the two current models for the mechanism of genetic exchange. We also present how the completion of the genome project has allowed the identification of polymorphic micro and minisatel-lite markers distributed throughout the genome, which have been used to prove formally that meiosis, independent assortment and crossing over occur in this para-site, as would be predicted in a conventional Mendelian system. Such data have been used to construct the first genetic map of T. brucei, which opens up the use of genetic analysis, coupled with positional cloning and the genome sequence, as a tool to identify the genes involved in a range of traits relevant to the disease

The Ingenious Crowd�: A Critical Prosopography of British Inventors, 1650-1850

simulation, models

Emotional Education as second language acquisition?

In this paper we argue that while emotional education intervention packages offer certain advantages, there are risks associated with their uncritical use. The main risk is that if the unwanted behaviour of some pupils is seen merely as a problem that can be dealt with through targeted intervention, then important, identity constitutive parts of their reality might become obscured. We reconsider sociological explanations of school disaffection, along with more recent sociological and philosophical attempts to explore the emotional aspect of schooling. We hypothesise that some of the challenging behaviour exhibited by young people in schools is solution seeking; that it is a functional adaptation to an essentially foreign emotional environment. We conclude that attempts to educate the emotions should aim to develop morally rich virtues rather than empty intelligences

The Cohen Macaulay property for noncommutative rings

Let R be a noetherian ring which is a finite module over its centre Z(R). This paper studies the consequences for R of the hypothesis that it is a maximal Cohen Macaulay Z(R)-module. Old results are reviewed and a number of new results are proved. The additional hypothesis of homological grade symmetry is proposed as the appropriate extra lever needed to extend the classical commutative homological hierarchy to this setting, and results are given offering evidence in support of this proposal.Comment: Preliminary version; comments welcom

Inducement of heterochronic variation in a species of planktic foraminifera by a Late Eocene impact event

While it is well known that the cosmic impact event at or near the Cretaceous-Tertiary boundary coincides with an interval of mass extinction, a similar impact (or series of impacts) near the Eocene-Oligocene boundary presents a more complex picture, in terms of associated fluctuations in marine biotic diversity. Tektites, microtektites, and mineral grains exhibiting features of shock metamorphism found in Eocene sediments of the western N. Atlantic, Caribbean, and Gulf of Mexico (comprising the North American microtektite strewn field) offer compelling evidence for a catastrophic impact event. Despite the magnitude of this event, however, few extinctions in the planktic marine fauna are known to have occurred coincident with this event. Instead, changes in relative abundance, morphology, and development occurred. Cosmic impacts generally have been interpreted as influencing the course of evolution through the wholesale elimination of significant portions of standing biotic diversity. Indeed, extinction traditionally has been viewed as the negative side of evolution. In some instances, it is suggested such impact events can serve instead to increase, rather than decrease, morphological and ecological diversity, by altering the developmental programs within species at the level of the local population

Medium-term prognosis of an incident cohort of parkinsonian patients compared to controls

Funding This work was supported by Parkinson's UK (grant numbers G0502, G0914), BMA Doris Hillier Award, the BUPA Foundation, NHS Grampian Endowments, RS MacDonald Trust.Peer reviewedPublisher PD

Contracts between Legal Persons

Contract law and the economics of contract have, for the most part, developed independently of each other. In this essay, we briefly review the notion of a contract from the perspective of lawyer, and then use this framework to organize the economics literature on contract. The title, Contracts between Legal Persons, limits the review to that part of contract law that is generic to any legal person. A legal person is any individual, firm or government agency with the right to enter into binding agreements. Our goal is to discuss the role of the law in enforcing these agreements under the hypothesis that the legal persons have well defined goals and objectives.contract law, law and economics, contract breach, contract theory, incomplete contracts

A functional electrical stimulation system for human walking inspired by reflexive control principles

This study presents an innovative multichannel functional electrical stimulation gait-assist system which employs a well-established purely reflexive control algorithm, previously tested in a series of bipedal walking robots. In these robots, ground contact information was used to activate motors in the legs, generating a gait cycle similar to that of humans. Rather than developing a sophisticated closed-loop functional electrical stimulation control strategy for stepping, we have instead utilised our simple reflexive model where muscle activation is induced through transfer functions which translate sensory signals, predominantly ground contact information, into motor actions. The functionality of the functional electrical stimulation system was tested by analysis of the gait function of seven healthy volunteers during functional electrical stimulation–assisted treadmill walking compared to unassisted walking. The results demonstrated that the system was successful in synchronising muscle activation throughout the gait cycle and was able to promote functional hip and ankle movements. Overall, the study demonstrates the potential of human-inspired robotic systems in the design of assistive devices for bipedal walking

Electro-optic bunch diagnostics on ALICE

An electro-optic longitudinal bunch profile monitor has been implemented on ALICE (Accelerators and Lasers in Combined Experiments) at the Daresbury Laboratories and will be used both to characterise the electron bunch and to provide a testbed for electro-optic techniques. The electro-optic station is located immediately after the bunch compressor, within the FEL cavity; its location allows nearby OTR, beam profile monitors and Coherent Synchrontron Radiation (CSR) diagnostics to be used for calibration and benchmarking. We discuss the implementation and the planned studies on electro-optic diagnostics using this diagnostic station