22 research outputs found
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The inner Workings of a Market for Transferable Fishing Rights in the Florida Spiny Lobster Fishery
With a national policy on catch shares in progress in the United States and
increasing use of transferable fishing rights in fisheries worldwide, it is
important to understand how the markets created by these programs
function in the real world. This paper presents information collected from
interviews with Florida spiny lobster fishermen on how the market for trap
certificates works, how they make decisions to buy and sell certificates,
and their perceptions of the program. The interviews indicate that the
fishermen participate in the market in ways we expect, but may be hindered
by cultural and social differences that impede transfers; program provisions
that affect decision-making in transfers; and the emergence of brokers in
the market. The study also revealed how information about certificate
prices and availability circulates within and between fishing communities,
and how this affects the market and the outcomes of the program. When
compared to results from previous analyses of transactions data, the
interviews also provide information on validity of conclusions, and offers
alternative explanations uncovered when the fishermen themselves explain
the trap certificate market. The results of this paper suggest that
management and regulating agencies should directly address these issues
that could affect the market when developing and amending transferable
fishing rights programs. Additionally, it exemplifies the importance of
combining interviews with fishermen with economic analyses in
monitoring and evaluation in order to gain a better understanding of how
these programs work
A Randomized Study Evaluating Oral Fusidic Acid (CEM-102) in Combination With Oral Rifampin Compared With Standard-of-Care Antibiotics for Treatment of Prosthetic Joint Infections: A Newly Identified Drug–Drug Interaction
BACKGROUND: Fusidic acid (FA) has been used for decades for bone infection, including prosthetic joint infection (PJI), often in combination with rifampin (RIF). An FA/RIF pharmacokinetic interaction has not previously been described.
METHODS: In a phase 2 open-label randomized study, we evaluated oral FA/RIF vs standard-of-care (SOC) intravenous antibiotics for treatment of hip or knee PJI. Outcome assessment occurred at reimplantation (week 12) for subjects with 2-stage exchange, and after 3 or 6 months of treatment for subjects with hip or knee debride and retain strategies, respectively.
RESULTS: Fourteen subjects were randomized 1:1 to FA/RIF or SOC. Pharmacokinetic profiles were obtained for 6 subjects randomized to FA/RIF. FA concentrations were lower than anticipated in all subjects during the first week of therapy, and at weeks 4 and 6, blood levels continued to decline. By week 6, FA exposures were 40%-45% lower than expected.
CONCLUSIONS: The sponsor elected to terminate this study due to a clearly illustrated drug-drug interaction between FA and RIF, which lowered FA levels to a degree that could influence subject outcomes. Optimization of FA exposure if used in combination with RIF should be a topic of future research.
CLINICAL TRIALS REGISTRATION: NCT01756924
The fishery performance indicators: a management tool for triple bottom line outcomes
Pursuit of the triple bottom line of economic, community and ecological sustainability has increased the complexity of fishery management; fisheries assessments require new types of data and analysis to guide science-based policy in addition to traditional biological information and modeling. We introduce the Fishery Performance Indicators (FPIs), a broadly applicable and flexible tool for assessing performance in individual fisheries, and for establishing cross-sectional links between enabling conditions, management strategies and triple bottom line outcomes. Conceptually separating measures of performance, the FPIs use 68 individual outcome metrics--coded on a 1 to 5 scale based on expert assessment to facilitate application to data poor fisheries and sectors--that can be partitioned into sector-based or triple-bottom-line sustainability-based interpretative indicators. Variation among outcomes is explained with 54 similarly structured metrics of inputs, management approaches and enabling conditions. Using 61 initial fishery case studies drawn from industrial and developing countries around the world, we demonstrate the inferential importance of tracking economic and community outcomes, in addition to resource status.James L. Anderson ... Tim Ward ... et al
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The Fishery Performance Indicators: A Management Tool for Triple Bottom Line Outcomes
Pursuit of the triple bottom line of economic, community and ecological sustainability has increased the complexity of fishery management; fisheries assessments require new types of data and analysis to guide science-based policy in addition to traditional biological information and modeling. We introduce the Fishery Performance Indicators (FPIs), a broadly applicable and flexible tool for assessing performance in individual fisheries, and for establishing cross-sectional links between enabling conditions, management strategies and triple bottom line outcomes. Conceptually separating measures of performance, the FPIs use 68 individual outcome metrics—coded on a 1 to 5 scale based on expert assessment to facilitate application to data poor fisheries and sectors—that can be partitioned into sector-based or triple-bottom-line sustainability-based interpretative indicators. Variation among outcomes is explained with 54 similarly structured metrics of inputs, management approaches and enabling conditions. Using 61 initial fishery case studies drawn from industrial and developing countries around the world, we demonstrate the inferential importance of tracking economic and community outcomes, in addition to resource status