8 research outputs found
Reliability study of the Behavioral Assessment of the Dysexecutive Syndrome adapted for a Brazilian sample of older-adult controls and probable early Alzheimer's disease patients
Color Responses of Flash Visual Evoked Potentials in Normal Adults, Normal Elderly Subjects and Dementia of the Alzheimer Type Using Light Emitting Diodes
Visual cognitive function in dementia of Alzheimer's type: a comparison of visual event-related potentials and Stroop test
Flash Visual Evoked Potentials of Various Derivations in Dementia of the Alzheimer Type and Vascular Dementia
Vibrational spectroscopic analysis of peripheral blood plasma of patients with Alzheimer’s disease
Using Raman and infrared spectroscopy, we monitored spectral changes occurring in the blood plasma of patients with Alzheimer’s disease (AD) in relation to healthy controls. The protein secondary structure as reflected by amide I band involves β-sheet enrichment, which may be attributable to Aβ peptide formation and to increasing proportion of the globulins that are β-sheet rich. Likewise, the behavior of the infrared 1200–1000–cm−1 region and the Raman 980–910- and 450–400-cm−1 regions can be explained in terms of the said plasma composition change. Further, the 744-cm−1 Raman band from healthy control plasma shows frequency upshifting in the course of AD, which may be generated by the platelets collected in blood plasma. Linear discrimination analysis and receiver operating characteristic (ROC) analysis have been used to distinguish between patients with AD and age-matched healthy controls with a diagnostic accuracy of about 94 %.Ministerio de Ciencia e Innovación de EspañaMinisterio de Economía y Competitividad de EspañaSección Deptal. de Química Orgánica (Óptica y Optometría)Fac. de Óptica y OptometríaTRUEpu