19 research outputs found
Feasibility of Emergency Departmentâinitiated, Mobile Health Blood Pressure Intervention: An Exploratory, Randomized Clinical Trial
ObjectivesWe aimed to assess the feasibility of a text messaging intervention by determining the proportion of emergency department (ED) patients who responded to prompted home blood pressure (BP) selfâmonitoring and had persistent hypertension. We also explored the effect of the intervention on systolic blood pressure (sBP) over time.MethodsWe conducted a randomized, controlled trial of ED patients with expected discharge to home with elevated BP. Participants were identified by automated alerts from the electronic health record. Those who consented received a BP cuff to take home and enrolled in the 3âweek screening phase. Text responders with persistent hypertension were randomized to control or weekly prompted BP selfâmonitoring and healthy behavior text messages.ResultsAmong the 104 patients enrolled in the ED, 73 reported at least one home BP over the 3âweek runâin (screening) period. A total of 55 of 73 reported a home BP of â„140/90 and were randomized to SMS intervention (n = 28) or control (n = 27). The intervention group had significant sBP reduction over time with a mean drop of 9.1 mm Hg (95% confidence interval = 1.1 to 17.6).ConclusionsThe identification of ED patients with persistent hypertension using home BP selfâmonitoring and text messaging was feasible. The intervention was associated with a decrease in sBP likely to be clinically meaningful. Future studies are needed to further refine this approach and determine its efficacy.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/149295/1/acem13691.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/149295/2/acem13691_am.pd
Architecture Optimization Dramatically Improves Reverse Bias Stability in Perovskite Solar Cells: A Role of Polymer Hole Transport Layers
We report that device architecture engineering has a substantial impact on
the reverse bias instability that has been reported as a critical issue in
commercializing perovskite solar cells. We demonstrate breakdown voltages
exceeding -15 V in typical pin structured perovskite solar cells via two steps:
i) using polymer hole transporting materials; ii) using a more
electrochemically stable gold electrode. While device degradation can be
exacerbated by higher reverse bias and prolonged exposure, our as-fabricated
perovskite solar cells completely recover their performance even after
stressing at -7 V for 9 hours both in the dark and under partial illumination.
Following these observations, we systematically discuss and compare the reverse
bias driven degradation pathways in perovskite solar cells with different
device architectures. Our model highlights the role of electrochemical reaction
rates and species in dictating the reverse bias stability of perovskite solar
cells
Catching Element Formation In The Act
Gamma-ray astronomy explores the most energetic photons in nature to address
some of the most pressing puzzles in contemporary astrophysics. It encompasses
a wide range of objects and phenomena: stars, supernovae, novae, neutron stars,
stellar-mass black holes, nucleosynthesis, the interstellar medium, cosmic rays
and relativistic-particle acceleration, and the evolution of galaxies. MeV
gamma-rays provide a unique probe of nuclear processes in astronomy, directly
measuring radioactive decay, nuclear de-excitation, and positron annihilation.
The substantial information carried by gamma-ray photons allows us to see
deeper into these objects, the bulk of the power is often emitted at gamma-ray
energies, and radioactivity provides a natural physical clock that adds unique
information. New science will be driven by time-domain population studies at
gamma-ray energies. This science is enabled by next-generation gamma-ray
instruments with one to two orders of magnitude better sensitivity, larger sky
coverage, and faster cadence than all previous gamma-ray instruments. This
transformative capability permits: (a) the accurate identification of the
gamma-ray emitting objects and correlations with observations taken at other
wavelengths and with other messengers; (b) construction of new gamma-ray maps
of the Milky Way and other nearby galaxies where extended regions are
distinguished from point sources; and (c) considerable serendipitous science of
scarce events -- nearby neutron star mergers, for example. Advances in
technology push the performance of new gamma-ray instruments to address a wide
set of astrophysical questions.Comment: 14 pages including 3 figure
Modular Zwitterion-Functionalized Poly(Isopropyl Methacrylate) Polymers for Hosting Luminescent Lead-Halide Perovskite Nanocrystals
Inorganic lead-halide perovskite nanocrystals (NCs) are an exciting class
of luminescent materials with high defect tolerance and broad spectral
tunability, but such NCs are vulnerable to degradation under ambient conditions.
Here, we report a class of modular zwitterion-functionalized isopropyl methacrylate polymers designed to
stabilize a wide variety of perovskite NCs of different compositions, while also
enabling processing in green solvents. Specifically, we report polymers in
which the zwitterion spacing is tuned to accommodate the different lattice
parameters of CsPb(Cl1-xBrx)3 and
CsPbI3 NCs, and we report partially fluorinated polymers prepared to
accommodate the needs of infrared-emitting NCs. We show that as-synthesized
CsPbBr3, CsPbI3, and Yb3+:CsPbCl3
NCs are easily transferred into these zwitterionic polymers via a simple
ligand-exchange procedure. These NC/polymer composites were then cast into thin
films that showed substantially improved photoluminescence (PL) and stability compared
with more conventional NC/polymer films. Specifically, CsPbBr3 and
CsPbI3 NCs in films of their appropriately designed polymers had PL
quantum yields of ~90% and ~80%, respectively. PL quantum yields decreased
under continuous illumination, but self-healed completely after dark storage.
We also found that all the NC compositions studied here maintain their PL
quantum yields in NC/polymer composite films even after 1 year of ambient
storage. These encouraging results demonstrate the utility of such modular zwitterion-functionalized
polymers for hosting specific perovskite NCs, potentially opening avenues for
robust new photonic applications of this important class of NCs
Reach out emergency department: Partnering with an economically disadvantaged community in the development of a text-messaging intervention to address high blood pressure
© 2020 Society for Public Health Education. Background. Hypertension affects nearly 30% of the U.S. adult population. Due to the ubiquitous nature of mobile phone usage, text messaging offers a promising platform for interventions to assist in the management of chronic diseases including hypertension, including among populations that are historically underserved. We present the intervention development of Reach Out, a health behavior theoryâbased, mobile health intervention to reduce blood pressure among hypertensive patients evaluated in a safety net emergency department primarily caring for African Americans. Aims. To describe the process of designing and refining text messages currently being implemented in the Reach Out randomized controlled trial. Method. We used a five-step framework to develop the text messages used in Reach Out. These steps included literature review and community formative research, conception of a community-centered behavioral theoretical framework, draft of evidence-based text messages, community review, and revision based on community feedback and finalization. Results. The Reach Out development process drew from pertinent evidence that, combined with community feedback, guided the development of a community-centered health behavior theory framework that led to development of text messages. A total of 333 generic and segmented messages were created. Messages address dietary choices, physical activity, hypertension medication adherence, and blood pressure monitoring. Discussion. Our five-step framework is intended to inform future text-messaging-based health promotion efforts to address health issues in vulnerable populations. Conclusion. Text messageâbased health promotion programs should be developed in partnership with the local community to ensure acceptability and relevance
Prototype Development of a Temperature-Sensitive High-Adhesion Medical Tape to Reduce Medical-Adhesive-Related Skin Injury and Improve Quality of Care
Medical adhesives are used to secure wound care dressings and other critical devices to the skin. Without means of safe removal, these stronger adhesives are difficult to painlessly remove from the skin and may cause medical-adhesive-related skin injuries (MARSI), including skin tears and an increased risk of infection. Lower-adhesion medical tapes may be applied to avoid MARSI, leading to device dislodgement and further medical complications. This paper outlines the development of a high-adhesion medical tape designed for low skin trauma upon release. By warming the skin-attached tape for 10â30 s, a significant loss in adhesion was achieved. A C14/C18 copolymer was developed and combined with a selected pressure-sensitive adhesive (PSA) material. The addition of 1% C14/C18 copolymer yielded the largest temperature-responsive drop in surface adhesion. The adhesive film was characterized using AFM, and distinct nanodomains were identified on the exterior surface of the PSA. Our optimized formulation yielded 67% drop in adhesion when warmed to 45 °C, perhaps due to melting nanodomains weakening the adhesiveâsubstrate boundary layer. Pilot clinical testing resulted in a significant decrease in pain when a heat pack was used for removal, giving an average pain reduction of 66%
Reach out behavioral intervention for hypertension initiated in the emergency department connecting multiple health systems: study protocol for a randomized control trial
Abstract
Background
Hypertension is the most important modifiable risk factor for cardiovascular disease, the leading cause of mortality in the United States. The Emergency Department represents an underutilized opportunity to impact difficult-to-reach populations. There are 136 million visits to the Emergency Department each year and nearly all have at least one blood pressure measured and recorded. Additionally, an increasing number of African Americans and socioeconomically disadvantaged patients are overrepresented in the Emergency Department patient population. In the age of electronic health records and mobile health, the Emergency Department has the potential to become an integral partner in chronic disease management. The electronic health records in conjunction with mobile health behavior interventions can be leveraged to identify hypertensive patients to impact otherwise unreached populations.
Methods
Reach Out is a factorial trial studying multicomponent, behavioral interventions to reduce blood pressure in the Emergency Department patient population. Potential participants are identified by automated alerts from the electronic health record and, following consent, receive a blood pressure cuff to take home. During the initial screening phase, they are prompted to submit weekly blood pressure readings. Responders with persistent hypertension are then randomized into one of three component arms, consisting of varying intensity levels: (1) healthy behavior text messaging (daily vs. none), (2) blood pressure self-monitoring (daily vs. weekly), and (3) facilitated primary care provider appointment scheduling and transportation (yes vs. no). If participants are randomized to receive facilitated primary care provider appointment scheduling and are not established with a primary care provider, care will be established at a local Federally Qualified Health Center. Participants are followed for 12 months.
Discussion
The Reach Out study is designed to determine which behavioral intervention components or âdoseâ of components contributes to a reduction in systolic blood pressure after 1 year (Aim 1). The study will also assess the effect of primary care provider appointment assistance on total primary care follow-up visits of hypertensive patients treated in an urban, safety net Emergency Department (Aim 2). Ideally, the Reach Out system will contribute to hypertension management, serving as a model for safety net hospitals and Federally Qualified Health Centers to improve chronic disease management in underserved communities.
Trial registration
This study was registered at clinicaltrials.gov, identifier
NCT03422718
. The record was first available to the public on January 30, 2018 prior to the enrollment of patients on March 25, 2019.http://deepblue.lib.umich.edu/bitstream/2027.42/173818/1/13063_2020_Article_4340.pd