Towards a Historical Archaeology of the German-Canadiansof Markham\u27s Berczy Settlement

In his book In Small Things Forgotten, James Deetz (1977) challenged archaeologists to use material culture as a source of information about human actions that may not be represented widely in the written record. Consequently, studies of ethnic minority groups became popular in American historical archaeology from the 1970s onwards. Equally invisible, however, are immigrant groups who wish to blend in with-or whose character resembles that of-the charter group in a given region. This article presents a model that seeks to distinguish German and English ethnic identity through an analysis of ceramic vessels from five domestic sites occupied by some of the first immigrants to settle in Markham, Upper Canada (Ontario), ca. 1794 to the 1830s. In particular, differences and similarities observed in the ceramic vessel assemblages are interpreted within the contexts of the goods available in the embryonic settlement and the ethnic foodways of the sites\u27 occupants

The Survival of Planetary Nebulae in the Intracluster Medium

The stellar population stripped from galaxies in clusters evolve under the extreme conditions imposed by the intracluster (IC) medium. Intracluster stars generally suffer very high systemic velocities, and evolve within a rarefied and extremely hot IC medium. We present numerical simulations which aim to explore the evolution and survival of IC Asymptotic Giant Branch (AGB) envelopes and Planetary Nebula (PN) shells. Our models reflect the evolution of a low-mass star under the observed conditions in the Virgo IC medium. We find that the integrated hydrogen-recombination line emission of a PN is dominated by the inner dense shell, whose evolution is unaffected by the environment. Ram pressure stripping affects mainly the outermost IC PN shell, which hardly influences the emission when the PN is observed as a point source. More importantly, we find that a PN with progenitor mass of 1 Msun fades to ~30% and 10% of its maximum emission, in 5,000 and 10,000 yr respectively, disclosing an actual PN lifetime t_PN several times shorter to what is usually adopted (25,000 yr). This result affects the theoretical calculation of the luminosity-specific density of IC PNe, which scales with t_PN. For t_PN=10,000 yr, our more conservative estimate, we obtain that the luminosity-specific density of PNe is in fair agreement with the value obtained from Red Giants. With our more realistic PN lifetime we infer a higher fraction (above 15%) of IC starlight in the Virgo core than current estimates.Comment: Accepted for publication in the Astrophysical Journal 14 pages, including 2 figure

Occupied by the Enemy: The Skirmishes at the Butler Farm during the War of 1812

The American army landed near the mouth of Two Mile Creek on 27 May 1813 to continue its campaign on British territory, with an eye to capturing Fort George in present-day Niagara-on-the-Lake. The Americans established one of their piquets at the residence of Johnson Butler, whose father, Colonel John Butler, oversaw the Loyalist settlement of Niagara in the 1780s. The Butler farm became the location of three skirmishes between the Americans and British that took place during the summer and fall of 1813, and, ultimately, the Butler house was destroyed when the Americans surrendered Fort George and retreated from Niagara in December of 1813. The partial excavation of the Butler Homestead site in 1999, which included the hand excavation of 361 m2 of topsoil, affords the opportunity to discern what constitutes the archaeological evidence of the War of 1812, given the array of lead balls, lead shot, gunflints, gun parts, and uniform accoutrements in the assemblage. In this article, particular attention will be given to the material culture of war and its distribution across the site

Dining with John and Catharine Butler before the Close of the Eighteenth Century

The partial excavation of the homestead of Colonel John Butler in the town of Niagara-on-the-Lake has afforded the opportunity to explore the daily activities of one Loyalist family after the establishment of the British colony of Upper Canada in the 1780s. In particular, the large collection of zooarchaeological material (over 14,5000 specimens) can provide information about the availability of wild animal species, as well as the types of domestic animals that the Butlers kept on their farm. Butchering marks provide further insight into the types of meat cuts used in cooking meals for the family and guests. These are compared and contrasted with the ceramic and glass vessels, so that these analyses can be brought together to paint a picture of what it might have been like to dine with John and Catharine Butler before the close of the 18th century

Glia Cell Morphology Analysis Using the Fiji GliaMorph Toolkit

Glial cells are the support cells of the nervous system. Glial cells typically have elaborate morphologies that facilitate close contacts with neighboring neurons, synapses, and the vasculature. In the retina, Müller glia (MG) are the principal glial cell type that supports neuronal function by providing a myriad of supportive functions via intricate cell morphologies and precise contacts. Thus, complex glial morphology is critical for glial function, but remains challenging to resolve at a sub-cellular level or reproducibly quantify in complex tissues. To address this issue, we developed GliaMorph as a Fiji-based macro toolkit that allows 3D glial cell morphology analysis in the developing and mature retina. As GliaMorph is implemented in a modular fashion, here we present guides to (a) setup of GliaMorph, (b) data understanding in 3D, including z-axis intensity decay and signal-to-noise ratio, (c) pre-processing data to enhance image quality, (d) performing and examining image segmentation, and (e) 3D quantification of MG features, including apicobasal texture analysis. To allow easier application, GliaMorph tools are supported with graphical user interfaces where appropriate, and example data are publicly available to facilitate adoption. Further, GliaMorph can be modified to meet users’ morphological analysis needs for other glial or neuronal shapes. Finally, this article provides users with an in-depth understanding of data requirements and the workflow of GliaMorph. © 2023 The Authors. Current Protocols published by Wiley Periodicals LLC. Basic Protocol 1: Download and installation of GliaMorph components including example data Basic Protocol 2: Understanding data properties and quality 3D—essential for subsequent analysis and capturing data property issues early Basic Protocol 3: Pre-processing AiryScan microscopy data for analysis Alternate Protocol: Pre-processing confocal microscopy data for analysis Basic Protocol 4: Segmentation of glial cells Basic Protocol 5: 3D quantification of glial cell morpholog

Considerations of complexity in rating certainty of evidence in systematic reviews:a primer on using the GRADE approach in global health

Public health interventions and health technologies are commonly described as 'complex', as they involve multiple interacting components and outcomes, and their effects are largely influenced by contextual interactions and system-level processes. Systematic reviewers and guideline developers evaluating the effects of these complex interventions and technologies report difficulties in using existing methods and frameworks, such as the Grading of Recommendations Assessment, Development and Evaluation (GRADE). As part of a special series of papers on implications of complexity in the WHO guideline development, this paper serves as a primer on how to consider sources of complexity when using the GRADE approach to rate certainty of evidence. Relevant sources of complexity in systematic reviews, health technology assessments and guidelines of public health are outlined and mapped onto the reported difficulties in rating the estimates of the effect of these interventions. Recommendations on how to address these difficulties are further outlined, and the need for an integrated use of GRADE from the beginning of the review or guideline development is emphasised. The content of this paper is informed by the existing GRADE guidance, an ongoing research project on considering sources of complexity when applying the GRADE approach to rate certainty of evidence in systematic reviews and the review authors' own experiences with using GRADE

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Controlling food, controlling relationships: exploring the meanings and dynamics of family food practices through the diary-interview approach

Potential merits of a social practice perspective for examining the meanings and dynamics of family food include moving beyond individual behaviour, and exploring how practices emerge, develop and change. However, researchers have struggled to encourage reflection on mundane practices, and how to understand associated meanings. Drawing on a study of families in South Wales, this article reflects on the value of the diary‐interview approach in addressing these methodological challenges, and aims to explore and understand the dynamics of control across family contexts. Contemporary practice theories distinguish between practices as ‘performances’ and practices as ‘entities’ and the diary‐interview method facilitated an examination of these dimensions. Detailed accounts of daily ‘performances’ (through diaries), alongside reflection on underlying contexts and ‘entities’ (through interviews), illustrated the entanglement of control, practices and context. The article adds further complexity to the concept of practice ‘bundles’ which facilitated an understanding of how food was interrelated with other practices – across family contexts and across generations. Sociological approaches with a practices perspective at the core, offer potential for developing public health interventions by acknowledging: the relational meaning of food; the embeddedness of food within everyday practices; and the need to consider interventions across a range of policy areas

Long-Term Ranibizumab Treatment in Neovascular Age-Related Macular Degeneration: A Belgian Subanalysis from the Global Real-World LUMINOUS TM Study

To evaluate long-term, real-world treatment patterns and outcomes of ranibizumab 0.5 mg for neovascular age-related macular degeneration (nAMD) in a Belgian cohort.; This Belgian (BE) cohort of the 5-year global observational LUMINOUS study included 229 patients with nAMD. Outcomes included visual acuity (VA), central retinal thickness (CRT) and safety.; The mean age was 79.5±7.7 years. The majority of patients (67.7%) were female and all patients were Caucasian. Most patients previously received ranibizumab with only 17.5% of patients being treatment-naïve. The injection frequency declined over time irrespective of prior treatment status (p<0.0001), with treatment-naïve eyes receiving a mean of 4.2±2.9 yearly injections and prior-ranibizumab eyes 3.6±2.7. Regression analysis confirmed first-year VA increases for treatment-naïve eyes (p=0.002) followed by a slight decrease of -1.8 letters per year. For prior-ranibizumab eyes, the visual changes over 1 year were statistically non-significant (p=0.90) but declined slightly after year one (p<0.0001). Anatomically, the CRT of treatment-naïve eyes decreased over time from baseline (p<0.0001), whereas the CRT of prior-ranibizumab eyes remained stable (p=0.43). No new safety findings were identified.; LUMINOUS-BE reconfirms the well-characterized benefit-risk profile of ranibizumab for nAMD treatment. The observed low injection frequency reflects a need for more rigorous treatment in real-world settings.; NCT01318941

App-based food-specific inhibitory control training as an adjunct to treatment as usual in binge-type eating disorders: a feasibility trial

Current treatments for binge eating disorder (BED) and bulimia nervosa (BN) only show moderate efficacy, warranting the need for novel interventions. Impairments in food-related inhibitory control contribute to BED/BN and could be targeted by food-specific inhibitory control training (ICT). The aim of this study was to establish the feasibility and acceptability of augmenting treatment for individuals with BN/BED with an ICT app (FoodT), which targets motor inhibition to food stimuli using a go/no-go paradigm. Eighty patients with BED/BN receiving psychological and/or pharmacological treatment were randomly allocated to a treatment-as-usual group (TAU; n = 40) or TAU augmented with the 5-min FoodT app daily (n = 40) for 4 weeks. This mixed-methods study assessed feasibility outcomes, effect sizes of clinical change, and acceptability using self-report measures. Pre-registered cut-offs for recruitment, retention, and adherence were met, with 100% of the targeted sample size (n = 80) recruited within 12 months, 85% of participants retained at 4 weeks, and 80% of the FoodT + TAU group completing ≤8 sessions. The reduction in binge eating did not differ between groups. However, moderate reductions in secondary outcomes (eating disorder psychopathology: SES = −0.57, 95% CI [-1.12, −0.03]; valuation of high energy-dense foods: SES = −0.61, 95% CI [-0.87, −0.05]) were found in the FoodT group compared to TAU. Furthermore, small greater reductions in food addiction (SES = −0.46, 95% CI [-1.14, 0.22]) and lack of premeditation (SES = −0.42, 95% CI [-0.77, −0.07]) were found in the FoodT group when compared to TAU. The focus groups revealed acceptability of FoodT. Participants discussed personal barriers (e.g. distractions) and suggested changes to the app (e.g. adding a meditation exercise). Augmenting treatment for BED/BN with a food-specific ICT app is feasible, acceptable, and may reduce clinical symptomatology with high reach and wide dissemination