293 research outputs found
Engineering - young people want to be informed
Young people in developed nations recognise the contribution that science and technology make to society and acknowledge their importance now and in the future, yet few view their study as leading to interesting careers. Some countries are taking action to raise interest in science, technologies, engineering and mathematics and increase the number of students studying these subjects. One of the barriers to young people pursuing engineering is their limited or distorted perception of it - they associate it only with building and fixing things. Young people rarely encounter engineers, unlike other professionals, engineering has little or no advocacy in the media and there are few opportunities to experience engineering. Many of the pupils surveyed at the start of Engineering the Future, a three year EPSRC-funded project, wrote âdonât know what engineering isâ and/or âwould like more informationâ. This paper reports on work with researchers, policy makers and practitioners in Scotland to develop a sustainable model of activities and interactions that develops pupilsâ understanding of the nature of engineering, embeds experiences of engineering within the school classroom and curriculum and promotes engineering as a career. After learning about engineering through the activities the pupilsâ perceptions had improved. Almost all considered it important that young people know about engineering, because it is an essential part of everyday life and, in the words of one pupil - âIf we know more about it, our minds wouldnât stay closed to it. We would maybe take it up.
Insights into frequent asthma exacerbations from a primary care perspective and the implications of UK National Review of Asthma Deaths recommendations
The United Kingdom National Review of Asthma Deaths (NRAD) recommends that patients who require â„3 courses of oral corticosteroids (OCS) for exacerbations in the past year or those on British Thoracic Society (BTS) Step 4/5 treatment must be referred to a specialist asthma service. The aim of the study was to identify the proportion of asthma patients in primary care that fulfil NRAD criteria for specialist referral and factors associated with frequent exacerbations. A total of 2639 adult asthma patients from 10 primary care practices in Glasgow, UK were retrospectively studied between 2014 and 2015. Frequent exacerbators and short-acting ÎČ2-agonist (SABA) over-users were identified if they received â„2 confirmed OCS courses for asthma and â„13 SABA inhalers in the past year, respectively. Community dispensing data were used to assess treatment adherence defined as taking â„75% of prescribed inhaled corticosteroid (ICS) dose. The study population included 185 (7%) frequent exacerbators, 137 (5%) SABA over-users, and 319 (12%) patients on BTS Step 4/5 treatment. Among frequent exacerbators, 41% required BTS Step 4/5 treatment, 46% had suboptimal ICS adherence, 42% had not attended an asthma review in the past year and 42% had no previous input from a specialist asthma service. Older age, female gender, BTS Step 4/5, SABA over-use and co-existing COPD diagnosis increased the risk of frequent exacerbations independently. Fourteen per 100 asthma patients would fulfil the NRAD criteria for specialist referral. Better collaboration between primary and secondary care asthma services is needed to improve chronic asthma care
Stranded and equilibrated assemblages of late feldspars in two granitic pegmatites in the Pampean Ranges, Argentina
Late primary K-feldspar in two granitic pegmatites from the Pampean pegmatite province in Argentina shows similar patterns of growth and exsolution, but different structural states and mineral associations. (i) In El Criollo, a beryl - columbite - phosphate pegmatite in the Punilla pegmatite field, a single miarolitic cavity in the blocky zone is lined with pale rusty crystals of veinperthitic K-feldspar and quartz. The Kfs host, Or89.7 Ab7.8 Rbf0.3 LEf(? 1.1 (âĄSi4O8)1.2 (âŒ88 vol.%), corresponds to optically and XRD-monoclinic, but highly (Al,Si -ordered orthoclase (2t1 = 0.82), with only a slight incipient conversion to intermediate grid-twinned microcline along contacts with exsolved low albite, Ab98.1 An1.2 Or0.9 (âŒ12 vol.%). The homogeneous precursor of the perthite contained âŒ22 mole % Abss. The perthitic orthoclase is overgrown, mainly on the {010} faces, by nonperthitic, gemmy, pale grey to beige orthoclase, Or91.6 Ab6.1 Rbf0.5 Cno.2 Srf0.1 LEf(?)0.2 (âĄSi4O8)1.5, with 2t1 equal to 0.84. Small tabular crystals of white low albite, Ab99.5 Or0.7, elongate parallel to c, are situated on the {010} faces of the orthoclase in epitactic orientation. (ii) In San Luis II, a spodumene pegmatite in El Totoral pegmatite field, crystals of coarsely perthitic K-feldspar and quartz line cavities in the core-margin zone. The mottled-grey euhedral K-feldspar, Or92.3 Ab4.1 Rbf1.1 Csf0.1 Cn0.1 Srf0.1 LEf(?)1.5 (âĄSi4O8)0.8 (âŒ92 vol.%), locally altered to muscovite and clay minerals, is very close to end-member low microcline with vein-shaped exsolution lamellae of low albite. Ab99.1 An0.1 Or0.4 Cn0.1 Srf0.1 (âŒ8 vol.%). The homogeneous precursor of the perthite contained âŒ13 mole % Abss. All faces of the perthite crystals have an even overgrowth of pale grey, nonperthitic low microcline, Or92.8 Ab4.8 Rbf0.2 Srf0.1 LEf(? 1.8(âĄSi4O8)0.3. The cavity space among the crystals of the K-feldspar and primary quartz is largely filled by microcrystalline secondary quartz, "chalcedony", opal and goethite. Different subsolidus histories of the two host vugs explain the conspicuous contrast between the structural states of their cavity-lining K-feldspar. In El Criollo pegmatite, the cavity probably quickly lost residual aqueous fluid, as the orthoclase of both the primary perthitic crystals and particularly of the gemmy overgrowth show only stranded, coherent domain-scale order and twinning, and very limited alteration. In the San Luis II pegmatite, the cavity-lining K-feldspar shows considerable alteration and overgrowth by low-temperature phases, indicative of substantial hydrothermal activity, which promoted (Al,Si)-ordering to give tartan-twinned low microcline in both the primary perthitic crystals and the norperthitic overgrowths.Le feldspath potassique primaire qui sâest formĂ© tardivement dans deux pegmatites granitiques de la province pegmatitique de Pampea, en Argentine, montre des points communs en termes de croissance et dâexsolution, mais des diffĂ©rences marquĂ©es en termes du degrĂ© dâordre et dâassociations minĂ©rales. (i) A El Criollo, une pegmatite Ă bĂ©ryl â columbite â phosphate du champ pegmatitique de Punilla, une seule cavitĂ© miarolitique de la zone Ă cristaux polyĂ©driques est tapissĂ©e de cristaux pĂąles de couleur rouille de feldspath potassique, perthitique Ă veines, avec quartz. LâhĂŽte dans cette perthite, Or89.7 Ab7.8 Rbf0.3 LEf(?)1.1 (Si4O8)1.2 (~88% en volume), correspond optiquement et en diffraction X Ă une phase monoclinique (orthose) fortement ordonnĂ©e, avec 2t1 = 0.82, et un dĂ©but de conversion Ă la microcline intermĂ©diaire avec maclage quadrillĂ© le long des contacts avec lâalbite ordonnĂ©e exsolvĂ©e, Ab98.1 An1.2 Or0.9 (~12% en volume). Le prĂ©curseur homogĂšne de la perthite contenait ~22% Abss (base molaire). Lâorthose perthitique est recouverte, surtout sur les faces {010}, dâune surcroissance dâorthose non perthitique, gemme, gris pĂąle Ă beige, Or91.6 Ab6.1 Rbf0.5 Cn0.2 Srf0.1 LEf(?)0.2 (Si4O8)1.5, avec 2t1 egal Ă 0.84. De petits cristaux tabulaires blancs dâalbite ordonnĂ©e, Ab99.5 Or0.7, allongĂ©s parallĂšles Ă c, recouvrent les faces {110} de lâorthose, en relation Ă©pitactique. (ii) A San Luis II, une pegmatite Ă spodumĂšne du champ de El Totoral, des cristaux grossiers et perthitiques de feldspath potassique et de quartz tapissent les cavitĂ©s de la zone externe du coeur du massif. Les cristaux idiomorphes de feldspath potassique sont gris nuagĂ©, Or92.3 Ab4.1 Rbf1.1 Csf0.1 Cn0.1 Srf0.1 LEf(?)1.5 (Si4O8)0.8 (~92% en volume), localement transformĂ©s en muscovite et en argiles; ils sont trĂšs prĂšs du pĂŽle microcline ordonnĂ©, avec des lamelles exsolvĂ©es en veines dâalbite ordonnĂ©e, Ab99.1 An0.1 Or0.4 Cn0.1 Srf0.1 (~8% en volume). Le prĂ©curseur homogĂšne de la perthite contenait ~13% dâalbite Abss (base molaire). Toutes les faces des cristaux de perthite sont recouvertes dâune surcroissance uniforme gris pĂąle de microline ordonnĂ© non perthitique, Or92.8 Ab4.8 Rbf0.2 Srf0.1 LEf(?)1.8(Si4O8)0.3. Les espaces entre les cristaux de feldspath potassique et de quartz sont surtout remplis de quartz microcristallin secondaire, âcalcĂ©doineâ, opale et goethite. Des diffĂ©rences dans lâĂ©volution subsolidus des deux cavitĂ©s hĂŽtes expliquent le contraste frappant en termes du degrĂ© dâordre du feldspath potassique sur les parois. Dans la pegmatite de El Criollo, la cavitĂ© a probablement perdu la phase fluide rĂ©siduelle rapidement; lâorthose des cristaux primaires devenus perthitiques et de la surcroissance gemme ne contient que des domaines ordonnĂ©s cohĂ©rents et maclĂ©s, conservĂ©s de façon mĂ©tastable, et trĂšs peu dâaltĂ©ration. Dans la pegmatite de San Luis II, les cristaux de feldspath potassique le long des parois montrent des signes importants dâaltĂ©ration et de surcroissances de phases de basse tempĂ©rature, indications dâune activitĂ© hydrothermale substantielle, qui a favorisĂ© la mise en ordre (Al,Si) du feldpath pour mener Ă la forme Ă maclage quadrillĂ© du microcline ordonnĂ©, aussi bien dans les cristaux perthitiques que dans les surcroissances non perthitiques.Fil: Cerny, Petr. University of Manitoba; CanadĂĄFil: Galliski, Miguel Angel. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - Mendoza. Instituto Argentino de NivologĂa, GlaciologĂa y Ciencias Ambientales. Provincia de Mendoza. Instituto Argentino de NivologĂa, GlaciologĂa y Ciencias Ambientales. Universidad Nacional de Cuyo. Instituto Argentino de NivologĂa, GlaciologĂa y Ciencias Ambientales; Argentina. Ministerio de Relaciones Exteriores, Comercio Internacional y Culto. Direccion Nacional del AntĂĄrtico. Instituto AntĂĄrtico Argentino. Instituto AntĂĄrtico Argentino - Sede Cricyt (Mendoza); ArgentinaFil: Oyarzabal, Julio C.. Universidad Nacional de San Luis; ArgentinaFil: Teertstra, David K.. University of Manitoba; CanadĂĄFil: Chapman, Ron. University of Manitoba; CanadĂĄFil: MacBride, Lyndsey. University of Manitoba; CanadĂĄFil: Ferreira, Karen. University of Manitoba; Canad
Towards an Ontological Modelling of Preference Relations
Preference relations are intensively studied in Economics,
but they are also approached in AI, Knowledge Representation, and
Conceptual Modelling, as they provide a key concept in a variety of
domains of application. In this paper, we propose an ontological foundation
of preference relations to formalise their essential aspects across
domains. Firstly, we shall discuss what is the ontological status of the
relata of a preference relation. Secondly, we investigate the place of preference
relations within a rich taxonomy of relations (e.g. we ask whether
they are internal or external, essential or contingent, descriptive or nondescriptive
relations). Finally, we provide an ontological modelling of
preference relation as a module of a foundational (or upper) ontology
(viz. OntoUML).
The aim of this paper is to provide a sharable foundational theory of
preference relation that foster interoperability across the heterogeneous
domains of application of preference relations
Electron and proton heating by solar wind turbulence
Previous formulations of heating and transport associated with strong
magnetohydrodynamic (MHD) turbulence are generalized to incorporate separate
internal energy equations for electrons and protons. Electron heat conduction
is included. Energy is supplied by turbulent heating that affects both
electrons and protons, and is exchanged between them via collisions. Comparison
to available Ulysses data shows that a reasonable accounting for the data is
provided when (i) the energy exchange timescale is very long and (ii) the
deposition of heat due to turbulence is divided, with 60% going to proton
heating and 40% into electron heating. Heat conduction, determined here by an
empirical fit, plays a major role in describing the electron data
Spectropolarimetric Fluctuations in a Sunspot Chromosphere
The instrumental advances made in this new era of 4-meter class solar
telescopes with unmatched spectropolarimetric accuracy and sensitivity, will
enable the study of chromospheric magnetic fields and their dynamics with
unprecedented detail. In this regard, spectropolarimetric diagnostics can
provide invaluable insight into magneto-hydrodynamic (MHD) wave processes. MHD
waves and, in particular, Alfv\'enic fluctuations associated to particular wave
modes, were recently recognized as important mechanisms not only for the
heating of the outer layers of the Sun's atmosphere and the acceleration of the
solar wind, but also for the elemental abundance anomaly observed in the corona
of the Sun and other Sun-like stars (also known as first ionisation potential;
FIP) effect. Here, we take advantage of state-of-the-art and unique
spectropolarimetric IBIS observations to investigate the relation between
intensity and circular polarisation (CP) fluctuations in a sunspot
chromosphere. Our results show a clear link between the intensity and CP
fluctuations in a patch which corresponds to a narrow range of magnetic field
inclinations. This suggests the presence of Alfv\'enic perturbations in the
sunspot.Comment: 15 pages, 5 figures. Accepted for publication in Philosophical
Transactions of the Royal Society
Solar Wind Turbulence and the Role of Ion Instabilities
International audienc
Key Considerations From a Health Authority Perspective When Proton Pump Inhibitors Are Used to Treat Gastroesophageal Reflux Disease (GERD) and Their Implications
The growing prevalence of gastroesophageal reflux disease (GERD) needs to be carefully managed to relieve the symptoms and prevent complications. Complications of GERD can include erosive esophagitis, Barrettâs esophagus and gastrointestinal (GI) bleeding. Proton pump inhibitors (PPIs) are typically first-line treatment for GERD alongside lifestyle changes in view of their effectiveness and cost-effectiveness. However, there are concerns with adherence to dosing regimens and recommended lifestyle changes reducing their effectiveness. There are also concerns about potential complications from chronic high-dose PPIs. These include an increased risk of chronic kidney disease, cardiovascular events and infections. Recommendations to physicians include prescribing or dispensing the lowest dose of PPI for the shortest time, with ongoing patient monitoring. Activities among community pharmacists and others have resulted in increased dispensing of PPIs without a prescription, which can be a challenge. PPIs are among the most prescribed and dispensed medicines in view of their effectiveness in managing GERD. However, there are concerns with the doses prescribed and dispensed as well as adherence to lifestyle advice. These issues and challenges need to be addressed by health authorities to maximize the role and value of PPIs
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