Application of Lie Symmetry to a Mathematical Model that Describes a Cancer Sub-Network

In this paper, a mathematical model of a cancer sub-network is analysed from the view point of Lie symmetry methods. This model discusses a human cancer cell which is developed due to the dysfunction of some genes at the R-checkpoint during the cell cycle. The primary purpose of this paper is to apply the techniques of Lie symmetry to the model and present some approximated solutions for the three-dimensional system of first-order ordinary differential equations describing a cancer sub-network. The result shows that the phosphatase gene (Cdc25A) regulates the cyclin-dependent kinases inhibitor (P27Kip1). Furthermore, this research discovered that the activity that reverses the inhibitory effects on cell cycle progression at the R-checkpoint initiates a pathway

Lie Symmetry Analysis of a Nonlinear System Characterizing Endemic Malaria

In this paper, the integrability of a nonlinear system developing endemic Malaria was demonstrated using Prelle–Singer techniques. In addition, Lie symmetry techniques were employed to identify additional independent variables that led to the modification of the nonlinear model and the development of analytical solutions

Optimal Control Analysis of a Mathematical Model for Breast Cancer

In this paper, a mathematical model of breast cancer governed by a system of ordinary differential equations in the presence of chemotherapy treatment and ketogenic diet is discussed. Several comprehensive mathematical analyses were carried out using a variety of analytical methods to study the stability of the breast cancer model. Also, sufficient conditions on parameter values to ensure cancer persistence in the absence of anti-cancer drugs, ketogenic diet, and cancer emission when anti-cancer drugs, immune-booster, and ketogenic diet are included were established. Furthermore, optimal control theory is applied to discover the optimal drug adjustment as an input control of the system therapies in order to minimize the number of cancerous cells by considering different controlled combinations of administering the chemotherapy agent and ketogenic diet using the popular Pontryagin’s maximum principle. Numerical simulations are presented to validate our theoretical results

Qualitative Analysis of a Dengue Fever Model

In this paper, a deterministic mathematical model of the Dengue virus with a nonlinear incidence function in a population is presented and rigorously analysed. The model incorporates control measures at the aquatic and adult stages of the vector (mosquito). The stability of the system is analysed for the disease-free equilibrium and the existence of endemic equilibria under certain conditions. The local stability of the Dengue-free equilibrium is investigated via the threshold parameter (reproduction number) that was obtained using the next-generation matrix techniques. The Routh–Hurwitz criterion, along with Descartes’ rule of signs change, established the local asymptotically stability of the model whenever R0<1 and was unstable otherwise. The comparison theorem was used to establish the global asymptomatically stability of the model