Long-Term Kidney and Maternal Outcomes After Pregnancy in Living Kidney Donors

For counseling it is important to know if pregnancy after Living Kidney Donation (LKD) affects long-term outcomes of the mono-kidney and the mother. Therefore, we performed a retrospective multicenter study in women ≤45 years who donated their kidney between 1981 and 2017. Data was collected via questionnaires and medical records. eGFR of women with post-LKD pregnancies were compared to women with pre-LKD pregnancies or nulliparous. eGFR before and after pregnancy were compared in women with post-LKD pregnancies. Pregnancy outcomes post-LKD were compared with pre-LKD pregnancy outcomes. 234 women (499 pregnancies) were included, of which 20 with pre- and post-LKD pregnancies (68) and 26 with only post-LKD pregnancies (59). Multilevel analysis demonstrated that eGFR was not different between women with and without post-LKD pregnancies (p = 0.23). Furthermore, eGFR was not different before and after post-LKD pregnancy (p = 0.13). More hypertensive disorders of pregnancy (HDP) occurred in post-LKD pregnancies (p = 0.002). Adverse fetal outcomes did not differ. We conclude that, despite a higher incidence of HDP, eGFR was not affected by post-LKD pregnancy. In line with previous studies, we found an increased risk for HDP after LKD without affecting fetal outcome. Therefore, a pregnancy wish alone should not be a reason to exclude women for LKD.</p

Data underlying the publication: Optimizing micropollutant removal by ozonation; interference of effluent organic matter fractions

Data underlying the publication: Optimizing micropollutant removal by ozonation; interference of effluent organic matter fractions. In this dataset, the raw data on which the figures in the abovementioned publications are based can be found

Optimizing Micropollutant Removal by Ozonation; Interference of Effluent Organic Matter Fractions

Ozonation for micropollutant removal from wastewater treatment plant effluent is energy and cost-intensive because of competition between background organic matter and micropollutants. This study aims to elucidate the interference of different organic matter fractions during the ozonation of micropollutants. Wastewater treatment plant effluent was fractionated using membranes and XAD-8 resin. All membrane and resin fractions were spiked with 18 micropollutants (2 µg/L) and ozonated with 0.25, 0.5 and 1 g O3/g TOC. Results show that these fractions differ in their interference with the ozonation of micropollutants. Interference was lower in the smallest size fraction (<1 kDa) than in all other fractions for micropollutants with low and medium ozone reactivity. The hydrophobic neutrals and hydrophilics resin factions showed a high interference for ozonation of micropollutants with medium and high ozone reactivity, respectively. The four parameters that were analyzed (specific UV absorbance at 254 nm, fluorescence, chemical oxygen demand and nitrite) could not elucidate the differences in micropollutant removal. Still, we conclude that understanding the type of organic matter present in the matrix, is essential to optimize micropollutant ozonation and other tertiary micropollutant removal treatments