The antioxidative-prooxidative balance in children with asthma treated with inhaled corticosteroids and long acting β2-agonists

The aim of study was to analyze the effect of treatment with inhaled corticosteroids and long acting ß2-agonists on antioxidative-prooxidative balance in children with asthma. Material and methods: Twenty children with newly diagnosed asthma before treatment (group I), fourteen children with diagnosed asthma treated with inhaled corticosteroids and long acting β2-agonists and 57 healthy children were ioncluded in the study. In all cases plasma protein carbonyls and activity of erythrocyte SOD was assayed. Results: Plasma protein carbonyls in both group I (1,01 nmol/g of protein, SD=0,30) and group II (0,94; SD=0,15) was significantly higher than in group III (0,85; SD=0,24) (I vs. III