Leadership within Collegiate Student Organizations: Does Membership Contribute to Leadership Development?

Student organizations vary in membership size, values, mission, and organizational structure, which can create a variety of leadership opportunities for students. However, there is an unclear understanding regarding the association between student organizational leadership, career preparation, and leadership development

A Chemical and Enzymatic Approach to Study Site-Specific Sumoylation.

A variety of cellular pathways are regulated by protein modifications with ubiquitin-family proteins. SUMO, the Small Ubiquitin-like MOdifier, is covalently attached to lysine on target proteins via a cascade reaction catalyzed by E1, E2, and E3 enzymes. A major barrier to understanding the diverse regulatory roles of SUMO has been a lack of suitable methods to identify protein sumoylation sites. Here we developed a mass-spectrometry (MS) based approach combining chemical and enzymatic modifications to identify sumoylation sites. We applied this method to analyze the auto-sumoylation of the E1 enzyme in vitro and compared it to the GG-remnant method using Smt3-I96R as a substrate. We further examined the effect of smt3-I96R mutation in vivo and performed a proteome-wide analysis of protein sumoylation sites in Saccharomyces cerevisiae. To validate these findings, we confirmed several sumoylation sites of Aos1 and Uba2 in vivo. Together, these results demonstrate that our chemical and enzymatic method for identifying protein sumoylation sites provides a useful tool and that a combination of methods allows a detailed analysis of protein sumoylation sites

Intersession Reliability and Within-Session Stability of a Novel Perception-Action Coupling Task

BACKGROUND: The perception-action coupling task (PACT) was designed as a more ecologically valid measure of alertness/reaction times compared to currently used measures by aerospace researchers. The purpose of this study was to assess the reliability, within-subject variability, and systematic bias associated with the PACT. METHODS: There were 16 subjects (men/women = 9/7; age = 27.8 +/- 3.6 yr) who completed 4 identical testing sessions. The PACT requires subjects to make judgements on whether a virtual ball could fit into an aperture. For each session, subjects completed nine cycles of the PACT, with each cycle lasting 5 min. Judgement accuracy and reaction time parameters were calculated for each cycle. Systematic bias was assessed with repeated-measures ANOVA, reliability with intraclass correlation coefficients (ICC), and within-subject variability with coefficients of variation (CVTE). RESULTS: Initiation time (Mean = 0.1065 s) showed the largest systematic bias, requiring the elimination of three cycles to reduce bias, with all other variables requiring, at the most, one. All variables showed acceptable reliability (ICC > 0.70) and within-subject variability (CVTE <20%) with only one cycle after elimination of the first three cycles. CONCLUSIONS: With a three-cycle familiarization period, the PACT was found to be reliable and stable

Adopting the Principles of Universal Design into International and Global Studies’ Programs and Curriculum

The ideals of universal design have profoundly impacted instruction, policy, and infrastructure in course architecture and design within elementary education and at some universities. Within international and global studies, however, these principles have not deeply affected either pedagogy or scholarship despite the fact that classes in international studies may include more international students and third culture kids1 than classes in other programs. Instead, in North America (as well as in much of Latin America and Europe), the current pedagogical model calls for students either to develop strategies on their own to succeed in class or to self-identify with documented disabilities if they need particular assistance or accommodation. This approach relies on a banking model for education, which does not focus upon learner agency. This paper argues that by adopting three principles—learner autonomy, the negotiated syllabus, and universal design—international and global studies programs can better meet the needs of diverse learners and reflect the field’s commitment to inclusion and social justice

Remote Sensing for Precision Agriculture: Sentinel-2 Improved Features and Applications

The use of satellites to monitor crops and support their management is gathering increasing attention. The improved temporal, spatial, and spectral resolution of the European Space Agency (ESA) launched Sentinel-2 A + B twin platform is paving the way to their popularization in precision agriculture. Besides the Sentinel-2 A + B constellation technical features the open-access nature of the information they generate, and the available support software are a significant improvement for agricultural monitoring. This paper was motivated by the challenges faced by researchers and agrarian institutions entering this field; it aims to frame remote sensing principles and Sentinel-2 applications in agriculture. Thus, we reviewed the features and uses of Sentinel-2 in precision agriculture, including abiotic and biotic stress detection, and agricultural management. We also compared the panoply of satellites currently in use for land remote sensing that are relevant for agriculture to the Sentinel-2 A + B constellation features. Contrasted with previous satellite image systems, the Sentinel-2 A + B twin platform has dramatically increased the capabilities for agricultural monitoring and crop management worldwide. Regarding crop stress monitoring, Sentinel-2 capacities for abiotic and biotic stresses detection represent a great step forward in many ways though not without its limitations; therefore, combinations of field data and different remote sensing techniques may still be needed. We conclude that Sentinel-2 has a wide range of useful applications in agriculture, yet still with room for further improvements. Current and future ways that Sentinel-2 can be utilized are also discussed.This research was funded by the Spanish projects AGL2016-76527-R and IRUEC PCIN-2017-063 from the Ministerio de Economía y Competividad (MINECO, Spain) and by the support of Catalan Institution for Research and Advanced Studies (ICREA, Generalitat de Catalunya, Spain), through the ICREA Academia Program

“This is who we are!” National identity construction and the 2014 FIFA World Cup

Drawing on the literature on American nationalism and the social identity perspective, this study examines the effects of mediasport on nationalized attitudes, using both rhetorical and experimental approaches. First, a rhetorical analysis examined the nationalistic themes featured in the game promotional ad of the United States versus Ghana soccer match in World Cup 2014, linking these themes to the republicanism/liberalism paradox in American political thought. Using the social identity perspective, we predicted the effects of these themes on U.S. participants’ nationalized attitudes and tested our hypotheses using an experiment. Experimental findings indicate that exposure to nationalistic rhetoric indirectly increases uncritical patriotism, critical patriotism, and support of militarism attitudes via self-enhancement gratifications. Additionally, exposure to nationalistic rhetoric also indirectly influences uncritical patriotism via social uncertainty reduction gratifications. Our study demonstrates the utility of a mixed-method approach and points out directions for future research on the (re)construction of social identities through mediasport

Using Design of Experiments in Finite Element Modeling to Identify Critical Variables for Laser Powder Bed Fusion

Input of accurate material and simulation parameters is critical for accurate predictions in Laser Powder Bed Fusion (L-PBF) Finite Element Analysis (FEA). It is challenging and resource consuming to run experiments that measure and control all possible material properties and process parameters. In this research, we developed a 3-dimensional thermal L-PBF FEA model for a single track laser scan on one layer of metal powder above a solid metal substrate. We applied a design of experiments (DOE) approach which varies simulation parameters to identify critical variables in L-PBF. DOE is an exploratory tool for examining a large number of factors and alternative modeling approaches. It also determines which approaches can best predict L-PBF process performance.Mechanical Engineerin

Sequencing of Androgen-Deprivation Therapy of Short Duration With Radiotherapy for Nonmetastatic Prostate Cancer (SANDSTORM): A Pooled Analysis of 12 Randomized Trials

Càncer de pròstata; Teràpia de privació d'andrògensCáncer de próstata; Terapia de privación de andrógenosProstate cancer; Androgen-deprivation therapyPURPOSE The sequencing of androgen-deprivation therapy (ADT) with radiotherapy (RT) may affect outcomes for prostate cancer in an RT-field size-dependent manner. Herein, we investigate the impact of ADT sequencing for men receiving ADT with prostate-only RT (PORT) or whole-pelvis RT (WPRT). MATERIALS AND METHODS Individual patient data from 12 randomized trials that included patients receiving neoadjuvant/concurrent or concurrent/adjuvant short-term ADT (4-6 months) with RT for localized disease were obtained from the Meta-Analysis of Randomized trials in Cancer of the Prostate consortium. Inverse probability of treatment weighting (IPTW) was performed with propensity scores derived from age, initial prostate-specific antigen, Gleason score, T stage, RT dose, and mid-trial enrollment year. Metastasis-free survival (primary end point) and overall survival (OS) were assessed by IPTW-adjusted Cox regression models, analyzed independently for men receiving PORT versus WPRT. IPTW-adjusted Fine and Gray competing risk models were built to evaluate distant metastasis (DM) and prostate cancer–specific mortality. RESULTS Overall, 7,409 patients were included (6,325 neoadjuvant/concurrent and 1,084 concurrent/adjuvant) with a median follow-up of 10.2 years (interquartile range, 7.2-14.9 years). A significant interaction between ADT sequencing and RT field size was observed for all end points (P interaction < .02 for all) except OS. With PORT (n = 4,355), compared with neoadjuvant/concurrent ADT, concurrent/adjuvant ADT was associated with improved metastasis-free survival (10-year benefit 8.0%, hazard ratio [HR], 0.65; 95% CI, 0.54 to 0.79; P < .0001), DM (subdistribution HR, 0.52; 95% CI, 0.33 to 0.82; P = .0046), prostate cancer–specific mortality (subdistribution HR, 0.30; 95% CI, 0.16 to 0.54; P < .0001), and OS (HR, 0.69; 95% CI, 0.57 to 0.83; P = .0001). However, in patients receiving WPRT (n = 3,049), no significant difference in any end point was observed in regard to ADT sequencing except for worse DM (HR, 1.57; 95% CI, 1.20 to 2.05; P = .0009) with concurrent/adjuvant ADT. CONCLUSION ADT sequencing exhibits a significant impact on clinical outcomes with a significant interaction with field size. Concurrent/adjuvant ADT should be the standard of care where short-term ADT is indicated in combination with PORT.Funding support for this study comes from the Prostate Cancer Foundation and ASTRO to AUK. AUK also thanks generous donations from the DeSilva, McCarrick, and Bershad families. A.T. acknowledges support from Cancer Research UK (C33589/A28284 and C7224/A28724) the National Institute for Health Research (NIHR) Cancer Research Network. This project represents independent research supported by the National Institute for Health research (NIHR) Biomedical Research Centre at The Royal Marsden NHS Foundation Trust and the Institute of Cancer Research, London. N.G.Z. is supported by the American Cancer Society – Tri State CEOs Against Cancer Clinician Scientist Development Grant, CSDG‐20‐013‐01‐CCE (2020)