13 research outputs found

    Prevalence of molar-incisor hypomineralization in Milwaukee, Wisconsin, USA: a pilot study

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    Megan Davenport,1 Andrew D Welles,2 Matina V Angelopoulou,2 Cesar Gonzalez,3 Christopher Okunseri,4 Lori Barbeau,1 Naveen K Bansal,5 Rodney J Vergotine,6 Brian D Hodgson71Pediatric Dentistry Residency Program, Children’s Hospital of Wisconsin, Milwaukee, WI 53201, USA; 2Marquette University School of Dentistry, Milwaukee, WI 53233, USA; 3Predoctoral Program in Pediatric Dentistry, Marquette University School of Dentistry, Milwaukee, WI 53233, USA; 4Predoctoral Program in Dental Public Health, Marquette University School of Dentistry, Milwaukee, WI 53233, USA; 5Department of Mathematics, Statistics, and Computer Science, Marquette University, Milwaukee, WI, USA; 6College of Dental Medicine – Illinois [CDMI], Midwestern University, Downers Grove, IL, USA; 7Pediatric Dentistry Residency Program, Children’s Hospital of Wisconsin, Marquette University School of Dentistry, Milwaukee, WI, USAPurpose: This pilot study investigated the prevalence of Molar-Incisor Hypomineralization (MIH) in third-grade school children in Milwaukee Wisconsin, USA.Methods: A convenience sample of third-grade school children in the Milwaukee Public School System (MPS) participated in the study. Calibrated examiners trained on the European Academy of Paediatric Dentistry (EAPD) MIH recommendations examined the children between December 1, 2014 and June 30, 2015. Children were examined at their schools using a flashlight and mirror after receiving consent from parents/caregivers and assent from each child. Findings were recorded onto a standardized form by one of five trained examiners. Summary statistics were calculated, and bivariate analysis were done to identify factors associated with MIH.Results: A total of 375 children (average age =8.66 years, range 7–12) were examined, 60% females and 41% Hispanics. Overall, 36 (9.6%) of the children demonstrated findings consistent with the diagnosis of MIH. Among the teeth with MIH defects, severe defects were higher in lower molars. There were no statistically significant differences between those with and without MIH by sex, race/ethnicity, and socioeconomic status in this study.Conclusion: The study revealed that 9.6% of the children examined were affected by MIH. Future studies should focus on statewide and/or nationwide surveys in the United States to ascertain the extent and severity of the condition.Keywords: molar incisor hypomineralization, MIH, children, prevalence, United State

    Venezuelan Equine Encephalitis Replicon Immunization Overcomes Intrinsic Tolerance and Elicits Effective Anti-tumor Immunity to the ‘Self’ tumor-associated antigen, neu in a Rat Mammary Tumor Model

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