Effects of Tridocosahexaenoyl-Glycerol Emulsion on Proteinuria in Rats with Nephrotoxic Serum Nephritis

Background: Docosahexaenoic acid (DHA) is one of the n–3 polyunsaturated fatty acids and an important component of cell membrane phospholipids (PL). Nephrotoxic serum (NTS) nephritis was a worldwide model of the Goodpasture syndrome. We investigated the effects of tridocosahexaenoyl-glycerol (DHA-TG) emulsion on proteinuria in rats with NTS nephritis. Methods: Sixteen male Wistar rats weighing approximately 200 g were used. Twelve rats were treated with NTS via the tail vein and divided into 3 groups (groups A, B, and C). Another 4 rats treated with saline served as controls (group D). DHA-TG and soybean oil emulsions were intraperitoneally administered to the rats in groups A and B, respectively, 24 h prior to NTS injection, and 0, 1, 2, 3, 4, and 5 days after the injection. Saline was administered to the rats in groups C and D in the same manner. All rats were sacrificed on day 6 to obtain plasma and kidney samples. Analyses of urinary protein levels and fatty acid composition of plasma and kidney as well as histological examination of the kidneys were performed. Results: Urinary protein levels in group A were significantly lower than those in group C (35.0 ± 13.3 vs. 79.2 ± 11.8 mg/day on day 5, means ± SE, p Conclusions: These results suggest that the DHA-TG emulsion may have beneficial effects on NTS nephritis in the rat

Paroxysmal nocturnal hemoglobinuria in systemic lupus erythematosus: a case report

<p>Abstract</p> <p>Introduction</p> <p>Paroxysmal nocturnal hemoglobinuria is an acquired disorder of hemopoiesis and is characterized by recurrent episodes of intravascular hemolysis due to an increased sensitivity to complement-mediated hemolysis. Systemic lupus erythematosus with paroxysmal nocturnal hemoglobinuria is very rare. We report a case of paroxysmal nocturnal hemoglobinuria that developed in a patient with systemic lupus erythematosus and lupus nephritis.</p> <p>Case presentation</p> <p>A 29-year-old Mongolian woman had systemic lupus erythematosus, which manifested only as skin lesions when she was 12 years old. She had leg edema and proteinuria when she was 23 years old, and a renal biopsy revealed lupus nephritis (World Health Organization type IV). She had been treated with steroids and immunosuppressant therapy. At 29, she had headaches, nausea, general fatigue, and severe pancytopenia and was admitted to our hospital. A laboratory evaluation showed hemolytic anemia. Further examination showed a neutrophil alkaline phosphatase score of 46 points, a CD55 value of 18%, and a CD59 value of 78.6%. The results of Ham test and sugar water tests were positive. The constellation of symptoms throughout the clinical course and the laboratory findings suggested paroxysmal nocturnal hemoglobinuria.</p> <p>Conclusions</p> <p>To the best of our knowledge, systemic lupus erythematosus with paroxysmal nocturnal hemoglobinuria is very rare. Clinicians should be aware of the association between autoimmune and hematological diseases.</p

Electroweak Symmetry Breaking via UV Insensitive Anomaly Mediation

Anomaly mediation solves the supersymmetric flavor and CP problems. This is because the superconformal anomaly dictates that supersymmetry breaking is transmitted through nearly flavor-blind infrared physics that is highly predictive and UV insensitive. Slepton mass squareds, however, are predicted to be negative. This can be solved by adding D-terms for U(1)_Y and U(1)_{B-L} while retaining the UV insensitivity. In this paper we consider electroweak symmetry breaking via UV insensitive anomaly mediation in several models. For the MSSM we find a stable vacuum when tanbeta < 1, but in this region the top Yukawa coupling blows up only slightly above the supersymmetry breaking scale. For the NMSSM, we find a stable electroweak breaking vacuum but with a chargino that is too light. Replacing the cubic singlet term in the NMSSM superpotential with a term linear in the singlet we find a stable vacuum and viable spectrum. Most of the parameter region with correct vacua requires a large superpotential coupling, precisely what is expected in the ``Fat Higgs'' model in which the superpotential is generated dynamically. We have therefore found the first viable UV complete, UV insensitive supersymmetry breaking model that solves the flavor and CP problems automatically: the Fat Higgs model with UV insensitive anomaly mediation. Moreover, the cosmological gravitino problem is naturally solved, opening up the possibility of realistic thermal leptogenesis.Comment: 27 pages, 3 figures, 1 tabl