58 research outputs found
A randomised controlled trial of Caphosol mouthwash in management of radiation-induced mucositis in head and neck cancer.
Purpose This phase III, non-blinded, parallel-group, randomised controlled study evaluated the efficacy of Caphosol mouthwash in the management of radiation-induced oral mucositis (OM) in patients with head and neck cancer (HNC) undergoing radical (chemo)radiotherapy.Patients and methods Eligible patients were randomised at 1:1 to Caphosol plus standard oral care (intervention) or standard oral care alone (control), stratified by radiotherapy technique and use of concomitant chemotherapy. Patients in the intervention arm used Caphosol for 7weeks: 6weeks during and 1-week post-radiotherapy. The primary endpoint was the incidence of severe OM (CTCAE ⩾grade 3) during and up to week 8 post-radiotherapy. Secondary endpoints include pharyngeal mucositis, dysphagia, pain and quality of life.Results The intervention (n=108) and control (n=107) arms were well balanced in terms of patient demographics and treatment characteristics. Following exclusion of patients with missing data, 210 patients were available for analysis. The incidence of severe OM did not differ between the intervention and control arms (64.1% versus 65.4%, p=0.839). Similarly, no significant benefit was observed for other secondary endpoints. Overall, compliance with the recommended frequency of Caphosol was low.Conclusion Caphosol did not reduce the incidence or duration of severe OM during and after radiotherapy in HNC
Potencial agronômico de híbridos de minitomate com hábito de crescimento determinado e indeterminado
Conceptual and methodological aspects in clinical and epidemiologic studies: Contributions to the scientific Field of Food and Nutrition in Brazil
Heterocedasticidade entre fileiras e colheitas de caracteres produtivos de tomate cereja e estimativa do tamanho de parcela
Obesidade geral e abdominal em idosos do Sul do Brasil: resultados do estudo COMO VAI?
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