45 research outputs found
Knowledge on dental trauma and orthodontic tooth movement held by a group of orthodontists
Full text linkClinical attributes, treatment, and control in hypertension (CATCH)—a French and Italian longitudinal patient database study
Get PDFDrug - related emergency department visits by elderly patients presenting with non-specific complaints
Get PDFDrug metabolism and ageing
No full textImportant changes in drug metabolism occur with ageing. Age-associated reductions in function of some but not all cytochrome P450 enzymes (CYPs) have been described. Induction and inhibition of CYPs needs to be revisited in light of recent advances. The function and pharmacology of transporters have not yet been examined for an age-related effect. Finally, the concept of frailty is being underpinned by studies documenting a decline in drug metabolism and changes in disposition in frail older people compared with either healthy elderly or the young
Pharmacokinetics of ruboxistaurin are significantly altered by rifampicin-mediated CYP3A4 induction
No full text10.1111/j.1365-2125.2005.02540.xBritish Journal of Clinical Pharmacology612200-210BCPH
Microscopic evaluation of induced tooth movement after subluxation trauma: an experimental study in rats
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Poor correlation between 6β-hydroxycortisol:cortisol molar ratios and midazolam clearance as measure of hepatic CYP3A activity
Get PDFA non-invasive proposed method for measuring CYP3A activity is the urinary 6β-hydroxycortisol:cortisol ratio. This ratio has been used as an indicator of CYP3A induction and inhibition, with mixed results. This investigation evaluated the relationship between a validated, biomarker, intravenous midazolam clearance and the urinary cortisol ratio under constitutive conditions and with the influence of a moderate CYP3A inhibitor
Lack of In Vivo Correlation Between Indinavir and Saquinavir Exposure and Cytochrome P450 3A Phenotype as Assessed with Oral Midazolam as a Phenotype Probe
No full textSupernumerary Teeth in Premolar and Molar Regions and their Effect on Overall Restorative Treatment Plan
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