24 research outputs found
Primary endemic Cryptococcosis gattii by molecular type VGII in the state of Pará, Brazil
In vitro susceptibility characteristics of Cryptococcus neoformans varieties from AIDS patients in Goiânia, Brazil
Cryptococcosis in Atlántico, Colombia: an approximation of the prevalence of this mycosis and the distribution of the etiological agent in the environment
Ocorrência de Cryptococcus neoformans em excretas de pombos na cidade de Pelotas, Estado do Rio Grande do Sul
Isolation of Cryptococcus neoformans from hollows of living trees in the city of Alfenas, MG, Brazil
Decayed wood of <emph type="2">Syzygium cumini</emph> and <emph type="2">Ficus religiosa</emph> living trees in Delhi/New Delhi metropolitan area as natural habitat of <emph type="2">Cryptococcus neoformans</emph>
Cryptococcal meningitis in two apparently immunocompetent Maltese patients. Fallbericht. Cryptococcus-Meningitis bei zwei immunokompetenten maltesischen Patienten
Detection of Cryptococcus neoformans var. grubii in honeybee (Apis mellifera) colonies. Nachweis von Cryptococcus neoformans var. grubii in Stocken der Honigbiene (Apis mellifera)
Disseminated cryptococcosis initially presenting as cellulitis in a patient suffering from nephrotic syndrome
<p>Abstract</p> <p>Background</p> <p>Cryptococcosis is considered as an opportunistic infection because it mainly occurs in immunosuppressed hosts. C. neoformans is usually acquired by the respiratory route and then may disseminate hematogenously to other places, such as meninges, bone and skin. Cutaneous involvement is a rare but important feature of disseminated cryptococcosis with a poor outcome if misdiagnosis. We reported the first case of patients with nephrotic syndrome suffering from disseminated cryptococcosis initially presented as cellulitis.</p> <p>Case presentation</p> <p>A 34-year-old man developed severe cellulitis on his both lower extremities without any preceding injury and allergies. The patient had been treated with systemic corticosteroids nearly one year for nephrotic syndrome. According to the outcome of blood culture, the wound area was interpreted as bacterial cellulitis at first. However, the antimicrobial treatment made no response and the skin biopsy revealed the presence of Cryptococcus neoformans, which was subsequently confirmed by microbiological culture. Though the initiation of therapy with fluconazole 400 mg per day was immediately adopted, the patient’s conditions suddenly plummeted and he died in the end.</p> <p>Conclusion</p> <p>Since the poor outcome of disseminated cryptococcosis if unrecognized and untreated in time, it should be investigated rigorously as a differential diagnosis in patients with nephrotic syndrome suffering from cutaneous diseases.</p