Dual-wavelength ultra-short pulse generation by use of semiconductor laser diode

2002-2003 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

Subsideband generation and modulational instability lasing in a fiber soliton laser

2001-2002 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

Promoter DNA Methylation of Oncostatin M receptor-β as a Novel Diagnostic and Therapeutic Marker in Colon Cancer

In addition to genetic changes, the occurrence of epigenetic alterations is associated with accumulation of both genetic and epigenetic events that promote the development and progression of human cancer. Previously, we reported a set of candidate genes that comprise part of the emerging “cancer methylome”. In the present study, we first tested 23 candidate genes for promoter methylation in a small number of primary colon tumor tissues and controls. Based on these results, we then examined the methylation frequency of Oncostatin M receptor-β (OSMR) in a larger number of tissue and stool DNA samples collected from colon cancer patients and controls. We found that OSMR was frequently methylated in primary colon cancer tissues (80%, 80/100), but not in normal tissues (4%, 4/100). Methylation of OSMR was also detected in stool DNA from colorectal cancer patients (38%, 26/69) (cut-off in TaqMan-MSP, 4). Detection of other methylated markers in stool DNA improved sensitivity with little effect on specificity. Promoter methylation mediated silencing of OSMR in cell lines, and CRC cells with low OSMR expression were resistant to growth inhibition by Oncostatin M. Our data provide a biologic rationale for silencing of OSMR in colon cancer progression and highlight a new therapeutic target in this disease. Moreover, detection and quantification of OSMR promoter methylation in fecal DNA is a highly specific diagnostic biomarker for CRC

<title>TDM of FBG sensors by use of a tunable laser source</title>

The results of an investigation of the performance of a TDM FBG sensor array using a tunable laser source are reported. The system performance is found to be limited by the extinction ratio of the optical pulse modulator used for pulse amplitude modulation. Formulas that relate the crosstalk to the extinction ratio of the optical pulse modulator, the modulation parameters of the tunable laser, and the optical path differences among sensing channels are derived. Computer simulation shows that an array of 20 FBG sensors with 3 (mu) (epsilon) resolution can be realized with a commercially available single Mach-Zehnder type optical pulse modulator of -35 dB extinction ratio. Experiments with a 4-FBG sensor array demonstrated a strain resolution of about 3.98 (mu) (epsilon) with an optical pulse modulator of about -24 dB extinction ratio.Department of Electrical Engineerin

All-optical packet switching with all-optical header processing and 2R regeneration

2005 Conference on Lasers and Electro-Optics, CLEO, Baltimore, MD, 22-27 May 2005We demonstrate a 1×4 10 Gb/s all-optical packet switch with all-optical header processing and 2R regeneration using injection-locked Fabry-Perot lasers diodes. The header and payload rates are 5 Gb/s and 10 Gb/s respectively.Department of Electrical EngineeringDepartment of Electronic and Information EngineeringRefereed conference pape

Design of single-polarization PCF at 1300- and 1550-nm bands

Second European Workshop on Optical Fibre Sensors, Santander Spain, 9-11 Jun 2004The cut-off wavelengths of the two linearly polarized states in PCF can be designed by varying the diameters and pitch of the holes. Simulations show that single polarization operation over a range of up to 100 nm can be realized around 1.3 μm and 1.55 μm bands.Department of Electrical EngineeringRefereed conference pape

Photonic Crystal Fiber Based 10 GHz Optical Clock Recovery Using an Optical Parametric Oscillator

Conference on Lasers and Electro-Optics, 2007, CLEO 2007, Baltimore, MD, 6-11 May 2007We demonstrate a 10GHz optical clock recovery scheme based on optical parametric oscillator using highly nonlinear photonic crystal fiber as the dynamic gain medium.Department of Electrical EngineeringDepartment of Electronic and Information EngineeringRefereed conference pape

Annealing effects on the loss and birefringence of silicon oxynitride rectangular optical waveguides

Silicon oxynitride rectangular optical waveguides have been fabricated by plasma-enhanced chemical vapor deposition and dry etching. The propagation loss and polarization dependent loss in as-grown samples show a substantial reduction after the samples have been annealed. Birefringence measurements before and after annealing on waveguides of different widths suggest that the waveguide modal birefringence is strongly affected by both waveguide geometry and stress in the material. Hence, the modal birefringence can be minimized by designing the appropriate waveguide geometry to compensate for any stress effects. (c) 2005 American Institute of Physics

An all-optical packet-switched ring network

2005 Conference on Lasers and Electro-Optics, CLEO, Baltimore, MD, 22-27 May 2005We demonstrated an all-optical packet add-drop node for a uni-directional all-optical packet-switched ring network. All-optical add, drop, and clearance of packets are performed based on all-optical processing of packet headers. The header and payload rates are 5 Gb/s and 10 Gb/s respectively.Department of Electrical EngineeringDepartment of Electronic and Information EngineeringRefereed conference pape